Similarly, high expression of MSTRG.153013.3, an overexpressed alternative transcript, was associated with shortened MCL survival...WTS results were cross-validated with qRT-PCR of selected transcripts as well as linear correlation analyses. In conclusion, expression levels of oncogenesis-associated transcripts and/or the ratios of microenvironmental immunocytes in MCL tumors may be used to improve prognostication, thereby leading to better patient management and outcomes.

over 1 year ago

Journal

CD8 (cluster of differentiation 8) • CCND1 (Cyclin D1) • ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) • SOX11 (SRY-Box Transcription Factor 11) • VCAM1 (Vascular Cell Adhesion Molecule 1) • PCA3 (Prostate cancer associated 3)

CCND1 overexpression • CD8 expression • SOX11 expression

R1530

almost3years

Allele-Specific MicroRNA-Mediated Regulation of a Glycolysis Gatekeeper PDK1 in Cancer Metabolism. (PubMed, Cancers (Basel))

The present study is the first to report the regulation of the PDK1 gene by miRNAs in an allele-dependent manner and highlights the role of PDK1 in metabolic adaption associated with PCa progression.

almost 3 years ago

Journal

PDPK1 (3-Phosphoinositide dependent protein kinase 1)

R1530