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DRUG:

RAF265

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Company:

Novartis

Drug class:

BRAF inhibitor, VEGFR-2 inhibitor

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RET C634W	Thyroid Gland Medullary Carcinoma	RET C634W	Thyroid Gland Medullary Carcinoma	RAF265 Sensitive: D – Preclinical RAF265 Sensitive : D	RAF265 Sensitive: D – Preclinical RAF265 Sensitive : D
KRAS G12R	Thyroid Gland Medullary Carcinoma	KRAS G12R	Thyroid Gland Medullary Carcinoma	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D
BRAF mutation	Thyroid Gland Medullary Carcinoma	BRAF mutation	Thyroid Gland Medullary Carcinoma	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D
PTEN mutation	Thyroid Gland Medullary Carcinoma	PTEN mutation	Thyroid Gland Medullary Carcinoma	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D
RET mutation	Thyroid Gland Medullary Carcinoma	RET mutation	Thyroid Gland Medullary Carcinoma	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D
NRAS mutation	Thyroid Gland Medullary Carcinoma	NRAS mutation	Thyroid Gland Medullary Carcinoma	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D
KRAS mutation	Thyroid Gland Medullary Carcinoma	KRAS mutation	Thyroid Gland Medullary Carcinoma	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D	RTB101 + RAF265 Sensitive: D – Preclinical RTB101 + RAF265 Sensitive : D