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DRUG:

Ordspono (odronextamab)

i
Other names: REGN1979, REGN 1979, RGN1979, REGN-1979
Company:
Regeneron, ZAI Lab
Drug class:
CD20 inhibitor, CD3 agonist
Related drugs:
14d
Enrollment open
|
carboplatin • Rituxan (rituximab) • ifosfamide • etoposide IV • dexamethasone • Zynlonta (loncastuximab tesirine-lpyl) • Ordspono (odronextamab)
1m
The landscape of T-cell engagers for the treatment of follicular lymphoma. (PubMed, Oncoimmunology)
CD3 × CD20 BsAbs have shown the most promise in clinical development for B-NHL patients, with structural variations affecting their target affinity and potency. This review summarizes the current clinical trials of BsAbs for relapsed/refractory FL, highlighting the approval of some agents, their role in first-line treatment or combination therapies, their toxicity profiles, and the future of this therapeutic approach compared to other immune cell therapies.
Review • Journal
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CD20 (Membrane Spanning 4-Domains A1)
|
Epkinly (epcoritamab-bysp) • Lunsumio (mosunetuzumab-axgb) • Columvi (glofitamab-gxbm) • Ordspono (odronextamab)
3ms
Trial completion date • Trial primary completion date • Combination therapy
|
Rituxan (rituximab) • lenalidomide • Ordspono (odronextamab)
3ms
ELM-2: A Study to Assess the Anti-Tumor Activity and Safety of Odronextamab in Adult Patients With B-cell Non-Hodgkin Lymphoma Who Have Been Previously Treated With Other Cancer Therapies (clinicaltrials.gov)
P2, N=576, Recruiting, Regeneron Pharmaceuticals | Trial completion date: Feb 2028 --> Dec 2029 | Trial primary completion date: Dec 2025 --> Aug 2028
Trial completion date • Trial primary completion date
|
Ordspono (odronextamab)
3ms
Safety and efficacy of odronextamab in patients with relapsed or refractory follicular lymphoma. (PubMed, Ann Oncol)
Odronextamab achieved high complete response rates with generally manageable safety in patients with heavily pretreated R/R FL.
Journal
|
CD20 (Membrane Spanning 4-Domains A1)
|
Ordspono (odronextamab)
4ms
Glo-BNHL: A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
P2/3, N=210, Active, not recruiting, University of Birmingham | Not yet recruiting --> Active, not recruiting
Enrollment closed
|
carboplatin • Rituxan (rituximab) • ifosfamide • etoposide IV • dexamethasone • Zynlonta (loncastuximab tesirine-lpyl) • Ordspono (odronextamab)
4ms
The Evolving Role of Bispecific Antibodies in Diffuse Large B-Cell Lymphoma. (PubMed, J Pers Med)
Rituximab was the first one approved...Polatuzumab, a CD79b-targeting ADC, is approved as first-line treatment in high-risk patients in combination with chemo-immunotherapy...To date, two BsAbs (glofitamab and epcoritamab) are approved as monotherapy in third-line treatment in DLBCL. Combination strategies with chemotherapy, immunotherapy, and ADCs are currently under investigation with encouraging results in first-line or subsequent lines of treatment. In the following review, we focus on the structure of BsAbs, the mechanism of action, clinical efficacy, and the mechanisms of resistance to BsAbs.
Review • Journal
|
CD79B (CD79b Molecule)
|
Rituxan (rituximab) • Epkinly (epcoritamab-bysp) • Polivy (polatuzumab vedotin-piiq) • Columvi (glofitamab-gxbm) • Ordspono (odronextamab)
5ms
Trial completion date • Trial primary completion date
|
CD20 (Membrane Spanning 4-Domains A1)
|
Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Ordspono (odronextamab)
7ms
Glo-BNHL: A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
P2/3, N=210, Not yet recruiting, University of Birmingham | Trial completion date: Oct 2032 --> May 2033 | Initiation date: Oct 2023 --> May 2024 | Trial primary completion date: Oct 2030 --> May 2031
Trial completion date • Trial initiation date • Trial primary completion date
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carboplatin • Rituxan (rituximab) • ifosfamide • etoposide IV • dexamethasone • Zynlonta (loncastuximab tesirine-lpyl) • Ordspono (odronextamab)
8ms
Molecular assessment of intratumoral immune cell subsets and potential mechanisms of resistance to odronextamab, a CD20×CD3 bispecific antibody, in patients with relapsed/refractory B-cell non-Hodgkin lymphoma. (PubMed, J Immunother Cancer)
This biomarker analysis expands on clinical findings of odronextamab in patients with R/R B-NHL, providing verification of the suitability of CD20 as a therapeutic target, as well as evidence for potential mechanisms of action and resistance.
Journal • Immune cell
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PD-L1 (Programmed death ligand 1) • CD20 (Membrane Spanning 4-Domains A1) • CD8 (cluster of differentiation 8) • CD79B (CD79b Molecule) • CD22 (CD22 Molecule)
|
CD20 expression
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Ordspono (odronextamab)
8ms
Enrollment open
|
Libtayo (cemiplimab-rwlc) • Ordspono (odronextamab)
9ms
New P3 trial
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cisplatin • carboplatin • gemcitabine • Rituxan (rituximab) • cytarabine • ifosfamide • etoposide IV • Ordspono (odronextamab)
11ms
OLYMPIA-5: A Trial to Learn if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Participants With Follicular Lymphoma and Marginal Zone Lymphoma (clinicaltrials.gov)
P3, N=470, Recruiting, Regeneron Pharmaceuticals | Trial completion date: Jun 2029 --> Oct 2029 | Trial primary completion date: Jun 2029 --> Oct 2029
Trial completion date • Trial primary completion date • Combination therapy
|
Rituxan (rituximab) • lenalidomide • Ordspono (odronextamab)
12ms
A Systematic Literature Review (SLR) and Meta-Analysis of Clinical Evidence of Second Line or Later (2L+) Treatments for Follicular Lymphoma (FL) in Adult Patients (ASH 2023)
Eligible treatments included CAR T cell therapies (axicabtagene ciloleucel, lisocabtagene maraleucel, and tisagenlecleucel), T cell engagers (mosunetuzumab, glofitamab, epcoritamab, odronextamab), phosphatidylinositol 3-kinase (PI3K) inhibitors (copanlisib, duvelisib, idelalisib), HSCT, yttrium-90 (90Y) ibritumomab tiuxetan, tazemetostat, and conventional therapies (immunochemotherapies, single- or multiagent chemo- or immunotherapies, and alkylating agents). This SLR demonstrated an evolving FL treatment landscape, with new agents such as CAR T cell therapies and T cell engagers exhibiting potential for improving effectiveness of treatment for patients in 3L+, 4L+, and 2L+ POD24 populations.
Retrospective data • Review
|
Aliqopa (copanlisib) • Zydelig (idelalisib) • Copiktra (duvelisib) • Yescarta (axicabtagene ciloleucel) • Breyanzi (lisocabtagene maraleucel) • Tazverik (tazemetostat) • Kymriah (tisagenlecleucel-T) • Epkinly (epcoritamab-bysp) • Zevalin (ibritumomab tiuxetan) • Lunsumio (mosunetuzumab-axgb) • Columvi (glofitamab-gxbm) • Ordspono (odronextamab)
1year
Odronextamab Demonstrates Durable Complete Responses in Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Progressing after CAR-T Therapy: Outcomes from the ELM-1 Study (ASH 2023)
These data support the potential role of odronextamab in the treatment paradigm for R/R DLBCL. Further studies to evaluate the optimal sequencing and combinations of odronextamab with CAR-T therapy are warranted.
Clinical • IO biomarker
|
CD20 (Membrane Spanning 4-Domains A1)
|
Ordspono (odronextamab)
1year
P2 data • Minimal residual disease • Circulating tumor DNA
|
TP53 (Tumor protein P53) • CD20 (Membrane Spanning 4-Domains A1)
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TP53 mutation
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Ordspono (odronextamab)
1year
Odronextamab Monotherapy for the Treatment of Relapsed/Refractory (R/R) Follicular Lymphoma (FL) and Diffuse Large B-Cell Lymphoma (DLBCL): Focus on Clinical Pharmacology and Pharmacometrics in the ELM-1 and ELM-2 Studies (ASH 2023)
The studied regimens showed clinically meaningful activity and acceptable tolerability, and the risk of any Gr or Gr ≥3 TEAEs is not increased from low to high odronextamab exposures. Comprehensive PK, PD, exposure-efficacy, and exposure-safety analyses demonstrated that the selected odronextamab dose regimens have favorable efficacy and generally manageable safety profiles for the treatment of R/R FL and DLBCL.
Clinical
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CD20 (Membrane Spanning 4-Domains A1)
|
Ordspono (odronextamab)
1year
New P3 trial
|
CD20 (Membrane Spanning 4-Domains A1)
|
CD20 positive
|
Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Ordspono (odronextamab)
1year
New P3 trial • Combination therapy
|
CD20 (Membrane Spanning 4-Domains A1)
|
Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Ordspono (odronextamab)
1year
New P3 trial
|
CD20 (Membrane Spanning 4-Domains A1)
|
Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • bendamustine • Ordspono (odronextamab)
over1year
A Study to Learn How Safe and Tolerable Odronextamab and Cemiplimab Are in Adult Patients With B-cell Malignancies (clinicaltrials.gov)
P1, N=62, Active, not recruiting, Regeneron Pharmaceuticals | N=172 --> 62 | Trial completion date: Aug 2026 --> Dec 2026 | Trial primary completion date: Aug 2026 --> Dec 2026
Enrollment change • Trial completion date • Trial primary completion date
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Libtayo (cemiplimab-rwlc) • Ordspono (odronextamab)
over1year
ELM-1: Study to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell Malignancies (clinicaltrials.gov)
P1, N=200, Active, not recruiting, Regeneron Pharmaceuticals | Recruiting --> Active, not recruiting | N=298 --> 200
Enrollment closed • Enrollment change
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Ordspono (odronextamab)
over1year
Front Line Management of DLBCL – Can we Beat DLBCL? (ICLLM 2023)
Examples include the Phoenix study in which ibrutinib combined with R-CHOP was compared with R-CHOP in non-germinal centre derived DLBCL (defined by immunohistochemistry). The GOYA study investigated a more potent anti-CD20 antibody, obinutuzumab, combined with CHOP but again no benefit was seen compared with R-CHOP...The REMARC study was a phase 3 randomised, placebo-controlled trial in patients aged 60-80y who had achieved a PR or CR to 6-8 cycles of R-CHOP for DLBCL assessing 2 years of maintenance lenalidomide (Thieblemont et al, 2017)...Patients then received 5 cycles of R-CHOP or R-CHOP combined with bortezomib...This has led investigators to reason that if a better tolerated BTK were used and if primary prophylaxis with, for example, GCSF and co-trimoxazole were instituted for all patients, the benefit seen in younger patients could be seen for all...Furthermore there is a randomised phase III study (the Escalade trial) comparing R-CHOP with R-CHOP combined with acalabrutinib in patients 70y or younger. A very interesting novel group of molecules are the bispecific antibodies with a number in development in diffuse large B-cell lymphoma: glofitamab, epcoritamab and odronextamab...Whilst outcomes with R-miniCHOP are encouraging, more work clearly needs to be done in this patient group. One ongoing study to highlight is the POLAR BEAR trial which is a randomised studies comparing R-miniCHOP with R-miniCHP combined with polatuzumab vedotin in patients 80y or older or frail patients 75y or older.
IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • CD79B (CD79b Molecule)
|
Imbruvica (ibrutinib) • Rituxan (rituximab) • lenalidomide • bortezomib • Gazyva (obinutuzumab) • Calquence (acalabrutinib) • vincristine • Epkinly (epcoritamab-bysp) • Polivy (polatuzumab vedotin-piiq) • Columvi (glofitamab-gxbm) • Ordspono (odronextamab)
over1year
TRIAL IN PROGRESS: PHASE 1 TRIAL EVALUATING THE SAFETY AND TOLERABILITY OF ODRONEXTAMAB IN COMBINATION WITH CEMIPLIMAB IN RELAPSED/REFRACTORY AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMA (EHA 2023)
This Ph 1 trial is determining the tolerability and preliminary clinical efficacy of odronextamab plus cemiplimab to treat pts with R/R aggressive B-NHL.
Clinical • P1 data • Combination therapy
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BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6)
|
BCL6 translocation
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Libtayo (cemiplimab-rwlc) • Ordspono (odronextamab)
over1year
TRIAL IN PROGRESS: PHASE 3 TRIAL OF ODRONEXTAMAB PLUS LENALIDOMIDE VERSUS RITUXIMAB PLUS LENALIDOMIDE IN RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA AND MARGINAL ZONE LYMPHOMA (OLYMPIA-5) (EHA 2023)
This Phase 3 trial will determine the efficacy and safety of odronextamab plus lenalidomide compared with R2 in patients with R/R FL and MZL. Phase III, Bispecific, Non-Hodgkin's lymphoma, Follicular lymphoma
P3 data
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Rituxan (rituximab) • lenalidomide • Ordspono (odronextamab)
over1year
TRIAL IN PROGRESS: FOLLICULAR LYMPHOMA OUTCOMES IN RELAPSED/REFRACTORY PATIENTS TREATED WITH SYSTEMIC THERAPY IN A REAL- WORLD ASSESSMENT (FLORA) (EHA 2023)
The study population will be selected based on similar eligibility criteria as the FL Grade 1–3a arm of the odronextamab ELM-2 trial (NCT03888105; Figure)...When complete, FLORA will provide important current information on the RW outcomes of patients with FL and provide a valuable source of control data for comparative studies in R/R FL. Follicular lymphoma, Non-Hodgkin's lymphoma, Relapsed lymphoma, Real world data
Clinical • Real-world
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Ordspono (odronextamab)
over1year
TRIAL IN PROGRESS: PHASE 3 TRIAL EVALUATING THE EFFICACY AND SAFETY OF ODRONEXTAMAB VERSUS STANDARD OF CARE THERAPY IN RELAPSED/REFRACTORY AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMA (OLYMPIA-4) (EHA 2023)
OLYMPIA-4 will determine the utility of odronextamab monotherapy as a novel alternative treatment option for pts with aggressive R/R B-NHL who have relapsed early (within 1 year) and/or were refractory to first-line therapy.
Clinical • P3 data
|
Ordspono (odronextamab)
over1year
TRIAL IN PROGRESS: ATHENA-1 – A PHASE 1 STUDY TO ASSESS SAFETY AND TOLERABILITY OF REGN5837 IN COMBINATION WITH ODRONEXTAMAB IN PATIENTS WITH RELAPSED/REFRACTORY AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMA (EHA 2023)
This Phase 1, open-label, first-in-human study will assess the safety and tolerability of REGN5837 in combinationwith odronextamab in patients with R/R aggressive B-NHL.
Clinical • P1 data • Combination therapy
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CD22 (CD22 Molecule)
|
Ordspono (odronextamab) • REGN5837
over1year
TRIAL IN PROGRESS: PHASE 3 TRIAL EVALUATING THE EFFICACY AND SAFETY OF ODRONEXTAMAB PLUS CHEMOTHERAPY VERSUS RITUXIMAB PLUS CHEMOTHERAPY IN PREVIOUSLY UNTREATED FOLLICULAR LYMPHOMA (OLYMPIA- 2) (EHA 2023)
This Phase 3 trial will determine the utility of odronextamab plus chemotherapy (Odro-CHOP/Odro-CVP) compared with R-CHOP/R-CVP as a first-line treatment for patients with previously untreated FL. Follicular lymphoma, Non-Hodgkin's lymphoma, Phase III, Bispecific
Clinical • P3 data
|
CD20 (Membrane Spanning 4-Domains A1)
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CD20 positive
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Rituxan (rituximab) • Ordspono (odronextamab)
over1year
TRIAL IN PROGRESS: ODRONEXTAMAB, A CD20×CD3 BISPECIFIC ANTIBODY, FOR THE TREATMENT OF PATIENTS WITH RELAPSED/REFRACTORY MARGINAL ZONE LYMPHOMA (MZL) – A COHORT FROM THE ELM-2 STUDY (EHA 2023)
Options after progression on rituximab-based regimens include the Bruton's tyrosine kinase inhibitor ibrutinib, which demonstrated an ORR of 46%, but a complete response (CR) rate of only 3%, in its pivotal trial in R/R MZL. The ELM-2 study will assess the activity of odronextamab monotherapy across different subtypes of R/R B-NHL, including in patients with R/R MZL who are in need of new, effective therapies. Relapsed lymphoma, Bispecific, Non-Hodgkin's lymphoma, Marginal zone
Clinical
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CD20 (Membrane Spanning 4-Domains A1)
|
CD20 expression
|
Imbruvica (ibrutinib) • Rituxan (rituximab) • Ordspono (odronextamab)
over1year
TRIAL IN PROGRESS: PHASE 3 TRIAL EVALUATING THE EFFICACY AND SAFETY OF ODRONEXTAMAB VERSUS INVESTIGATOR'S CHOICE IN PREVIOUSLY UNTREATED FOLLICULAR LYMPHOMA (OLYMPIA-1) (EHA 2023)
OLYMPIA-1 is a Phase 3, open-label, randomized, multicenter trial of odronextamab versus CIT (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone [R-CHOP]; rituximab, cyclophosphamide, vincristine, prednisone [R-CVP]; or rituximab-bendamustine) in previously untreated FL. This Phase 3 trial will determine the utility of odronextamab monotherapy compared with CIT as a first-line treatment for patients with previously untreated FL. Non-Hodgkin's lymphoma, Follicular lymphoma, Bispecific, Phase III
Clinical • P3 data
|
CD20 (Membrane Spanning 4-Domains A1)
|
CD20 positive
|
Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • bendamustine • Ordspono (odronextamab)
over1year
TRIAL IN PROGRESS: PHASE 3 TRIAL EVALUATING THE EFFICACY AND SAFETY OF ODRONEXTAMAB PLUS CHOP (O-CHOP) VERSUS R-CHOP IN PREVIOUSLY UNTREATED DIFFUSE LARGE B-CELL LYMPHOMA (OLYMPIA-3) (EHA 2023)
Background: While the first-line combination of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R- CHOP) has improved outcomes for diffuse large B-cell lymphoma (DLBCL), up to 40% of patients will experience relapsed/refractory (R/R) disease (Sehn & Salles. OLYMPIA-3 will determine the tolerability and clinical efficacy of O-CHOP versus R-CHOP as first-line treatment inpatients that have IPI intermediate- to high-risk DLBCL. Monoclonal antibody, Diffuse large B cell lymphoma, Bispecific, Non-Hodgkin's lymphoma
Clinical • P3 data
|
CD20 (Membrane Spanning 4-Domains A1)
|
CD20 positive
|
Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Ordspono (odronextamab)
over1year
TRIAL IN PROGRESS: OUTCOMES IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA TREATED WITH SYSTEMIC THERAPY FROM REAL-WORLD EXPERIENCE (ORCHID) (EHA 2023)
The study population will be selected based on similar eligibility criteria as the R/R DLBCL arm of the odronextamab ELM-2 trial (NCT03888105; Figure)...When complete, ORCHID will provide important current information on the RW outcomes of patients with DLBCL and provide a valuable source of control data for comparative studies in R/R DLBCL. Non-Hodgkin's lymphoma, Relapsed lymphoma, Diffuse large B cell lymphoma, Real world data
Clinical • Real-world evidence • Real-world
|
Ordspono (odronextamab)
over1year
LONG TERM FOLLOW-UP OF UNTREATED/RELAPSING MCL PATIENTS WITH THE IBRUTINIB, OBINUTUZUMAB, AND VENETOCLAX COMBINATION. (EHA 2023)
Patients who progressed were treated with Bendamustine-containing regimen (6 out of 10) and one patient received Odronextamab and anti-CD22xCD3 bispecific antibodies...Two patients prematurely discontinued the treatment, one patient had a PD at C4 and has subsequently been treated with R-CHOP, one patient relapsed after treatment completion and has been treated with Glofitamab... The Ibrutinib-Venetoclax-Obinutuzumab triplet is associated with a sustained disease control, in both R/R (4-y PFS of 50%) and newly diagnosed (4y-PFS of 80%) patients presenting with high risk-profiles (no low-MIPI patients were included in the Oasis Trial). The anti-CD20+Ibrutinib vs anti-CD20+Ibrutinib+Venetoclax combinations are currently under investigation in OASIS-II trial (NCT04802590) for untreated patients with MCL. Venetoclax, ibrutinib, Targeted therapy, Mantle cell lymphoma
Clinical
|
TP53 (Tumor protein P53)
|
TP53 mutation
|
Venclexta (venetoclax) • Imbruvica (ibrutinib) • Rituxan (rituximab) • Gazyva (obinutuzumab) • bendamustine • Columvi (glofitamab-gxbm) • Ordspono (odronextamab)
over1year
ODRONEXTAMAB IN PATIENTS WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA GRADE 1–3A: RESULTS FROM A PRESPECIFIED ANALYSIS OF THE PIVOTAL PHASE 2 STUDY ELM-2 (EHA 2023)
With the 0.7/4/20 step-up regimen (n=63), Gr 3 CRS was observed in 1 (2%) pt (no Gr 4 or 5 CRS), and all CRS events resolved; 19% of pts received tocilizumab for CRS management. In the ELM-2 study, odronextamab demonstrated compelling efficacy in pts with R/R FL, with 75% of pts achievingCR. Responses were durable, and survival outcomes favorable, in the context of heavily pretreated R/R FL. Odronextamab showed an acceptable safety profile; results with the 0.7/4/20 step-up regimen compared favorably to other CD20×CD3 bispecific antibodies, with only 1 case of Gr ≥3 CRS.
Clinical • P2 data
|
Actemra IV (tocilizumab) • Ordspono (odronextamab)
over1year
ODRONEXTAMAB IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA: RESULTS FROM A PRESPECIFIED ANALYSIS OF THE PIVOTAL PHASE 2 STUDY ELM-2 (EHA 2023)
In the ELM-2 trial, odronextamab showed clinically meaningful efficacy, durable CRs, and a manageable safety profile. These data confirm odronextamab efficacy in hard-to-treat, highly aggressive R/R DLBCL. The 0.7/4/20 odronextamab step-up regimen mitigates the risk of high-grade CRS, which is consistently observed with other bispecifics and CAR T therapies, and may present an important future option for the management of R/R DLBCL.
Clinical • P2 data
|
Ordspono (odronextamab)
over1year
SAFETY AND EFFICACY OF ANTICD20-CD3 BISPECIFIC T-CELL ENGAGING ANTIBODIES IN THE MANAGEMENT OF RELAPSED/REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA: A SYSTEMATIC REVIEW OF CLINICAL TRIALS (EHA 2023)
In the trials, mosunetuzumab, glofitamab, epcoritamab, odronextamab, IGM-2323, and plamotamab were identified as antiCD20-CD3 bsAbs, which are evaluated against RRDLBCL as monotherapy and in combination regimens (Table). Based on our analysis , antiCD20-CD3 bsAbs are safe and efficacious. Among these drugs, glofitamab, epcoritamab and odronextamab as monotherapy and/or in combination regimens are the most effective therapies against RRDLBCL. Drug (s) **Author Efficac y ORR, CR per Lugano/RR C for ML criteria **CRS Overall/G 3 per ASTCT/ Lee et al criteria Overall Toxicity G≥3 per CTCAE CNS Toxicity G≥3 Per CTCAE aNHL 35%Mosun IV Budde et al.
Clinical • Review
|
Epkinly (epcoritamab-bysp) • Lunsumio (mosunetuzumab-axgb) • imvotamab (IGM-2323) • Columvi (glofitamab-gxbm) • Ordspono (odronextamab) • plamotamab (XmAb13676)
almost2years
Optimization of Intravenous Odronextamab Step-up Regimen for Reducing the Risk of High-Grade Cytokine Release Syndrome (ASH 2022)
Background Odronextamab is a hinge-stabilized, human CD20×CD3 IgG4-based bispecific antibody that binds CD20-expressing cells and CD3 on T cells, targeting CD20+ cells via T-cell-mediated cytotoxicity, independent of T-cell receptor-mediated recognition. This indicates that the same therapeutic levels are achieved with both regimens, which is beneficial for the treatment of disease.Conclusion This optimized odronextamab dosing regimen was associated with lower risk of CRS and lower levels of baseline cytokine levels compared with the original regimen. The drug exposure was lower in the first cycle when the risk of CRS is greater, but it was comparable to that of the original regimen after the full dose of treatment was received, ensuring that odronextamab dose levels required for efficacy are maintained.
IL6 (Interleukin 6)
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CD20 expression
|
Ordspono (odronextamab) • T-cell receptor therapy