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DRUG:

NILK-2501

i
Other names: NILK-2501, NI-2501, NI 2501, NILK 2501
Associations
Trials
Company:
LamKap Bio, Light Chain Biosci
Drug class:
CD3 agonist, GPC-3 inhibitor
Related drugs:
Associations
Trials
almost2years
Novel GPC3xCD3 (NILK-2501) and GPC3xCD28 (NILK-3801) κλ Bispecific Antibodies for Next Generation Immunotherapy of GPC3-Expressing Solid Cancers (APASL 2023)
The superagonistic monoclonal anti-human CD28 antibody (IgG4κ) TGN1412 was used as comparator. Activity is maintained while it allows well tailorable dose response with reduced cytokine release. Compounds are currently in extensive pre-clinical assessment 999
IO biomarker
|
CD8 (cluster of differentiation 8) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CD4 (CD4 Molecule) • GPC3 (Glypican 3)
|
GPC3 expression • GPC3 positive
|
NILK-2501 • NILK-3801 • theralizumab (TAB08)