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    DRUG:

    PF-07257876

    i
    Other names: PF-07257876
    Associations

    News

    Trials
    Company:
    Pfizer
    Drug class:
    PD-L1 inhibitor, CD47 inhibitor
    Related drugs:
    Associations

    News

    Trials
    9ms
    Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors. (clinicaltrials.gov)
    P1, N=29, Completed, Pfizer | Active, not recruiting --> Completed
    Trial completion
    |
    PD-L1 (Programmed death ligand 1)
    |
    PF-07257876
    1year
    Addressing Domain Specificity in the Development of a Cell-Based Binding Assay for the Detection of Neutralizing Antibodies Against a CD47xPD-L1 Bispecific Antibody. (PubMed, AAPS J)
    PF-07257876 is a bispecific antibody being developed for the treatment of certain advanced or metastatic solid tumors...Specifically, mock samples containing a mixture of NAb positive controls against both binding domains of the bispecific antibody produced false-negative results in the cell-based binding assay. An adaptation made to the standard BEAD approach restored domain-specific NAb detection, while also contributing to an assay sensitivity of 1 µg/mL in the presence of a clinically relevant drug tolerance level of up to 400 µg/mL.
    Journal
    |
    PF-07257876
    over1year
    Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors. (clinicaltrials.gov)
    P1, N=28, Active, not recruiting, Pfizer | Recruiting --> Active, not recruiting | N=90 --> 28 | Trial completion date: Mar 2026 --> Oct 2023 | Trial primary completion date: Nov 2024 --> Oct 2023
    Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date • IO biomarker • Metastases
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    PF-07257876
    over1year
    Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors. (clinicaltrials.gov)
    P1, N=90, Recruiting, Pfizer | Trial primary completion date: Dec 2025 --> Nov 2024
    Trial primary completion date • IO biomarker • Metastases
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    PF-07257876
    2years
    Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors. (clinicaltrials.gov)
    P1, N=90, Recruiting, Pfizer | Trial completion date: Jul 2025 --> Dec 2025 | Trial primary completion date: Jul 2025 --> Dec 2025
    Trial completion date • Trial primary completion date • IO biomarker • Metastases
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    PF-07257876
    over2years
    Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors. (clinicaltrials.gov)
    P1, N=90, Recruiting, Pfizer | Trial completion date: Jul 2024 --> Jul 2025 | Trial primary completion date: Jul 2024 --> Jul 2025
    Trial completion date • Trial primary completion date • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    PF-07257876
    3years
    Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors. (clinicaltrials.gov)
    P1, N=90, Recruiting, Pfizer | Not yet recruiting --> Recruiting
    Clinical • Enrollment open • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    PF-07257876
    over3years
    Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors. (clinicaltrials.gov)
    P1, N=90, Not yet recruiting, Pfizer
    Clinical • New P1 trial • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    PF-07257876