JNJ-78306358 showed pharmacodynamic effects with induction of cytokines and T cell activation. JNJ-78306358 was associated with CRS-related toxicities including increased transaminases and pneumonitis which limited its dose escalation to potentially efficacious levels. Trial registration number ClinicalTrials.gov (No. NCT04991740).
4 months ago
Journal • Metastases
|
HLA-G (Major Histocompatibility Complex, Class I, G)
CRS was G1 or G2 and responded to tocilizumab. Considering the CRS-related toxicities and the ADA formation, the Sponsor decided to halt dose escalation. No recommended phase 2 dose was determined.
over 1 year ago
Clinical • Metastases
|
HLA-G (Major Histocompatibility Complex, Class I, G)