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DRUG:

Cylembio (imsapepimut and etimupepimut, adjuvanted)

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Company:

IO Biotech

Drug class:

PD-L1 inhibitor, IDO inhibitor

Related drugs:

Dual TDO/IDO Inhibitor (0)

IDO/TDO dual inhibitor (0)

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durvalumab (200)

benmelstobart (12)

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envafolimab (6)

socazolimab (2)

atezolizumab and hyaluronidase-tqjs (1)

cosibelimab-ipdl (1)

adebrelimab (0)

CF33-hNIS-antiPDL1 (0)

PD-L1.t-haNK (0)

PF-07257876 (0)

Undisclosed anti-PD-L1 antibody (0)

Dual TDO/IDO Inhibitor (0)

IDO/TDO dual inhibitor (0)

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LDH elevation	Melanoma	LDH elevation	Melanoma	nivolumab + imsapepimut and etimupepimut, adjuvanted Sensitive: C3 – Early Trials nivolumab + imsapepimut and etimupepimut, adjuvanted Sensitive : C3	nivolumab + imsapepimut and etimupepimut, adjuvanted Sensitive: C3 – Early Trials nivolumab + imsapepimut and etimupepimut, adjuvanted Sensitive : C3
PD-L1 negative	Melanoma	PD-L1 negative	Melanoma	nivolumab + imsapepimut and etimupepimut, adjuvanted Sensitive: C3 – Early Trials nivolumab + imsapepimut and etimupepimut, adjuvanted Sensitive : C3	nivolumab + imsapepimut and etimupepimut, adjuvanted Sensitive: C3 – Early Trials nivolumab + imsapepimut and etimupepimut, adjuvanted Sensitive : C3
PD-L1 expression	Head and Neck Cancer	PD-L1 expression	Head and Neck Cancer	pembrolizumab + imsapepimut and etimupepimut, adjuvanted Sensitive: C3 – Early Trials pembrolizumab + imsapepimut and etimupepimut, adjuvanted Sensitive : C3	pembrolizumab + imsapepimut and etimupepimut, adjuvanted Sensitive: C3 – Early Trials pembrolizumab + imsapepimut and etimupepimut, adjuvanted Sensitive : C3
PD-L1 overexpression	Non Small Cell Lung Cancer	PD-L1 overexpression	Non Small Cell Lung Cancer	pembrolizumab + imsapepimut and etimupepimut, adjuvanted Sensitive: C3 – Early Trials pembrolizumab + imsapepimut and etimupepimut, adjuvanted Sensitive : C3	pembrolizumab + imsapepimut and etimupepimut, adjuvanted Sensitive: C3 – Early Trials pembrolizumab + imsapepimut and etimupepimut, adjuvanted Sensitive : C3