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    DRUG:

    tambotatug pelitecan (RG6919)

    i
    Other names: RG6919, YL201, YL-201, Tam-peli
    Associations

    News

    Trials
    Company:
    MediLink, Roche
    Drug class:
    Topoisomerase I inhibitor, B7-H3-targeted antibody-drug conjugate
    Related drugs:
    Associations

    News

    Trials
    29d
    A Phase III Study of YL201 in Relapsed Small Cell Lung Cancer (clinicaltrials.gov)
    P3, N=438, Active, not recruiting, MediLink Therapeutics (Suzhou) Co., Ltd. | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    CD276 (CD276 Molecule)
    |
    topotecan • tambotatug pelitecan (RG6919)
    1m
    DeLLphi-310: Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC) (clinicaltrials.gov)
    P1, N=29, Active, not recruiting, Amgen | N=200 --> 29
    Enrollment change
    |
    Imfinzi (durvalumab) • Imdelltra (tarlatamab-dlle) • tambotatug pelitecan (RG6919)
    2ms
    DeLLphi-310: Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC) (clinicaltrials.gov)
    P1, N=200, Active, not recruiting, Amgen | Suspended --> Active, not recruiting
    Enrollment closed
    |
    Tecentriq (atezolizumab) • Imfinzi (durvalumab) • Imdelltra (tarlatamab-dlle) • tambotatug pelitecan (RG6919)
    2ms
    YL201-INT-102-02: A Study of YL201 in Combination with Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors (2025-523742-27-00)
    P1/2, N=133, Not yet recruiting, Medilink Therapeutics (Suzhou) Co. Ltd. | N=51 --> 133
    Enrollment change
    |
    Tecentriq (atezolizumab) • tambotatug pelitecan (RG6919)
    3ms
    A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=118, Recruiting, MediLink Therapeutics (Suzhou) Co., Ltd. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Tecentriq (atezolizumab) • tambotatug pelitecan (RG6919)
    3ms
    DeLLphi-310: Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC) (clinicaltrials.gov)
    P1, N=200, Suspended, Amgen | Recruiting --> Suspended
    Trial suspension
    |
    Tecentriq (atezolizumab) • Imfinzi (durvalumab) • Imdelltra (tarlatamab-dlle) • tambotatug pelitecan (RG6919)
    3ms
    A Phase III Study Evaluating YL201 Versus ICC in 2L ESCC (clinicaltrials.gov)
    P3, N=440, Not yet recruiting, MediLink Therapeutics (Suzhou) Co., Ltd.
    New P3 trial
    |
    paclitaxel • docetaxel • irinotecan • tambotatug pelitecan (RG6919)
    3ms
    YL201-INT-102-02: A Study of YL201 in Combination with Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors (2025-523742-27-00)
    P1/2, N=35, Not yet recruiting, Medilink Therapeutics (Suzhou) Co. Ltd.
    New P1/2 trial
    |
    Tecentriq (atezolizumab) • tambotatug pelitecan (RG6919)
    3ms
    A Study YL201 in Patients With Selected Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=990, Active, not recruiting, MediLink Therapeutics (Suzhou) Co., Ltd. | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    tambotatug pelitecan (RG6919)
    4ms
    A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=118, Not yet recruiting, MediLink Therapeutics (Suzhou) Co., Ltd.
    New P1/2 trial
    |
    Tecentriq (atezolizumab) • tambotatug pelitecan (RG6919)
    7ms
    A Study of YL201 in Combination With Toripalimab and With or Without Cisplatin in Nasopharyngeal Carcinoma. (clinicaltrials.gov)
    P1/2, N=202, Recruiting, MediLink Therapeutics (Suzhou) Co., Ltd.
    New P1/2 trial
    |
    cisplatin • Loqtorzi (toripalimab-tpzi) • tambotatug pelitecan (RG6919)
    7ms
    A Study of YL201 and Ivonescimab (AK112) in Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=260, Recruiting, MediLink Therapeutics (Suzhou) Co., Ltd. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Idafang (ivonescimab) • tambotatug pelitecan (RG6919)