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DRUG:

dordaviprone (ONC201)

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Company:

Chimerix

Drug class:

AKT inhibitor, ERK inhibitor

Related drugs:

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H3.3K27M	Glioma	H3.3K27M	Glioma	ONC201 Sensitive: B - Late Trials ONC201 Sensitive : B	ONC201 Sensitive: B - Late Trials ONC201 Sensitive : B
H3.3K27M	Glioma	H3.3K27M	Glioma	bevacizumab + ONC201 Sensitive: C3 – Early Trials bevacizumab + ONC201 Sensitive : C3	bevacizumab + ONC201 Sensitive: C3 – Early Trials bevacizumab + ONC201 Sensitive : C3
EGFR overexpression	Glioblastoma	EGFR overexpression	Glioblastoma	ONC201 Resistant: D – Preclinical ONC201 Resistant : D	ONC201 Resistant: D – Preclinical ONC201 Resistant : D
AR splice variant 7	Prostate Cancer	AR splice variant 7	Prostate Cancer	darolutamide + ONC201 Resistant: D – Preclinical darolutamide + ONC201 Resistant : D	darolutamide + ONC201 Resistant: D – Preclinical darolutamide + ONC201 Resistant : D
KRAS G12D	Pancreatic Cancer	KRAS G12D	Pancreatic Cancer	ONC201 Sensitive: D – Preclinical ONC201 Sensitive : D	ONC201 Sensitive: D – Preclinical ONC201 Sensitive : D