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GENE:

CDK6 (Cyclin-dependent kinase 6)

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CDK6 overexpression	Estrogen Receptor Positive Breast Cancer	CDK6 overexpression	Estrogen Receptor Positive Breast Cancer	fulvestrant Resistant: C3 – Early Trials fulvestrant Resistant : C3	fulvestrant Resistant: C3 – Early Trials fulvestrant Resistant : C3
HER-2 mutation + CDK6 mutation	Ampulla of Vater Carcinoma	HER-2 mutation + CDK6 mutation	Ampulla of Vater Carcinoma	palbociclib + pertuzumab + abemaciclib + ribociclib + trastuzumab/hyaluronidase-oysk Sensitive: C3 – Early Trials palbociclib + pertuzumab + abemaciclib + ribociclib + trastuzumab / hyaluronidase-oysk Sensitive : C3	palbociclib + pertuzumab + abemaciclib + ribociclib + trastuzumab/hyaluronidase-oysk Sensitive: C3 – Early Trials palbociclib + pertuzumab + abemaciclib + ribociclib + trastuzumab / hyaluronidase-oysk Sensitive : C3
ER positive + CDK6 overexpression	HER2 Negative Breast Cancer	ER positive + CDK6 overexpression	HER2 Negative Breast Cancer	palbociclib Resistant: C3 – Early Trials palbociclib Resistant : C3	palbociclib Resistant: C3 – Early Trials palbociclib Resistant : C3
FGFR1 amplification + RAF1 ampliﬁcation + CDK6 ampliﬁcation	Small Cell Lung Cancer	FGFR1 amplification + RAF1 ampliﬁcation + CDK6 ampliﬁcation	Small Cell Lung Cancer	nivolumab Resistant: C4 – Case Studies nivolumab Resistant : C4	nivolumab Resistant: C4 – Case Studies nivolumab Resistant : C4
FGFR1 amplification + RAF1 ampliﬁcation + CDK6 ampliﬁcation	Small Cell Lung Cancer	FGFR1 amplification + RAF1 ampliﬁcation + CDK6 ampliﬁcation	Small Cell Lung Cancer	ponatinib Resistant: C4 – Case Studies ponatinib Resistant : C4	ponatinib Resistant: C4 – Case Studies ponatinib Resistant : C4
EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification	Lung Non-Small Cell Squamous Cancer	EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification	Lung Non-Small Cell Squamous Cancer	osimertinib Resistant: C4 – Case Studies osimertinib Resistant : C4	osimertinib Resistant: C4 – Case Studies osimertinib Resistant : C4
CDK6 overexpression	Multiple Myeloma	CDK6 overexpression	Multiple Myeloma	lenalidomide Resistant: D – Preclinical lenalidomide Resistant : D	lenalidomide Resistant: D – Preclinical lenalidomide Resistant : D