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    DRUG:

    JNJ-5322

    i
    Other names: JNJ-5322, JNJ-79635322, JNJ5322, JNJ79635322, JNJ 5322, JNJ 79635322
    Company:
    J&J
    Drug class:
    CD3 agonist, BCMA inhibitor, GPRC5D inhibitor
    Related drugs:
    3ms
    A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis (clinicaltrials.gov)
    P1, N=180, Recruiting, Janssen Research & Development, LLC | Trial completion date: Apr 2026 --> Apr 2027
    Trial completion date • Trispecific
    |
    JNJ-5322
    10ms
    A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis (clinicaltrials.gov)
    P1, N=170, Recruiting, Janssen Research & Development, LLC | Trial completion date: May 2025 --> Apr 2026
    Trial completion date • Trispecific
    |
    JNJ-5322
    1year
    Characterization of JNJ-79635322, a Novel BCMAxGPRC5DxCD3 T-Cell Redirecting Trispecific Antibody, for the Treatment of Multiple Myeloma (ASH 2023)
    JNJ-79635322 is a potential first-in-class trispecific antibody targeting BCMA and GPRC5D with the ability to deplete dual and single target expressing MM clones in preclinical studies vitro and in vivo. A Phase 1 dose-escalating study of JNJ-79635322 in myeloma patients is ongoing (NCT05652335).
    Trispecific
    |
    GPRC5D (G Protein-Coupled Receptor Class C Group 5 Member D)
    |
    GPRC5D expression
    |
    JNJ-5322
    1year
    A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov)
    P1, N=169, Recruiting, Janssen Research & Development, LLC | N=90 --> 169
    Enrollment change • Trispecific
    |
    JNJ-5322