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BIOMARKER:

EGFR H1975

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Entrez ID:

Related biomarkers:

‹

EGFR exon 19 deletion (79)

EGFR amplification (52)

EGFR exon 18 deletion (3)

EGFR exon 2-7 deletion + EGFR amplification (2)

EGFR amplification + ERBB2 amplification (1)

EGFR exon 19 deletion + HER-2 amplification (1)

EGFR exon 21 deletion (1)

EGFR T790M + exon 19 deletion (0)

EGFR amplifcation (0)

EGFR exon 19 deletion (79)

EGFR amplification (52)

EGFR exon 18 deletion (3)

EGFR exon 2-7 deletion + EGFR amplification (2)

EGFR amplification + ERBB2 amplification (1)

EGFR exon 19 deletion + HER-2 amplification (1)

EGFR exon 21 deletion (1)

EGFR T790M + exon 19 deletion (0)

EGFR amplifcation (0)

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over3years

First, #VEGF is highly expressed in #EGFR mutant cell lines (HCC827, H3255) and TKI therapy drops VEGF mRNA while in resistant setting (H1975 with T790M), erlotinib has no impact on high VEGF levels. In EGFRmt NSCLC, VEGF secretion is EGFR dependent. (@StephenVLiu)

over 3 years ago

Preclinical

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EGFR (Epidermal growth factor receptor)

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EGFR mutation • EGFR T790M • EGFR expression • EGFR overexpression • EGFR H1975

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erlotinib