^
2years
Dynamics of RAS/BRAF Mutations in cfDNA from Metastatic Colorectal Carcinoma Patients Treated with Polychemotherapy and Anti-EGFR Monoclonal Antibodies. (PubMed, Cancers (Basel))
"We tested plasma samples from the Erbitux Metastatic Colorectal Cancer Strategy (ERMES) phase III trial of FOLFIRI+Cetuximab in first-line treatment of RAS/BRAF wild-type mCRC...These data confirm that the occurrence of RAS/BRAF mutations in mCRC patients receiving anti-EGFR agents is relatively frequent. However, the cfDNA dynamics of RAS mutations in patients treated with anti-EGFR agents plus polychemotherapy are complex and might not be directly associated with resistance to treatment."
Journal
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BRAF (B-raf proto-oncogene)
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BRAF mutation • BRAF wild-type
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Oncomine™ Pan-Cancer Cell-Free Assay • Idylla™ ctKRAS Mutation Test • Idylla™ ctNRAS-BRAF Mutation Test
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Erbitux (cetuximab) • 5-fluorouracil • leucovorin calcium