"We tested plasma samples from the Erbitux Metastatic Colorectal Cancer Strategy (ERMES) phase III trial of FOLFIRI+Cetuximab in first-line treatment of RAS/BRAF wild-type mCRC...These data confirm that the occurrence of RAS/BRAF mutations in mCRC patients receiving anti-EGFR agents is relatively frequent. However, the cfDNA dynamics of RAS mutations in patients treated with anti-EGFR agents plus polychemotherapy are complex and might not be directly associated with resistance to treatment."
over 2 years ago
Journal
|
BRAF (B-raf proto-oncogene)
|
BRAF mutation • BRAF wild-type
|
Oncomine™ Pan-Cancer Cell-Free Assay • Idylla™ ctKRAS Mutation Test • Idylla™ ctNRAS-BRAF Mutation Test