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DRUG:

dovitinib (TKI258)

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News alerts, weekly reports and conference planners

Company:

Novartis, Oncoheroes

Drug class:

FGFR inhibitor, VEGFR inhibitor, PDGFR inhibitor, pan-TRK inhibitor

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FGFR1 amplification	Breast Cancer	FGFR1 amplification	Breast Cancer	TKI258 Sensitive: C2 – Inclusion Criteria TKI258 Sensitive : C2	TKI258 Sensitive: C2 – Inclusion Criteria TKI258 Sensitive : C2
FGF3 amplification	Breast Cancer	FGF3 amplification	Breast Cancer	TKI258 Sensitive: C3 – Early Trials TKI258 Sensitive : C3	TKI258 Sensitive: C3 – Early Trials TKI258 Sensitive : C3
FGFR2 amplification	Breast Cancer	FGFR2 amplification	Breast Cancer	TKI258 Sensitive: C3 – Early Trials TKI258 Sensitive : C3	TKI258 Sensitive: C3 – Early Trials TKI258 Sensitive : C3
FGFR1 amplification	Lung Non-Small Cell Squamous Cancer	FGFR1 amplification	Lung Non-Small Cell Squamous Cancer	TKI258 Sensitive: C3 – Early Trials TKI258 Sensitive : C3	TKI258 Sensitive: C3 – Early Trials TKI258 Sensitive : C3
FGFR2-CCDC6 fusion	Cholangiocarcinoma	FGFR2-CCDC6 fusion	Cholangiocarcinoma	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D
FGFR2 mutation	Endometrial Cancer	FGFR2 mutation	Endometrial Cancer	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D
FGFR1 overexpression	Bladder Cancer	FGFR1 overexpression	Bladder Cancer	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D
FLT3-ITD mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation	Acute Myelogenous Leukemia	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D
MPZL3 overexpression	Breast Cancer	MPZL3 overexpression	Breast Cancer	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D	TKI258 Sensitive: D – Preclinical TKI258 Sensitive : D