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DRUG:

Kimmtrak (tebentafusp-tebn)

i
Other names: IMCgp100, IMC-gp100, ImmTAC-gp100, IMC gp100, monoclonal T cell receptor anti-CD3 scFv fusion protein, ImmTACgp100, ImmTAC gp100
Company:
Immunocore, Medison
Drug class:
CD3 agonist, gp100 inhibitor
Related drugs:
17d
IMC-F106C-101: Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors (clinicaltrials.gov)
P1/2, N=727, Recruiting, Immunocore Ltd | Trial primary completion date: Jun 2026 --> Feb 2026
Trial primary completion date
|
HLA-A (Major Histocompatibility Complex, Class I, A) • PRAME (Preferentially Expressed Antigen In Melanoma)
|
HLA-A*02
|
Keytruda (pembrolizumab) • Avastin (bevacizumab) • Kimmtrak (tebentafusp-tebn) • brenetafusp (IMC-F106C)
22d
Neoadjuvant Tebentafusp for Uveal Melanoma (clinicaltrials.gov)
P2, N=19, Not yet recruiting, Thomas Jefferson University | Trial completion date: Dec 2028 --> Apr 2029 | Initiation date: Sep 2024 --> Jan 2025 | Trial primary completion date: Jun 2025 --> Oct 2025
Trial completion date • Trial initiation date • Trial primary completion date • Metastases
|
Kimmtrak (tebentafusp-tebn)
29d
Chondroitin Sulfate Proteoglycan 4 (CSPG4) as an Emerging Target for Immunotherapy to Treat Melanoma. (PubMed, Cancers (Basel))
Additionally, apart from Tebentafusp, which is approved for the treatment of uveal melanoma, there is a lack of immunotherapies directly focused on melanoma cells...Obstacles preventing that progress include limited knowledge of CSPG4 function in human cancer and a lack of in vivo models that adequately represent patient immune responses and human melanoma biology. Despite several challenges, immunotherapy directed to CSPG4-expressing melanoma harbors significant potential to transform the treatment landscape.
Review • Journal • IO biomarker
|
CSPG4 (Chondroitin Sulfate Proteoglycan 4)
|
Kimmtrak (tebentafusp-tebn)
1m
Tebentafusp-tebn With LDT in Metastatic UM (clinicaltrials.gov)
P1/2, N=109, Not yet recruiting, Thomas Jefferson University
New P1/2 trial
|
carmustine • Kimmtrak (tebentafusp-tebn) • Leukine (sargramostim)
1m
New P2 trial
|
Kimmtrak (tebentafusp-tebn) • TheraSphere (yttrium 90 microspheres)
1m
Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches (PubMed, Mol Biol (Mosk))
New drugs undergoing clinical trials are mostly targeted drugs designed to inhibit the protein products of mutant genes or immunotherapeutic agents designed to stimulate the immune response against specific antigens. In addition to these approaches, potential therapeutic targets of epigenetic regulation of UM development are considered in the review.
Review • Journal • IO biomarker
|
GNAQ (G Protein Subunit Alpha Q) • SF3B1 (Splicing Factor 3b Subunit 1) • BAP1 (BRCA1 Associated Protein 1) • GNA11 (G Protein Subunit Alpha 11) • EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked)
|
GNAQ mutation • SF3B1 mutation • BAP1 mutation
|
Kimmtrak (tebentafusp-tebn)
1m
Identifying biomarkers for treatment of uveal melanoma by T cell engager using a QSP model. (PubMed, NPJ Syst Biol Appl)
Tebentafusp, a bispecific T cell engager (TCE) approved for metastatic UM, showed potential in clinical trials, but the objective response rate remains modest...Quantification of predictive power suggested a limited predictive power for single pre-treatment biomarkers, which was improved by early on-treatment biomarkers and combination of predictive biomarkers. Ultimately, this QSP model could facilitate biomarker-guided patient selection, improving clinical trial efficiency and UM treatment outcomes.
Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • TMB (Tumor Mutational Burden) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CD4 (CD4 Molecule)
|
PD-L1 expression • TMB-L
|
Kimmtrak (tebentafusp-tebn)
2ms
Clinical and pathological characterization of Tebentafusp-associated skin toxicity - a cohort study with 33 patients. (PubMed, J Am Acad Dermatol)
Tebentafusp frequently induced cutaneous reactions. Pathogenesis is likely due to binding of tebentafusp to stimulated melanocytes in the skin followed by infiltration and activation of lymphocytes. Development of treatment induced skin reactions may be associated with survival benefit.
Journal
|
CD8 (cluster of differentiation 8)
|
Kimmtrak (tebentafusp-tebn)
2ms
T Cell-Engaging Bispecific Antibodies Targeting gp100 and PRAME: Expanding Application from Uveal Melanoma to Cutaneous Melanoma. (PubMed, Pharmaceutics)
Continued clinical trials will provide additional insights into the impact of tebentafusp on treatment-resistant metastatic cutaneous melanoma. Furthermore, we are exploring the potential of T cell engagers directed against the cancer testis antigen PRAME, which could have widespread utility in the treatment of cutaneous melanoma as well as other PRAME-expressing malignancies.
Review • Journal
|
PRAME (Preferentially Expressed Antigen In Melanoma)
|
Kimmtrak (tebentafusp-tebn)
3ms
Tailoring surveillance imaging in uveal melanoma based on individual metastatic risk. (PubMed, Can J Ophthalmol)
Customizing uveal melanoma surveillance to match metastatic risks could transform current practices, ensuring more precise protocols, reducing unnecessary examinations, and directing health care resources to those in greatest need.
Journal • Metastases
|
SF3B1 (Splicing Factor 3b Subunit 1) • BAP1 (BRCA1 Associated Protein 1) • EIF1AX (Eukaryotic Translation Initiation Factor 1A X-Linked)
|
Kimmtrak (tebentafusp-tebn)
4ms
Enrollment change • Trial withdrawal • Combination therapy • IO biomarker • Metastases
|
BRAF (B-raf proto-oncogene) • HLA-A (Major Histocompatibility Complex, Class I, A)
|
Imfinzi (durvalumab) • Imjudo (tremelimumab) • Kimmtrak (tebentafusp-tebn)
4ms
Radiation and systemic immunotherapy for metastatic uveal melanoma: a clinical retrospective review. (PubMed, Front Oncol)
The only FDA approved immunotherapy medication for metastatic uveal melanoma is the HLA-A02:01 restricted bispecific T cell engager drug, Tebentafusp...Twenty-three (92%) patients received systemic therapy, 13 patients (52%) received ipilimumab-nivolumab as the first-line, while 4 patients (16%) received pembrolizumab...Within our cohort, there was no overall survival benefit for patients receiving treatment of metastatic disease within 6 months of mUM diagnosis, versus those electing later or no treatment at all. There was remarkable clinical activity of ipilimumab and nivolumab in a subset of patients with mUM, in agreement with prior studies, and metastatic PD-L1 positive tumors were associated with a prolonged survival.
Retrospective data • Review • Journal • Metastases
|
PD-L1 (Programmed death ligand 1) • HLA-A (Major Histocompatibility Complex, Class I, A)
|
Keytruda (pembrolizumab) • Opdivo (nivolumab) • Yervoy (ipilimumab) • Kimmtrak (tebentafusp-tebn)
4ms
5-methylthioadenosine phosphorylase (MTAP) loss in clinically advanced uveal melanoma (CAUM): A comprehensive genomic profiling (CGP) study (ESMO 2024)
Treatment options are limited to Tebentafusp in patients with HLA-A*02:01 mutation with immunotherapy and chemotherapy yielding poor results...In a recent phase I trial of a PRMT5 inhibitor, PRT811, clinical activity was described in cases of CAUM. 676 CAUM and 9666 CASM patients underwent hybrid capture based CGP to evaluate genomic alterations (GA)... Although MTAP loss is less frequent in CAUM than in CASM, the recent evidence that this genomic alteration predicts responsiveness to PRMT5 inhibition is noteworthy. This highlights the importance of further investigating this biomarker for patients with this rare and clinically aggressive type of cancer.
Clinical • Tumor mutational burden • PD(L)-1 Biomarker • MSi-H Biomarker • IO biomarker • Metastases
|
PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene) • TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • NF1 (Neurofibromin 1) • GNAQ (G Protein Subunit Alpha Q) • HLA-A (Major Histocompatibility Complex, Class I, A) • MTAP (Methylthioadenosine Phosphorylase) • BAP1 (BRCA1 Associated Protein 1) • GNA11 (G Protein Subunit Alpha 11) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B)
|
PD-L1 expression • MSI-H/dMMR • PD-L1 overexpression • BRAF mutation • HLA-A*02
|
PD-L1 IHC 22C3 pharmDx
|
Kimmtrak (tebentafusp-tebn) • P-500
4ms
Tebentafusp induces a T cell driven rash in melanocyte-bearing skin as an adverse event consistent with the mechanism of action. (PubMed, J Invest Dermatol)
When adjusted for baseline prognostic features, patients with rash within the first week of tebentafusp treatment had the same overall survival compared to patients without a rash in the phase 3 randomized trial IMCgp100-202 (HR 0.84; 95% CI 0.53-1.32). In summary, skin rash is an off-tumour, on-target effect of tebentafusp against gp100+ melanocytes, in line with the mechanism of action.
Journal • Adverse events
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
Kimmtrak (tebentafusp-tebn)
4ms
Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma (clinicaltrials.gov)
P2; Trial completion date: Jun 2029 --> Sep 2029 | Initiation date: Jun 2024 --> Sep 2024 | Trial primary completion date: Jun 2026 --> Sep 2026
Trial completion date • Trial primary completion date • Trial initiation date • Circulating tumor DNA • Metastases
|
LAG3 (Lymphocyte Activating 3) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4)
|
Signatera™
|
Kimmtrak (tebentafusp-tebn)
5ms
Optimizing immune checkpoint blockade in metastatic uveal melanoma: exploring the association of overall survival and the occurrence of adverse events. (PubMed, Front Immunol)
In addition to tebentafusp, immune checkpoint blockade (ICB, PD-1 (+/-) CTLA-4 antibodies) is commonly used for metastatic UM, in particular in HLA-A 02:01-negative patients...Interestingly, irColitis and irHepatitis were significantly associated with longer OS (p=0.0031 and p=0.011, respectively). This data may indicate an association between irAE and favorable survival outcomes in patients with metastatic UM undergoing ICB treatment and suggests that a reduced tolerance to tumor antigens could be linked to reduced tolerance to self-antigens.
Journal • Adverse events • Checkpoint inhibition • Checkpoint block • Metastases
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
Kimmtrak (tebentafusp-tebn)
5ms
The Current State of Systemic Therapy of Metastatic Uveal Melanoma. (PubMed, Am J Clin Dermatol)
Notably, tebentafusp, an entirely novel class of anti-cancer drugs, has received official authorization for the treatment of metastatic UM. Further, promising data from targeted therapies independent of MEK-inhibitors, such as the combination of darovasertib and crizotinib, raise hope for additional options in metastatic UM in the future. This narrative review provides a timely and comprehensive overview of the current treatment landscape for metastatic UM.
Journal • Tumor mutational burden • Metastases
|
TMB (Tumor Mutational Burden) • HLA-A (Major Histocompatibility Complex, Class I, A)
|
Xalkori (crizotinib) • darovasertib (IDE196) • Kimmtrak (tebentafusp-tebn)
5ms
Long-term survival follow-up for tebentafusp in previously treated metastatic uveal melanoma. (PubMed, J Immunother Cancer)
This study represents the longest follow-up of a Tcell receptor bispecific to date and confirms the durable survival benefits achieved with tebentafusp in previously treated mUM with good tolerability long-term. A role for ctDNA reduction as an early indicator of clinical benefit was again suggested for patients treated with tebentafusp.
Clinical Trial,Phase I • Clinical Trial,Phase II • Journal • Metastases
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
Kimmtrak (tebentafusp-tebn)
6ms
Side effects of dermato-oncologic therapies (PubMed, Dermatologie (Heidelb))
Side effects can manifest themselves in all organ systems. Chronic side effects and long-term harm are possible, especially with ICIs, and require close therapy monitoring and patient education. Knowledge of the side effects and the temporal, sometimes delayed course of their occurrence are essential for diagnosis and prompt initiation of therapy.
Review • Journal • Adverse events
|
CCR4 (C-C Motif Chemokine Receptor 4)
|
imatinib • Poteligeo (mogamulizumab-kpkc) • Kimmtrak (tebentafusp-tebn)
6ms
Frequency of HLA-A*02:01 in the Brazilian population and its impact on uveal melanoma systemic treatment. (PubMed, Oncologist)
Despite tebentafusp has demonstrated promising results in the treatment of uveal melanoma, the number of patients to benefit from this new approach can strongly vary by ethnic and racial issues. New strategies for the systemic treatment of advanced uveal melanoma have to be developed and tested as this disease still represents an unmet medical need.
Journal
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
Kimmtrak (tebentafusp-tebn)
6ms
Neoadjuvant Tebentafusp for Uveal Melanoma (clinicaltrials.gov)
P2, N=19, Not yet recruiting, Thomas Jefferson University
New P2 trial • Metastases
|
Kimmtrak (tebentafusp-tebn)
7ms
Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors (clinicaltrials.gov)
P1/2, N=727, Recruiting, Immunocore Ltd | N=170 --> 727 | Trial completion date: Feb 2026 --> Jun 2026 | Trial primary completion date: Feb 2024 --> Jun 2026
Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Checkpoint inhibition
|
HLA-A (Major Histocompatibility Complex, Class I, A) • PRAME (Preferentially Expressed Antigen In Melanoma)
|
HLA-A*02
|
Keytruda (pembrolizumab) • Avastin (bevacizumab) • Kimmtrak (tebentafusp-tebn) • brenetafusp (IMC-F106C)
8ms
Updates in the Management of Uveal Melanoma. (PubMed, Cancer J)
The evolving landscape includes promising systemic treatments, such as tebentafusp, a novel immune-modulating bispecific fusion protein, and targeted therapies...Although recent progress has improved outcomes, ongoing research aims to address the unique challenges of UM and develop effective therapies, particularly for HLA-A*02:01-negative patients who represent a significant unmet medical need. This review comprehensively discusses the molecular characteristics of UM, risk stratification methods, and the current and future spectrum of regional and systemic therapeutic modalities.
Journal • IO biomarker
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
HLA-A*02
|
Kimmtrak (tebentafusp-tebn)
8ms
Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma (clinicaltrials.gov)
P2; Trial completion date: Nov 2028 --> Jun 2029 | Initiation date: Nov 2023 --> Jun 2024 | Trial primary completion date: Nov 2026 --> Jun 2026
Trial completion date • Trial primary completion date • Trial initiation date • Circulating tumor DNA • Metastases
|
LAG3 (Lymphocyte Activating 3) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4)
|
HLA-A*02:01
|
Signatera™
|
Kimmtrak (tebentafusp-tebn)
9ms
ATOM: Adjuvant Tebentafusp in High Risk Ocular Melanoma (clinicaltrials.gov)
P3, N=290, Not yet recruiting, European Organisation for Research and Treatment of Cancer - EORTC
New P3 trial • Metastases
|
Kimmtrak (tebentafusp-tebn)
10ms
The treatment of Advanced Melanoma: Current approaches and new challenges. (PubMed, Crit Rev Oncol Hematol)
Ipilimumab plus nivolumab has achieved the best median overall survival, exceeding 70 months. However, the introduction of new ICIs, like relatlimab, has added complexity to first-line therapy decisions...We also provide the latest insights into the treatment of rare melanoma subtypes, such as uveal melanoma, where tebentafusp has shown promising improvements in overall survival for metastatic uveal melanoma patients. This review provides invaluable insights for clinicians, enabling informed treatment choices and deepening our understanding of the multifaceted challenges associated with advanced melanoma management.
Review • Journal • PD(L)-1 Biomarker • IO biomarker • Metastases
|
PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene)
|
PD-L1 expression • BRAF mutation
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Kimmtrak (tebentafusp-tebn) • relatlimab (BMS-986016)
10ms
Phase classification • Combination therapy • IO biomarker • Metastases
|
BRAF (B-raf proto-oncogene) • HLA-A (Major Histocompatibility Complex, Class I, A)
|
BRAF mutation • HLA-A*02:01 • HLA-A*02
|
Imfinzi (durvalumab) • Imjudo (tremelimumab) • Kimmtrak (tebentafusp-tebn)
11ms
Patterns of radiological response to tebentafusp in patients with metastatic uveal melanoma. (PubMed, Melanoma Res)
Detectable ctDNA at baseline did not correlate with progression. Early response to tebentafusp may be incompletely captured by conventional imaging, leading to a need to consider both tumor morphology and metabolism.
Journal • Metastases
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
HLA-A*02:01 • HLA-A*02
|
Kimmtrak (tebentafusp-tebn)
12ms
Overall Survival From Tebentafusp Versus Nivolumab Plus Ipilimumab in First Line Metastatic Uveal Melanoma: A Propensity Score Weighted Analysis. (PubMed, Ann Oncol)
Tebentafusp was previously shown to provide an OS benefit compared to checkpoint inhibitors or chemotherapy in untreated mUM. Propensity score analysis demonstrated a similar OS benefit for tebentafusp compared with N+I. These data further support tebentafusp as the standard of care in previously untreated HLA-A*02:01+ adult patients with mUM.
Journal • Metastases
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
HLA-A*02
|
Keytruda (pembrolizumab) • Opdivo (nivolumab) • Yervoy (ipilimumab) • Kimmtrak (tebentafusp-tebn)
1year
Validation of a tumor-informed HLA typing assay to support drug development and clinical decision making (AMP 2023)
Tebentafusp-tebn (Kimmtrak), a bispecific HLA-directed CD3 T cell engager, is FDA approved specifically for patients with uveal melanoma and HLA-A*02:01, whereas HLA-A*03 is linked to resistance to checkpoint inhibitors... We successfully validated the TSO500 HT assay to genotype HLA-A, -B, and -C from tumor samples to the field 2-level required for study eligibility. By including tumor-informed HLA allele haplotypes with CGIP results, clinicians and drug developers can get a better insight of a patient's immune phenotype to aid HLA-directed therapy selection in uveal melanoma and enrollment of other tumor types in HLA-restricted clinical trials.
Clinical • IO biomarker
|
HLA-A (Major Histocompatibility Complex, Class I, A) • HLA-B (Major Histocompatibility Complex, Class I, B) • HLA-C (Major Histocompatibility Complex, Class I, C)
|
HLA-A*02
|
TruSight Oncology 500 Assay
|
Kimmtrak (tebentafusp-tebn)
1year
Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous Melanoma (clinicaltrials.gov)
P1b/2, N=113, Completed, Immunocore Ltd | Active, not recruiting --> Completed | N=312 --> 113 | Trial completion date: Nov 2023 --> Jun 2023
Trial completion • Enrollment change • Trial completion date • Combination therapy • IO biomarker • Metastases
|
BRAF (B-raf proto-oncogene) • HLA-A (Major Histocompatibility Complex, Class I, A)
|
PD-L1 expression • BRAF mutation • HLA-A*02:01 • HLA-A*02
|
Imfinzi (durvalumab) • Imjudo (tremelimumab) • Kimmtrak (tebentafusp-tebn)
1year
Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma. (PubMed, N Engl J Med)
This 3-year analysis supported a continued long-term benefit of tebentafusp for overall survival among adult HLA-A*02:01-positive patients with previously untreated metastatic uveal melanoma. (Funded by Immunocore; IMCgp100-202 ClinicalTrials.gov number, NCT03070392; EudraCT number, 2015-003153-18.).
Journal • Metastases
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
HLA-A*02:01 • HLA-A*02 • HLA-A2 positive
|
Keytruda (pembrolizumab) • Yervoy (ipilimumab) • dacarbazine • Kimmtrak (tebentafusp-tebn)
1year
Tumor lysis syndrome induced by tebentafusp. (PubMed, Immunotherapy)
Tebentafusp, a bispecific T-cell receptor fusion protein directed against gp100 and CD3, can improve survival in patients with metastatic uveal melanoma and was recently approved for the treatment of HLA-A*02:01-positive uveal melanoma patients. With adequate therapy, including the application of rasburicase, the patient made a full recovery. It is important to raise awareness of the adverse event profile of this new therapeutic approach among healthcare professionals to promptly recognize and treat side effects.
Journal
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
HLA-A*02:01 • HLA-A*02
|
Kimmtrak (tebentafusp-tebn)
1year
New P2 trial • Circulating tumor DNA • Metastases
|
LAG3 (Lymphocyte Activating 3) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4)
|
HLA-A*02:01
|
Signatera™
|
Kimmtrak (tebentafusp-tebn)
1year
Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous Melanoma (clinicaltrials.gov)
P1b/2, N=312, Active, not recruiting, Immunocore Ltd | Trial completion date: Jan 2025 --> Nov 2023 | Trial primary completion date: Jan 2025 --> Jul 2023 | Recruiting --> Active, not recruiting
Enrollment closed • Trial completion date • Trial primary completion date • Combination therapy • IO biomarker • Metastases
|
BRAF (B-raf proto-oncogene) • HLA-A (Major Histocompatibility Complex, Class I, A)
|
PD-L1 expression • BRAF mutation • HLA-A*02:01 • HLA-A*02
|
Imfinzi (durvalumab) • Imjudo (tremelimumab) • Kimmtrak (tebentafusp-tebn)
1year
Determinants of overall survival in patients with metastatic uveal melanoma. (PubMed, Cancer)
Metastatic uveal melanoma patients face limited treatment options and poor survival rates. Results from this retrospective analysis indicate that immune checkpoint inhibitors, such as anti-CTLA-4 and anti-PD-1 therapies, were associated with improved survival outcomes. Factors such as extrahepatic-only metastases, better baseline performance status, and female sex contributed to a more than 2-fold reduction in death risk. These findings highlight the potential of immunotherapy in treating metastatic uveal melanoma.
Retrospective data • Journal • Metastases
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Kimmtrak (tebentafusp-tebn)
1year
Treatment of uveal melanoma patients with gemcitabine and treosulfan: a retrospective analysis. (EADV 2023)
Tebentafusp is a relatively new licenced therapy option for HLA-A 02:01 positive advanced uveal melanoma. We conclude that gemcitabine and treosulfan treatment can delay tumour progression. Adjustments to the treatment dose are necessary in case of adverse events under therapy. Further investigations are needed to show which patients benefit from initial dose reduction in the treatment.
Retrospective data
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
HLA-A*02:01 • HLA-A*02
|
gemcitabine • Kimmtrak (tebentafusp-tebn) • Ovastat (treosulfan)
1year
Practical guidelines for the management of adverse events of the T cell engager bispecific tebentafusp. (PubMed, Eur J Cancer)
To minimise the risk of hypotension associated with CRS, patients should receive intravenous fluids before starting treatment. The monitoring of liver values is crucial, as patients may experience an increase in transaminases, which can even manifest as tumour lysis syndrome.
Journal • Adverse events
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
HLA-A*02
|
Kimmtrak (tebentafusp-tebn)
1year
Uveal melanoma: In the era of new treatments. (PubMed, Cancer Treat Rev)
This review provides a broad overview of the different therapeutic options for the management of localized or metastatic UM disease, with recently updated data. Despite the known limited efficacy of chemotherapy and immune checkpoint inhibitors (ICI), we discuss the first results of combined immunotherapies, the arrival of a new first-in-class immunomodulatory treatment Tebentafusp, in HLA-A*02:01 patients, avenues of research into targeted anti-tyrosine kinase therapies, and the growing use of ctDNA to guide treatment prescription.
Review • Journal
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
HLA-A*02
|
Kimmtrak (tebentafusp-tebn)
over1year
Tebentafusp reprograms immunosuppressive tumor-associated M2 macrophages towards anti-tumoral M1 macrophages (ESMO 2023)
Conclusions ImmTAC-mediated redirection of T cells reprograms pro-tumoral M2 macrophages towards anti-tumoral M1 macrophages in vitro and in tebentafusp-treated mUM patients. These results demonstrate how tebentafusp re-shapes the tumor microenvironment to enhance the anti-tumor activity of T cells.
IO biomarker
|
HLA-A (Major Histocompatibility Complex, Class I, A) • CD163 (CD163 Molecule) • IRF4 (Interferon regulatory factor 4) • CD40 (CD40 Molecule) • MRC1 (Mannose Receptor C-Type 1) • CD80 (CD80 Molecule)
|
HLA-A*02:01 • HLA-A*02 • CD163 expression • HLA-A2 positive • HLA-A positive
|
Kimmtrak (tebentafusp-tebn)
over1year
Effect of subsequent therapies including checkpoint inhibitors on overall survival in a phase III randomized trial of tebentafusp in first-line metastatic uveal melanoma: Long-term follow-up (ESMO 2023)
Tebe significantly improved overall survival (OS) compared to investigator's choice of pembrolizumab, ipilimumab or dacarbazine (HR 0.51) in first line (1L) mUM [NCT03070392]. Yang J. et al. ASCO 2019 , J. Clin Oncol 37:15_suppl, 9592.
Clinical • P3 data • Checkpoint inhibition • Metastases
|
HLA-A (Major Histocompatibility Complex, Class I, A)
|
HLA-A*02
|
Keytruda (pembrolizumab) • Yervoy (ipilimumab) • dacarbazine • Kimmtrak (tebentafusp-tebn)