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BIOMARKER:
EGFR overexpression
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
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EGFR overexpression
Esophageal Squamous Cell Carcinoma
EGFR overexpression
Esophageal Squamous Cell Carcinoma
erlotinib
Sensitive: B - Late Trials
erlotinib
Sensitive
:
B
erlotinib
Sensitive: B - Late Trials
erlotinib
Sensitive
:
B
EGFR overexpression
Non Small Cell Lung Cancer
EGFR overexpression
Non Small Cell Lung Cancer
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
EGFR overexpression
Non Small Cell Lung Cancer
EGFR overexpression
Non Small Cell Lung Cancer
necitumumab
Sensitive: C2 – Inclusion Criteria
necitumumab
Sensitive
:
C2
necitumumab
Sensitive: C2 – Inclusion Criteria
necitumumab
Sensitive
:
C2
EGFR overexpression
Squamous Cell Carcinoma of Head and Neck
EGFR overexpression
Squamous Cell Carcinoma of Head and Neck
cetuximab
Sensitive: C2 – Inclusion Criteria
cetuximab
Sensitive
:
C2
cetuximab
Sensitive: C2 – Inclusion Criteria
cetuximab
Sensitive
:
C2
EGFR overexpression
Esophageal Squamous Cell Carcinoma
EGFR overexpression
Esophageal Squamous Cell Carcinoma
Z650
Sensitive: C2 – Inclusion Criteria
Z650
Sensitive
:
C2
Z650
Sensitive: C2 – Inclusion Criteria
Z650
Sensitive
:
C2
EGFR overexpression
Glioblastoma
EGFR overexpression
Glioblastoma
ABBV-321
Sensitive: C2 – Inclusion Criteria
ABBV-321
Sensitive
:
C2
ABBV-321
Sensitive: C2 – Inclusion Criteria
ABBV-321
Sensitive
:
C2
EGFR overexpression
Gastric Cancer
EGFR overexpression
Gastric Cancer
ASLAN001
Sensitive: C3 – Early Trials
ASLAN001
Sensitive
:
C3
ASLAN001
Sensitive: C3 – Early Trials
ASLAN001
Sensitive
:
C3
EGFR overexpression
Colorectal Cancer
EGFR overexpression
Colorectal Cancer
cetuximab
Sensitive: C3 – Early Trials
cetuximab
Sensitive
:
C3
cetuximab
Sensitive: C3 – Early Trials
cetuximab
Sensitive
:
C3
EGFR overexpression
Gastric Cancer
EGFR overexpression
Gastric Cancer
GC-1118A
Sensitive: C3 – Early Trials
GC-1118A
Sensitive
:
C3
GC-1118A
Sensitive: C3 – Early Trials
GC-1118A
Sensitive
:
C3
EGFR overexpression
Lung Adenocarcinoma
EGFR overexpression
Lung Adenocarcinoma
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
EGFR overexpression
Colorectal Cancer
EGFR overexpression
Colorectal Cancer
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR overexpression
Hepatocellular Cancer
EGFR overexpression
Hepatocellular Cancer
gefitinib + lenvatinib
Sensitive: C3 – Early Trials
gefitinib + lenvatinib
Sensitive
:
C3
gefitinib + lenvatinib
Sensitive: C3 – Early Trials
gefitinib + lenvatinib
Sensitive
:
C3
EGFR overexpression
Non Small Cell Lung Cancer
EGFR overexpression
Non Small Cell Lung Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
EGFR overexpression
Thyroid Gland Papillary Carcinoma
EGFR overexpression
Thyroid Gland Papillary Carcinoma
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
EGFR overexpression
Osteosarcoma
EGFR overexpression
Osteosarcoma
gemcitabine
Resistant: D – Preclinical
gemcitabine
Resistant
:
D
gemcitabine
Resistant: D – Preclinical
gemcitabine
Resistant
:
D
EGFR overexpression
Triple Negative Breast Cancer
EGFR overexpression
Triple Negative Breast Cancer
ABT 263 + ABBV-321
Sensitive: D – Preclinical
ABT 263 + ABBV-321
Sensitive
:
D
ABT 263 + ABBV-321
Sensitive: D – Preclinical
ABT 263 + ABBV-321
Sensitive
:
D
EGFR overexpression
Triple Negative Breast Cancer
EGFR overexpression
Triple Negative Breast Cancer
ABT 263 + ABT-414
Sensitive: D – Preclinical
ABT 263 + ABT-414
Sensitive
:
D
ABT 263 + ABT-414
Sensitive: D – Preclinical
ABT 263 + ABT-414
Sensitive
:
D
EGFR overexpression
Glioblastoma
EGFR overexpression
Glioblastoma
ONC201
Resistant: D – Preclinical
ONC201
Resistant
:
D
ONC201
Resistant: D – Preclinical
ONC201
Resistant
:
D
EGFR overexpression
Lung Cancer
EGFR overexpression
Lung Cancer
cetuximab + avelumab
Sensitive: D – Preclinical
cetuximab + avelumab
Sensitive
:
D
cetuximab + avelumab
Sensitive: D – Preclinical
cetuximab + avelumab
Sensitive
:
D
EGFR overexpression
Gastric Cancer
EGFR overexpression
Gastric Cancer
cetuximab
Sensitive: D – Preclinical
cetuximab
Sensitive
:
D
cetuximab
Sensitive: D – Preclinical
cetuximab
Sensitive
:
D
EGFR overexpression
Non Small Cell Lung Cancer
EGFR overexpression
Non Small Cell Lung Cancer
cetuximab
Sensitive: D – Preclinical
cetuximab
Sensitive
:
D
cetuximab
Sensitive: D – Preclinical
cetuximab
Sensitive
:
D
EGFR overexpression
Breast Cancer
EGFR overexpression
Breast Cancer
vandetanib
Sensitive: D – Preclinical
vandetanib
Sensitive
:
D
vandetanib
Sensitive: D – Preclinical
vandetanib
Sensitive
:
D
EGFR overexpression
Esophageal Squamous Cell Carcinoma
EGFR overexpression
Esophageal Squamous Cell Carcinoma
nimotuzumab
Sensitive: D – Preclinical
nimotuzumab
Sensitive
:
D
nimotuzumab
Sensitive: D – Preclinical
nimotuzumab
Sensitive
:
D
EGFR overexpression
Glioblastoma
EGFR overexpression
Glioblastoma
afatinib + enzalutamide
Sensitive: D – Preclinical
afatinib + enzalutamide
Sensitive
:
D
afatinib + enzalutamide
Sensitive: D – Preclinical
afatinib + enzalutamide
Sensitive
:
D
EGFR overexpression
Estrogen Receptor Positive Breast Cancer
EGFR overexpression
Estrogen Receptor Positive Breast Cancer
palbociclib
Resistant: D – Preclinical
palbociclib
Resistant
:
D
palbociclib
Resistant: D – Preclinical
palbociclib
Resistant
:
D
EGFR overexpression
Solid Tumor
EGFR overexpression
Solid Tumor
BB-1705
Sensitive: D – Preclinical
BB-1705
Sensitive
:
D
BB-1705
Sensitive: D – Preclinical
BB-1705
Sensitive
:
D
EGFR overexpression
Triple Negative Breast Cancer
EGFR overexpression
Triple Negative Breast Cancer
LR004-VC-MMAE
Sensitive: D – Preclinical
LR004-VC-MMAE
Sensitive
:
D
LR004-VC-MMAE
Sensitive: D – Preclinical
LR004-VC-MMAE
Sensitive
:
D
EGFR overexpression
Breast Cancer
EGFR overexpression
Breast Cancer
LR004-VC-MMAE
Sensitive: D – Preclinical
LR004-VC-MMAE
Sensitive
:
D
LR004-VC-MMAE
Sensitive: D – Preclinical
LR004-VC-MMAE
Sensitive
:
D
EGFR overexpression
Non Small Cell Lung Cancer
EGFR overexpression
Non Small Cell Lung Cancer
LR004-VC-MMAE
Sensitive: D – Preclinical
LR004-VC-MMAE
Sensitive
:
D
LR004-VC-MMAE
Sensitive: D – Preclinical
LR004-VC-MMAE
Sensitive
:
D
EGFR overexpression
Esophageal Squamous Cell Carcinoma
EGFR overexpression
Esophageal Squamous Cell Carcinoma
LR004-VC-MMAE
Sensitive: D – Preclinical
LR004-VC-MMAE
Sensitive
:
D
LR004-VC-MMAE
Sensitive: D – Preclinical
LR004-VC-MMAE
Sensitive
:
D
EGFR overexpression
Pancreatic Cancer
EGFR overexpression
Pancreatic Cancer
HTI-1511
Sensitive: D – Preclinical
HTI-1511
Sensitive
:
D
HTI-1511
Sensitive: D – Preclinical
HTI-1511
Sensitive
:
D
EGFR overexpression
Non Small Cell Lung Cancer
EGFR overexpression
Non Small Cell Lung Cancer
HTI-1511
Sensitive: D – Preclinical
HTI-1511
Sensitive
:
D
HTI-1511
Sensitive: D – Preclinical
HTI-1511
Sensitive
:
D
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