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DRUG:

bintrafusp alfa (M7824)

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Company:

EMD Serono

Drug class:

PD-L1 inhibitor, TGFβ inhibitor

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PD-L1 overexpression	Non Small Cell Lung Cancer	PD-L1 overexpression	Non Small Cell Lung Cancer	M7824 Sensitive: B - Late Trials M7824 Sensitive : B	M7824 Sensitive: B - Late Trials M7824 Sensitive : B
TMB-H	Non Small Cell Lung Cancer	TMB-H	Non Small Cell Lung Cancer	M7824 Sensitive: B - Late Trials M7824 Sensitive : B	M7824 Sensitive: B - Late Trials M7824 Sensitive : B
PD-L1 expression	Biliary Tract Cancer	PD-L1 expression	Biliary Tract Cancer	M7824 Sensitive: C2 – Inclusion Criteria M7824 Sensitive : C2	M7824 Sensitive: C2 – Inclusion Criteria M7824 Sensitive : C2
MSI-H/dMMR	Solid Tumor	MSI-H/dMMR	Solid Tumor	M7824 Resistant: C3 – Early Trials M7824 Resistant : C3	M7824 Resistant: C3 – Early Trials M7824 Resistant : C3
TGFB1 elevation	Gastroesophageal Cancer	TGFB1 elevation	Gastroesophageal Cancer	M7824 Sensitive: C3 – Early Trials M7824 Sensitive : C3	M7824 Sensitive: C3 – Early Trials M7824 Sensitive : C3
TGFB1 elevation	Gastric Cancer	TGFB1 elevation	Gastric Cancer	M7824 Sensitive: C3 – Early Trials M7824 Sensitive : C3	M7824 Sensitive: C3 – Early Trials M7824 Sensitive : C3
IFNG expression	Colorectal Cancer	IFNG expression	Colorectal Cancer	M7824 Sensitive: C3 – Early Trials M7824 Sensitive : C3	M7824 Sensitive: C3 – Early Trials M7824 Sensitive : C3
IDH2 mutation	Glioblastoma	IDH2 mutation	Glioblastoma	M7824 Sensitive: C3 – Early Trials M7824 Sensitive : C3	M7824 Sensitive: C3 – Early Trials M7824 Sensitive : C3
KRAS mutation + PD-L1 expression	Colorectal Cancer	KRAS mutation + PD-L1 expression	Colorectal Cancer	M7824 Sensitive: C4 – Case Studies M7824 Sensitive : C4	M7824 Sensitive: C4 – Case Studies M7824 Sensitive : C4