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BIOMARKER:
EGFR mutation + KRAS mutation
i
Other names:
KRAS, KRAS1, KRAS2, Kirsten rat sarcoma viral oncogene homolog, EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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Entrez ID:
1956
;
3845
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
KRAS mutation (239)
EGFR mutation (196)
KRAS G12C (159)
EGFR L858R (90)
EGFR T790M (64)
KRAS G12D (64)
EGFR exon 20 insertion (50)
EGFR wild-type (41)
KRAS G12V (36)
KRAS wild-type (26)
EGFR L861Q (23)
EGFR C797S (22)
KRAS G13D (22)
EGFR exon 21 mutation (20)
KRAS G12R (18)
RAS wild-type (17)
EGFR L858R + EGFR T790M (16)
EGFR exon 19 mutation (14)
KRAS G12A (14)
EGFR A763_Y764insFQEA (13)
EGFR G719X (13)
EGFR S768I (12)
EGFR mutation + TP53 mutation (11)
KRAS G12 (10)
EGFR C797S + EGFR T790M + EGFR L858R (9)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion (9)
KRAS G12S (9)
EGFR E746_A750del (8)
EGFR exon 20 mutation (8)
EGFRvIII mutation (8)
KRAS G13 (8)
KRAS mutation + STK11 mutation (8)
EGFR G719A (7)
EGFR G719S (7)
EGFR L747P (7)
EGFR exon 18 mutation (7)
EGFR wild-type + ALK wild-type (7)
KRAS Q61H (7)
KRAS exon 2 mutation (7)
EGFR T790M + EGFR C797S (6)
EGFR exon 19 deletion + EGFR L861Q (6)
EGFR mutation + BRAF V600E (6)
TP53 mutation + KRAS mutation (6)
EGFR G719X + EGFR S768I (5)
EGFR K745_E746insIPVAIK (5)
KRAS G12C + STK11 mutation (5)
EGFR G719C (4)
EGFR L861Q + EGFR G719X (4)
EGFR S492R (4)
EGFR mutation + PIK3CA mutation (4)
KRAS A146 (4)
KRAS A59T (4)
KRAS Q61 (4)
EGFR D770 delinsGY (3)
EGFR D770_N771insSVD (3)
EGFR E709K (3)
EGFR E709_T710delinsD (3)
EGFR E746_S752delinsV (3)
EGFR G724S (3)
EGFR H773_V774insH (3)
EGFR L718Q (3)
EGFR L833V + EGFR H835L (3)
EGFR L858R + EGFR M766Q (3)
EGFR R521K (3)
EGFR T790M negative (3)
EGFR T854A (3)
EGFR exon 18-25 duplication (3)
EGFR exon 19 deletion + EGFR C797S (3)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S (3)
EGFR mutation + CREBBP mutation (3)
HER-2 V777L + EGFR L858R (3)
KRAS A146T (3)
KRAS G12C + TP53 mutation (3)
KRAS G12D + STK11 mutation (3)
KRAS Y96D (3)
KRAS Y96S (3)
EGFR A767_V769dup (2)
EGFR D761Y (2)
EGFR D770_N771insGT (2)
EGFR E114K (2)
EGFR G465R (2)
EGFR G63R (2)
EGFR G719A + EGFR G779C (2)
EGFR G719C + EGFR S768I (2)
EGFR G719S + EGFR L861Q (2)
EGFR G874S (2)
EGFR H1975 (2)
EGFR K708R (2)
EGFR L747-S752 del (2)
EGFR L747_A750delinsP (2)
EGFR L833F + EGFR L861Q (2)
EGFR L858R + EGFR A871G (2)
EGFR L858R + EGFR L718Q (2)
EGFR L858R + RBM10 Y36* (2)
EGFR L858R + TP53 mutation (2)
EGFR L860R (2)
EGFR L861R (2)
EGFR N771delinsKG (2)
EGFR P596L (2)
EGFR R165Q (2)
EGFR R222C (2)
EGFR S645C + EGFR L858R (2)
EGFR T790M + KRAS mutation (2)
EGFR T790M + PIK3CA H1047R (2)
EGFR V802I + KRAS mutation (2)
EGFR exon 19 duplication (2)
EGFR exon 19 insertion (2)
EGFR exon 20 insertion + EGFR T790M (2)
EGFR mutation + ATM mutation (2)
EGFR mutation + BRAF V600 (2)
EGFR mutation + CDKN2A mutation (2)
EGFR mutation + EGFR T790M (2)
EGFR mutation + MET mutation (2)
EGFR mutation + NRAS Q61K (2)
EGFR mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + ARID1A mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
EGFR mutation + TP53 mutation + NF1 mutation (2)
EGFR mutation + TP53 mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + RB1 mutation (2)
EGFR T790L (2)
EGFR delE709_T710insD (2)
KRAS mutation + EGFR wild-type (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
KEAP1 mutation + KRAS mutation (2)
KRAS A146V (2)
KRAS A59 (2)
KRAS A59S (2)
KRAS G12C + KEAP1 mutation (2)
KRAS G12D + KRAS G12V (2)
KRAS G13A (2)
KRAS G13C (2)
KRAS G13D + BRAF mutation (2)
KRAS K117 (2)
KRAS Q99L (2)
KRAS R68M (2)
KRAS exon 12 mutation (2)
KRAS exon 2 wild-type (2)
KRAS exon 3 mutation (2)
KRAS exon 4 mutation (2)
KRAS mutation + STK11 mutation + KEAP1 mutation (2)
KRAS mutation + TP53 wild-type (2)
PIK3CA mutation + KRAS mutation (2)
STK11 mutation + KEAP1 mutation + KRAS G12C (2)
ALK L1152R + EGFR mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
BRAF mutation + EGFR mutation (1)
CDK4 mutation + EGFR mutation (1)
DDR + EGFR mutation (1)
EGFR 181946 C>T (1)
EGFR A289V (1)
EGFR A750P (1)
EGFR A763V (1)
EGFR A767_V769dupASV (1)
EGFR A767dupASV (1)
EGFR A859T (1)
EGFR C796S (1)
EGFR C796S + EGFR V802I (1)
EGFR C797S + EGFR C796S (1)
EGFR C797S + EGFR exon 20 insertion (1)
EGFR D770_N771insGL (1)
EGFR D770_N771insGT + EGFR V774_C775insHV (1)
EGFR E690K (1)
EGFR E709A + EGFR G719C (1)
EGFR E709G (1)
EGFR E709Q (1)
EGFR E746 (1)
EGFR E746G (1)
EGFR E746_T751delinsl (1)
EGFR E758D (1)
EGFR E884K (1)
EGFR G2607A (1)
EGFR G709T (1)
EGFR G719A + EGFR I706T (1)
EGFR G719A + EGFR L833V (1)
EGFR G719A + EGFR R776C (1)
EGFR G719A + EGFR S768I (1)
EGFR G719A + EGFR T790M (1)
EGFR G719C + EGFR E709V (1)
EGFR G719D (1)
EGFR G719S + EGFR S768I (1)
EGFR G719X + EGFR E709F (1)
EGFR G719X + EGFR L861Q + EGFR S768I (1)
EGFR G719X + TP53 mutation (1)
EGFR G724S + EGFR R776H (1)
EGFR G735R (1)
EGFR G796S (1)
EGFR G836S (1)
EGFR H773L + EGFR V774M (1)
EGFR H773_V774insNPH (1)
EGFR H773delinsNPY (1)
EGFR H773delinsYNPY (1)
EGFR H835L (1)
EGFR I744_K745insKIPVAI (1)
EGFR K467T (1)
EGFR K757R (1)
EGFR L718V + TP53 V727M + EGFR L858R (1)
EGFR L746_T70delinsS (1)
EGFR L746_T750del (1)
EGFR L747S (1)
EGFR L747_A750>P (1)
EGFR L747_P753delinsS (1)
EGFR L747_T751delinsP (1)
EGFR L747_T751delinsS (1)
EGFR L747_T753delinsS (1)
EGFR L833V (1)
EGFR L8585R + EGFR T790M + RBM10 G840fs*7 (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR L858R + EGFR C797S (1)
EGFR L858R + EGFR D761Y (1)
EGFR L858R + EGFR E709G (1)
EGFR L858R + EGFR E709X (1)
EGFR L858R + EGFR E709X + CTNNB1 mutation (1)
EGFR L858R + EGFR E884K (1)
EGFR L858R + EGFR L747V (1)
EGFR L858R + EGFR R776H (1)
EGFR L858R + EGFR S765I (1)
EGFR L858R + EGFR S768I (1)
EGFR L858R + EGFR T854A (1)
EGFR L858R + EGFR V843I (1)
EGFR L858R + EGFR exon 21 deletion (1)
EGFR L858R + FGF3 mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR L858R + RBM10 2167-1 G>T (1)
EGFR L858R + RBM10 Q255* (1)
EGFR L858R + RBM10 Q595* (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR L858R + TP53 wild-type (1)
EGFR L861P (1)
EGFR L861Q + EGFR exon 20 insertion (1)
EGFR L861Q + TP53 mutation (1)
EGFR L861Q + TP53 mutation + RB1 mutation (1)
EGFR L861X (1)
EGFR M277E (1)
EGFR M766Q (1)
EGFR M766_A767insASV (1)
EGFR N771_P772insH (1)
EGFR N771_P772insVal (1)
EGFR P546S (1)
EGFR P753S (1)
EGFR P772_H773insYNP (1)
EGFR P772_H773insYNP + EGFR H773Y (1)
EGFR P772_V774insPHV (1)
EGFR Q787Q (1)
EGFR R1052K (1)
EGFR R451C (1)
EGFR R776C + EGFR L861Q (1)
EGFR R776H (1)
EGFR R776H + EGFR C797S (1)
EGFR R776H + EGFR L861Q (1)
EGFR S464L (1)
EGFR S720I (1)
EGFR S752_I759del (1)
EGFR S768I + TP53 mutation (1)
EGFR S768_D770dup (1)
EGFR S768_D770dupSVD (1)
EGFR S768dupSVD (1)
EGFR S784F (1)
EGFR T263P (1)
EGFR T751_I759>S (1)
EGFR T790I (1)
EGFR T790M + BRAF V600E (1)
EGFR T790M + EGFR L792F (1)
EGFR T790M + EGFR L833V + EGFR H835L (1)
EGFR T790M + EGFR L861Q (1)
EGFR T790M + EGFR S768I + EGFR L858R (1)
EGFR T790M + HER-2 mutation (1)
EGFR T790M + KRAS G12V (1)
EGFR T790M + MET mutation (1)
EGFR T790M + PARP1 mutation (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR T790M + TP53 R237C (1)
EGFR T854A + EGFR T790M (1)
EGFR T858R (1)
EGFR V769A (1)
EGFR V769_770insASV (1)
EGFR V774_C775insHV (1)
EGFR V786M (1)
EGFR V802I (1)
EGFR V834L (1)
EGFR Y764_V765insHH (1)
EGFR exon 18 mutation + EGFR exon 21 mutation (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR exon 19 deletion + BRCA2 mutation (1)
EGFR exon 19 deletion + EGFR G724S + EGFR T790M (1)
EGFR exon 19 deletion + EGFR T790L (1)
EGFR exon 19 deletion + TP53 exon 8 mutation (1)
EGFR exon 19 deletion + TP53 mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
EGFR exon 20 insertion + EGFR G719X + EGFR L858R (1)
EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)
EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)
EGFR exon 20 mutation + EGFR V774M + EGFR S768I (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR exon 21 mutation + EGFR L858R (1)
EGFR mutation + ALK mutation (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
EGFR mutation + CTBP2 rs376695472 (1)
EGFR mutation + CTBP2 rs945665113 (1)
EGFR mutation + EGFR T790M + EGFR C797S (1)
EGFR mutation + FAT3 mutation (1)
EGFR mutation + GRM8 mutation (1)
EGFR mutation + HLA-DRB5 rs1071748 (1)
EGFR mutation + HLA-DRB5 rs184278615 (1)
EGFR mutation + HLA-DRB5 rs20146916 (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation + KIR3DL1 rs199822561 (1)
EGFR mutation + KIR3DL1 rs200821495 (1)
EGFR mutation + KIR3DL1 rs72629105 (1)
EGFR mutation + KIR3DL2 rs973541788 (1)
EGFR mutation + LRP1B mutation (1)
EGFR mutation + MDM4 *32C>A (1)
EGFR mutation + MET Y1003N (1)
EGFR mutation + NOTCH1 mutation (1)
EGFR mutation + RB1 mutation (1)
EGFR mutation + SMAD4 mutation (1)
EGFR mutation + TP53 exon 6 mutation (1)
EGFR mutation + TP53 exon 7 mutation (1)
EGFR mutation + UBXN11 mutation (1)
EGFR mutation + ZNF217 mutation (1)
EGFR mutation+ IDH1 R132H (1)
EGFR rearrangement (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EGFR wild-type + MET wild-type (1)
EGFR-SEPTIN14 rearrangement (1)
EGFR G729A + EGFR L858R (1)
EGFR T790M + TP53 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH2 R140W + EGFR L858R (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
MTOR L1433S + EGFR L858R + EGFR T790M (1)
ALK rearrangement + KRAS mutation (1)
APC mutation + KRAS mutation (1)
ARID1A mutation+ KRAS G12C (1)
BRAF V600E + KRAS G12R (1)
DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)
KIR2DS4 mutation + KRAS mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12C + ATM wild-type (1)
KRAS G12C + KRAS G12V (1)
KRAS G12C + SMARCA4 wild-type (1)
KRAS G12D + DNMT3A C559fsX (1)
KRAS G12V + BRAF V600E (1)
KRAS G12V + STK11 mutation (1)
KRAS G12V + TP53 mutation + APC mutation (1)
KRAS G60D (1)
KRAS G61 (1)
KRAS G61H + KRAS G12A (1)
KRAS N116H (1)
KRAS N116T (1)
KRAS Q22X (1)
KRAS Q61K (1)
KRAS Q61L (1)
KRAS S89P (1)
KRAS V12 (1)
KRAS exon 13 mutation (1)
KRAS mutation + ATM mutation (1)
KRAS mutation + KEAP1 mutation (1)
KRAS mutation + SMARCA4 mutation (1)
KRAS mutation + STK11 deletion + KEAP1 deletion (1)
KRAS mutation + STK11 mutation + TP53 mutation (1)
KRAS mutation + U2AF1 mutation (1)
KRAS mutation + KMT2C mutation (1)
MAP2K1 G128D + KRAS mutation (1)
MET exon 14 mutation + KRAS G12A (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PTPN11 mutation + KRAS wild-type (1)
STK11 mutation + KEAP1 mutation + KRAS wild-type (1)
EGFR A839V (0)
EGFR E709A (0)
EGFR E709F (0)
EGFR G779C (0)
EGFR G873E (0)
EGFR H773L (0)
EGFR K754E (0)
EGFR L747_S752del (0)
EGFR L747_T750del (0)
EGFR L858R + EGFR G779S (0)
EGFR L858R + RBM10 Q255 (0)
EGFR R776C (0)
EGFR S765I (0)
EGFR T785A + EGFR L861Q + EGFR H297_E298 (0)
EGFR V774M (0)
EGFR mutation + APC mutation (0)
EGFR rs4947492 (0)
MET exon 14 skipping mutation + EGFR G709T (0)
BRAF V600E + KRAS G12D (0)
CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)
CDKN2A mutation + KRAS mutation (0)
KRAS A146P (0)
KRAS A59 (0)
KRAS G61H (0)
KRAS mutation + TP53 mutation (0)
KRAS mutation (239)
EGFR mutation (196)
KRAS G12C (159)
EGFR L858R (90)
EGFR T790M (64)
KRAS G12D (64)
EGFR exon 20 insertion (50)
EGFR wild-type (41)
KRAS G12V (36)
KRAS wild-type (26)
EGFR L861Q (23)
EGFR C797S (22)
KRAS G13D (22)
EGFR exon 21 mutation (20)
KRAS G12R (18)
RAS wild-type (17)
EGFR L858R + EGFR T790M (16)
EGFR exon 19 mutation (14)
KRAS G12A (14)
EGFR A763_Y764insFQEA (13)
EGFR G719X (13)
EGFR S768I (12)
EGFR mutation + TP53 mutation (11)
KRAS G12 (10)
EGFR C797S + EGFR T790M + EGFR L858R (9)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion (9)
KRAS G12S (9)
EGFR E746_A750del (8)
EGFR exon 20 mutation (8)
EGFRvIII mutation (8)
KRAS G13 (8)
KRAS mutation + STK11 mutation (8)
EGFR G719A (7)
EGFR G719S (7)
EGFR L747P (7)
EGFR exon 18 mutation (7)
EGFR wild-type + ALK wild-type (7)
KRAS Q61H (7)
KRAS exon 2 mutation (7)
EGFR T790M + EGFR C797S (6)
EGFR exon 19 deletion + EGFR L861Q (6)
EGFR mutation + BRAF V600E (6)
TP53 mutation + KRAS mutation (6)
EGFR G719X + EGFR S768I (5)
EGFR K745_E746insIPVAIK (5)
KRAS G12C + STK11 mutation (5)
EGFR G719C (4)
EGFR L861Q + EGFR G719X (4)
EGFR S492R (4)
EGFR mutation + PIK3CA mutation (4)
KRAS A146 (4)
KRAS A59T (4)
KRAS Q61 (4)
EGFR D770 delinsGY (3)
EGFR D770_N771insSVD (3)
EGFR E709K (3)
EGFR E709_T710delinsD (3)
EGFR E746_S752delinsV (3)
EGFR G724S (3)
EGFR H773_V774insH (3)
EGFR L718Q (3)
EGFR L833V + EGFR H835L (3)
EGFR L858R + EGFR M766Q (3)
EGFR R521K (3)
EGFR T790M negative (3)
EGFR T854A (3)
EGFR exon 18-25 duplication (3)
EGFR exon 19 deletion + EGFR C797S (3)
EGFR exon 19 deletion + EGFR T790M + EGFR C797S (3)
EGFR mutation + CREBBP mutation (3)
HER-2 V777L + EGFR L858R (3)
KRAS A146T (3)
KRAS G12C + TP53 mutation (3)
KRAS G12D + STK11 mutation (3)
KRAS Y96D (3)
KRAS Y96S (3)
EGFR A767_V769dup (2)
EGFR D761Y (2)
EGFR D770_N771insGT (2)
EGFR E114K (2)
EGFR G465R (2)
EGFR G63R (2)
EGFR G719A + EGFR G779C (2)
EGFR G719C + EGFR S768I (2)
EGFR G719S + EGFR L861Q (2)
EGFR G874S (2)
EGFR H1975 (2)
EGFR K708R (2)
EGFR L747-S752 del (2)
EGFR L747_A750delinsP (2)
EGFR L833F + EGFR L861Q (2)
EGFR L858R + EGFR A871G (2)
EGFR L858R + EGFR L718Q (2)
EGFR L858R + RBM10 Y36* (2)
EGFR L858R + TP53 mutation (2)
EGFR L860R (2)
EGFR L861R (2)
EGFR N771delinsKG (2)
EGFR P596L (2)
EGFR R165Q (2)
EGFR R222C (2)
EGFR S645C + EGFR L858R (2)
EGFR T790M + KRAS mutation (2)
EGFR T790M + PIK3CA H1047R (2)
EGFR V802I + KRAS mutation (2)
EGFR exon 19 duplication (2)
EGFR exon 19 insertion (2)
EGFR exon 20 insertion + EGFR T790M (2)
EGFR mutation + ATM mutation (2)
EGFR mutation + BRAF V600 (2)
EGFR mutation + CDKN2A mutation (2)
EGFR mutation + EGFR T790M (2)
EGFR mutation + MET mutation (2)
EGFR mutation + NRAS Q61K (2)
EGFR mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + ARID1A mutation (2)
EGFR mutation + TP53 mutation + BRCA1 mutation (2)
EGFR mutation + TP53 mutation + NF1 mutation (2)
EGFR mutation + TP53 mutation + PTEN mutation (2)
EGFR mutation + TP53 mutation + RB1 mutation (2)
EGFR T790L (2)
EGFR delE709_T710insD (2)
KRAS mutation + EGFR wild-type (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
KEAP1 mutation + KRAS mutation (2)
KRAS A146V (2)
KRAS A59 (2)
KRAS A59S (2)
KRAS G12C + KEAP1 mutation (2)
KRAS G12D + KRAS G12V (2)
KRAS G13A (2)
KRAS G13C (2)
KRAS G13D + BRAF mutation (2)
KRAS K117 (2)
KRAS Q99L (2)
KRAS R68M (2)
KRAS exon 12 mutation (2)
KRAS exon 2 wild-type (2)
KRAS exon 3 mutation (2)
KRAS exon 4 mutation (2)
KRAS mutation + STK11 mutation + KEAP1 mutation (2)
KRAS mutation + TP53 wild-type (2)
PIK3CA mutation + KRAS mutation (2)
STK11 mutation + KEAP1 mutation + KRAS G12C (2)
ALK L1152R + EGFR mutation (1)
ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)
BRAF mutation + EGFR mutation (1)
CDK4 mutation + EGFR mutation (1)
DDR + EGFR mutation (1)
EGFR 181946 C>T (1)
EGFR A289V (1)
EGFR A750P (1)
EGFR A763V (1)
EGFR A767_V769dupASV (1)
EGFR A767dupASV (1)
EGFR A859T (1)
EGFR C796S (1)
EGFR C796S + EGFR V802I (1)
EGFR C797S + EGFR C796S (1)
EGFR C797S + EGFR exon 20 insertion (1)
EGFR D770_N771insGL (1)
EGFR D770_N771insGT + EGFR V774_C775insHV (1)
EGFR E690K (1)
EGFR E709A + EGFR G719C (1)
EGFR E709G (1)
EGFR E709Q (1)
EGFR E746 (1)
EGFR E746G (1)
EGFR E746_T751delinsl (1)
EGFR E758D (1)
EGFR E884K (1)
EGFR G2607A (1)
EGFR G709T (1)
EGFR G719A + EGFR I706T (1)
EGFR G719A + EGFR L833V (1)
EGFR G719A + EGFR R776C (1)
EGFR G719A + EGFR S768I (1)
EGFR G719A + EGFR T790M (1)
EGFR G719C + EGFR E709V (1)
EGFR G719D (1)
EGFR G719S + EGFR S768I (1)
EGFR G719X + EGFR E709F (1)
EGFR G719X + EGFR L861Q + EGFR S768I (1)
EGFR G719X + TP53 mutation (1)
EGFR G724S + EGFR R776H (1)
EGFR G735R (1)
EGFR G796S (1)
EGFR G836S (1)
EGFR H773L + EGFR V774M (1)
EGFR H773_V774insNPH (1)
EGFR H773delinsNPY (1)
EGFR H773delinsYNPY (1)
EGFR H835L (1)
EGFR I744_K745insKIPVAI (1)
EGFR K467T (1)
EGFR K757R (1)
EGFR L718V + TP53 V727M + EGFR L858R (1)
EGFR L746_T70delinsS (1)
EGFR L746_T750del (1)
EGFR L747S (1)
EGFR L747_A750>P (1)
EGFR L747_P753delinsS (1)
EGFR L747_T751delinsP (1)
EGFR L747_T751delinsS (1)
EGFR L747_T753delinsS (1)
EGFR L833V (1)
EGFR L8585R + EGFR T790M + RBM10 G840fs*7 (1)
EGFR L858R + ALK R1275Q (1)
EGFR L858R + ALK rearrangement (1)
EGFR L858R + EGFR C797S (1)
EGFR L858R + EGFR D761Y (1)
EGFR L858R + EGFR E709G (1)
EGFR L858R + EGFR E709X (1)
EGFR L858R + EGFR E709X + CTNNB1 mutation (1)
EGFR L858R + EGFR E884K (1)
EGFR L858R + EGFR L747V (1)
EGFR L858R + EGFR R776H (1)
EGFR L858R + EGFR S765I (1)
EGFR L858R + EGFR S768I (1)
EGFR L858R + EGFR T854A (1)
EGFR L858R + EGFR V843I (1)
EGFR L858R + EGFR exon 21 deletion (1)
EGFR L858R + FGF3 mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)
EGFR L858R + RBM10 2167-1 G>T (1)
EGFR L858R + RBM10 Q255* (1)
EGFR L858R + RBM10 Q595* (1)
EGFR L858R + TP53 R273C + HER-2 S442L (1)
EGFR L858R + TP53 wild-type (1)
EGFR L861P (1)
EGFR L861Q + EGFR exon 20 insertion (1)
EGFR L861Q + TP53 mutation (1)
EGFR L861Q + TP53 mutation + RB1 mutation (1)
EGFR L861X (1)
EGFR M277E (1)
EGFR M766Q (1)
EGFR M766_A767insASV (1)
EGFR N771_P772insH (1)
EGFR N771_P772insVal (1)
EGFR P546S (1)
EGFR P753S (1)
EGFR P772_H773insYNP (1)
EGFR P772_H773insYNP + EGFR H773Y (1)
EGFR P772_V774insPHV (1)
EGFR Q787Q (1)
EGFR R1052K (1)
EGFR R451C (1)
EGFR R776C + EGFR L861Q (1)
EGFR R776H (1)
EGFR R776H + EGFR C797S (1)
EGFR R776H + EGFR L861Q (1)
EGFR S464L (1)
EGFR S720I (1)
EGFR S752_I759del (1)
EGFR S768I + TP53 mutation (1)
EGFR S768_D770dup (1)
EGFR S768_D770dupSVD (1)
EGFR S768dupSVD (1)
EGFR S784F (1)
EGFR T263P (1)
EGFR T751_I759>S (1)
EGFR T790I (1)
EGFR T790M + BRAF V600E (1)
EGFR T790M + EGFR L792F (1)
EGFR T790M + EGFR L833V + EGFR H835L (1)
EGFR T790M + EGFR L861Q (1)
EGFR T790M + EGFR S768I + EGFR L858R (1)
EGFR T790M + HER-2 mutation (1)
EGFR T790M + KRAS G12V (1)
EGFR T790M + MET mutation (1)
EGFR T790M + PARP1 mutation (1)
EGFR T790M + PIK3CA Mutation (1)
EGFR T790M + TP53 R237C (1)
EGFR T854A + EGFR T790M (1)
EGFR T858R (1)
EGFR V769A (1)
EGFR V769_770insASV (1)
EGFR V774_C775insHV (1)
EGFR V786M (1)
EGFR V802I (1)
EGFR V834L (1)
EGFR Y764_V765insHH (1)
EGFR exon 18 mutation + EGFR exon 21 mutation (1)
EGFR exon 19 deletion + ALK mutation (1)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
EGFR exon 19 deletion + BRAF V600E (1)
EGFR exon 19 deletion + BRCA2 mutation (1)
EGFR exon 19 deletion + EGFR G724S + EGFR T790M (1)
EGFR exon 19 deletion + EGFR T790L (1)
EGFR exon 19 deletion + TP53 exon 8 mutation (1)
EGFR exon 19 deletion + TP53 mutation (1)
EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)
EGFR exon 20 insertion + EGFR G719X + EGFR L858R (1)
EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)
EGFR exon 20 insertion + TP53 G244A + SPTA1 mutation (1)
EGFR exon 20 mutation + EGFR V774M + EGFR S768I (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR exon 21 mutation + EGFR L858R (1)
EGFR mutation + ALK mutation (1)
EGFR mutation + BRAF G469A (1)
EGFR mutation + BRAF mutation + TP53 mutation (1)
EGFR mutation + CTBP2 rs376695472 (1)
EGFR mutation + CTBP2 rs945665113 (1)
EGFR mutation + EGFR T790M + EGFR C797S (1)
EGFR mutation + FAT3 mutation (1)
EGFR mutation + GRM8 mutation (1)
EGFR mutation + HLA-DRB5 rs1071748 (1)
EGFR mutation + HLA-DRB5 rs184278615 (1)
EGFR mutation + HLA-DRB5 rs20146916 (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation + KIR3DL1 rs199822561 (1)
EGFR mutation + KIR3DL1 rs200821495 (1)
EGFR mutation + KIR3DL1 rs72629105 (1)
EGFR mutation + KIR3DL2 rs973541788 (1)
EGFR mutation + LRP1B mutation (1)
EGFR mutation + MDM4 *32C>A (1)
EGFR mutation + MET Y1003N (1)
EGFR mutation + NOTCH1 mutation (1)
EGFR mutation + RB1 mutation (1)
EGFR mutation + SMAD4 mutation (1)
EGFR mutation + TP53 exon 6 mutation (1)
EGFR mutation + TP53 exon 7 mutation (1)
EGFR mutation + UBXN11 mutation (1)
EGFR mutation + ZNF217 mutation (1)
EGFR mutation+ IDH1 R132H (1)
EGFR rearrangement (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
EGFR wild-type + ALK wild-type + STK11 mutation (1)
EGFR wild-type + MET wild-type (1)
EGFR-SEPTIN14 rearrangement (1)
EGFR G729A + EGFR L858R (1)
EGFR T790M + TP53 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH2 R140W + EGFR L858R (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
MTOR L1433S + EGFR L858R + EGFR T790M (1)
ALK rearrangement + KRAS mutation (1)
APC mutation + KRAS mutation (1)
ARID1A mutation+ KRAS G12C (1)
BRAF V600E + KRAS G12R (1)
DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)
KIR2DS4 mutation + KRAS mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12C + ATM wild-type (1)
KRAS G12C + KRAS G12V (1)
KRAS G12C + SMARCA4 wild-type (1)
KRAS G12D + DNMT3A C559fsX (1)
KRAS G12V + BRAF V600E (1)
KRAS G12V + STK11 mutation (1)
KRAS G12V + TP53 mutation + APC mutation (1)
KRAS G60D (1)
KRAS G61 (1)
KRAS G61H + KRAS G12A (1)
KRAS N116H (1)
KRAS N116T (1)
KRAS Q22X (1)
KRAS Q61K (1)
KRAS Q61L (1)
KRAS S89P (1)
KRAS V12 (1)
KRAS exon 13 mutation (1)
KRAS mutation + ATM mutation (1)
KRAS mutation + KEAP1 mutation (1)
KRAS mutation + SMARCA4 mutation (1)
KRAS mutation + STK11 deletion + KEAP1 deletion (1)
KRAS mutation + STK11 mutation + TP53 mutation (1)
KRAS mutation + U2AF1 mutation (1)
KRAS mutation + KMT2C mutation (1)
MAP2K1 G128D + KRAS mutation (1)
MET exon 14 mutation + KRAS G12A (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PTPN11 mutation + KRAS wild-type (1)
STK11 mutation + KEAP1 mutation + KRAS wild-type (1)
EGFR A839V (0)
EGFR E709A (0)
EGFR E709F (0)
EGFR G779C (0)
EGFR G873E (0)
EGFR H773L (0)
EGFR K754E (0)
EGFR L747_S752del (0)
EGFR L747_T750del (0)
EGFR L858R + EGFR G779S (0)
EGFR L858R + RBM10 Q255 (0)
EGFR R776C (0)
EGFR S765I (0)
EGFR T785A + EGFR L861Q + EGFR H297_E298 (0)
EGFR V774M (0)
EGFR mutation + APC mutation (0)
EGFR rs4947492 (0)
MET exon 14 skipping mutation + EGFR G709T (0)
BRAF V600E + KRAS G12D (0)
CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)
CDKN2A mutation + KRAS mutation (0)
KRAS A146P (0)
KRAS A59 (0)
KRAS G61H (0)
KRAS mutation + TP53 mutation (0)
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VERI cancer hierarchy
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EGFR mutation + KRAS mutation
Lung Non-Squamous Non-Small Cell Cancer
EGFR mutation + KRAS mutation
Lung Non-Squamous Non-Small Cell Cancer
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor
Sensitive
:
C3
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor
Sensitive
:
C3
EGFR mutation + KRAS mutation
Non Small Cell Lung Cancer
EGFR mutation + KRAS mutation
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
Tyrosine kinase inhibitor
Resistant: C3 – Early Trials
Tyrosine kinase inhibitor
Resistant
:
C3
EGFR mutation + KRAS mutation
Lung Adenocarcinoma
EGFR mutation + KRAS mutation
Lung Adenocarcinoma
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR inhibitor
Resistant: C3 – Early Trials
EGFR inhibitor
Resistant
:
C3
EGFR mutation + KRAS mutation
Colorectal Cancer
EGFR mutation + KRAS mutation
Colorectal Cancer
cetuximab
Resistant: D – Preclinical
cetuximab
Resistant
:
D
cetuximab
Resistant: D – Preclinical
cetuximab
Resistant
:
D
^
^
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