R54 impairs Tregs function in primary RCC patients targeting PTEN/PI3K/AKT pathway, reducing TSDR demethylation and FOXP3 and DNMT1 expression. Thus, CXCR4 targeting is a strategy to inhibit Tregs activity in the RCC tumour microenvironment.

4 days ago

Journal • PD(L)-1 Biomarker • IO biomarker

PTEN (Phosphatase and tensin homolog) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • IL2RA (Interleukin 2 receptor, alpha) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • DNMT1 (DNA methyltransferase 1) • TGFB1 (Transforming Growth Factor Beta 1) • FOXP3 (Forkhead Box P3) • CD40LG (CD40 ligand) • NRP1 (Neuropilin 1)

CXCR4 expression • DNMT1 expression

triciribine phosphate (PTX-200)

A Study of PTX-200 (Triciribine) Plus Cytarabine in Refractory or Relapsed Acute Leukemia (clinicaltrials.gov)

P1/2, N=33, Completed, Prescient Therapeutics, Ltd. | Recruiting --> Completed | Trial completion date: Dec 2021 --> Mar 2024 | Trial primary completion date: Dec 2021 --> Oct 2023

1 month ago

Trial completion • Trial completion date • Trial primary completion date

cytarabine • triciribine phosphate (PTX-200)

5ms

The Role of ZNF275/AKT Pathway in Carcinogenesis and Cisplatin Chemosensitivity of Cervical Cancer Using Patient-Derived Xenograft Models. (PubMed, Cancers (Basel))

Collectively, the current findings demonstrated that ZNF275 serves as a sufficiently predictive indicator of the therapeutic effectiveness of the combined treatment of triciribine and cisplatin on cervical cancer. Combining triciribine with cisplatin greatly broadens the therapeutic options for cervical cancer expressing high ZNF275, but further research is needed to confirm these results.

5 months ago

Preclinical • Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2)

cisplatin • triciribine phosphate (PTX-200)

11ms

Pharmacological inhibiting STAT5 for the treatment of FLT3-ITD-positive acute myeloid leukemia with triciribine phosphate monohydrate. (PubMed, MedComm (2020))

No abstract available

11 months ago

Journal

STAT5A (Signal Transducer And Activator Of Transcription 5A)

triciribine phosphate (PTX-200)

11ms

Acquired AKT-inhibitor Resistance Is Mediated by ATP-binding Cassette Transporters in Endometrial Carcinoma. (PubMed, Anticancer Res)

In this study, we established a triciribine-resistant cell line from HEC-151 cells. Our data suggest that the mechanism of drug resistance in endometrial cancer cells is attributed to the increased expression of ABC transporters.

11 months ago

Journal

ABCB1 (ATP Binding Cassette Subfamily B Member 1) • ABCC1 (ATP Binding Cassette Subfamily C Member 1)

ABCC1 overexpression

triciribine phosphate (PTX-200)

3years

A Study of PTX-200 (Triciribine) Plus Cytarabine in Refractory or Relapsed Acute Leukemia (clinicaltrials.gov)

P1/2, N=40, Recruiting, Prescient Therapeutics, Ltd. | Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021

3 years ago

Trial completion date • Trial primary completion date

CD34 (CD34 molecule)

cytarabine • triciribine phosphate (PTX-200)

almost4years

PTX-200, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide in Treating Patients With Stage IIB-IV Breast Cancer (clinicaltrials.gov)

P1/2, N=34, Terminated, Prescient Therapeutics, Ltd. | Active, not recruiting --> Terminated; criteria for continuing enrollment in Phase 2 portion was not met

almost 4 years ago

Clinical • Trial termination

HER-2 (Human epidermal growth factor receptor 2)

ER positive • HR positive

paclitaxel • doxorubicin hydrochloride • triciribine phosphate (PTX-200)

4years

Heat shock protein 90 relieves heat stress damage of myocardial cells by regulating Akt and PKM2 signaling in vivo. (PubMed, Int J Mol Med)

The present study was based on the high expression of Hsp90 during heat stress (HS) and involved inducing higher expression of Hsp90 using aspirin in mouse hearts...Protection by Hsp90 was weakened by blocking Akt activation using Triciribine, which could not be recovered by normal initiation of the PKM2 pathway. Furthermore, increased Hsp70 levels induced by Akt activation in myocardial cells may flow into the blood to resist heat stress. The results provided in vivo mechanistic evidence that in myocardial cells, Hsp90 resists heat stress via separate activation of the Akt‑Bcl‑2 and PKM2‑Bcl‑2 signaling pathways, which contribute toward preserving cardiac function and mitochondrial homeostasis.

4 years ago

Preclinical • Journal

BCL2 (B-cell CLL/lymphoma 2)

triciribine phosphate (PTX-200)

over4years

PTX-200, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide in Treating Patients With Stage IIB-IV Breast Cancer (clinicaltrials.gov)

P1/2, N=34, Active, not recruiting, Prescient Therapeutics, Ltd. | Trial completion date: Dec 2022 --> Feb 2020

over 4 years ago

Clinical • Trial completion date

HER-2 (Human epidermal growth factor receptor 2)

ER positive • HR positive

paclitaxel • doxorubicin hydrochloride • triciribine phosphate (PTX-200)

over4years

A Study of PTX-200 (Triciribine) Plus Cytarabine in Refractory or Relapsed Acute Leukemia (clinicaltrials.gov)

P1/2, N=40, Recruiting, Prescient Therapeutics, Ltd. | Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2019 --> Dec 2020

over 4 years ago

Trial completion date • Trial primary completion date

CD34 (CD34 molecule)

cytarabine • triciribine phosphate (PTX-200)