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DRUG:

magrolimab (GS-4721)

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Company:

Gilead, Ono Pharma

Drug class:

CD47 inhibitor

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No biomarker	Myelodysplastic Syndrome	No biomarker	Myelodysplastic Syndrome	GS-4721 Sensitive: B - Late Trials GS-4721 Sensitive : B	GS-4721 Sensitive: B - Late Trials GS-4721 Sensitive : B
No biomarker	Acute Myelogenous Leukemia	No biomarker	Acute Myelogenous Leukemia	GS-4721 Sensitive: B - Late Trials GS-4721 Sensitive : B	GS-4721 Sensitive: B - Late Trials GS-4721 Sensitive : B
TP53 mutation	Acute Myelogenous Leukemia	TP53 mutation	Acute Myelogenous Leukemia	GS-4721 Sensitive: C2 – Inclusion Criteria GS-4721 Sensitive : C2	GS-4721 Sensitive: C2 – Inclusion Criteria GS-4721 Sensitive : C2
TP53 mutation	Acute Myelogenous Leukemia	TP53 mutation	Acute Myelogenous Leukemia	venetoclax + GS-4721 Sensitive: C2 – Inclusion Criteria venetoclax + GS-4721 Sensitive : C2	venetoclax + GS-4721 Sensitive: C2 – Inclusion Criteria venetoclax + GS-4721 Sensitive : C2
TP53 mutation	Myelodysplastic Syndrome	TP53 mutation	Myelodysplastic Syndrome	GS-4721 Sensitive: C3 – Early Trials GS-4721 Sensitive : C3	GS-4721 Sensitive: C3 – Early Trials GS-4721 Sensitive : C3
TP53 wild-type	Myelodysplastic Syndrome	TP53 wild-type	Myelodysplastic Syndrome	GS-4721 Sensitive: C3 – Early Trials GS-4721 Sensitive : C3	GS-4721 Sensitive: C3 – Early Trials GS-4721 Sensitive : C3
PD-L1 expression	Urothelial Cancer	PD-L1 expression	Urothelial Cancer	atezolizumab + GS-4721 Sensitive: C3 – Early Trials atezolizumab + GS-4721 Sensitive : C3	atezolizumab + GS-4721 Sensitive: C3 – Early Trials atezolizumab + GS-4721 Sensitive : C3
HER-2 positive	HER2 Positive Breast Cancer	HER-2 positive	HER2 Positive Breast Cancer	trastuzumab + GS-4721 Sensitive: D – Preclinical trastuzumab + GS-4721 Sensitive : D	trastuzumab + GS-4721 Sensitive: D – Preclinical trastuzumab + GS-4721 Sensitive : D