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BIOMARKER:

EGFRVIII expression + PTEN expression

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Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor, PTEN, Phosphatase and tensin homolog, Mutated In Multiple Advanced Cancers 1, Phosphatase And Tensin Homolog, Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, MMAC1, TEP1, MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 10, Mitochondrial Phosphatase And Tensin Protein Alpha, Phosphatase And Tensin-Like Protein, Protein Tyrosine Phosphatase, Mitochondrial PTENalpha, PTENbeta, PTEN1
Entrez ID:
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Trials
EGFRVIII expression + PTEN expression
GBM
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFRVIII expression + PTEN expression
Glioma
erlotinib
Sensitive: C3 – Early Trials
EGFRVIII expression + PTEN expression
GBM
erlotinib
Resistant: C3 – Early Trials