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DRUG:

JNJ-8902

i
Other names: JNJ-8902, JNJ-70218902, JNJ-902
Associations
Trials
Company:
Genmab, J&J
Drug class:
CD3 agonist, TMEFF2 inhibitor
Related drugs:
Associations
Trials
21d
A Study of JNJ-70218902 in Participants With Advanced Stage Solid Tumors (clinicaltrials.gov)
P1, N=82, Active, not recruiting, Janssen Research & Development, LLC | Trial completion date: Dec 2024 --> Jun 2025
Trial completion date
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JNJ-8902
1year
A Study of JNJ-70218902 in Participants With Advanced Stage Solid Tumors (clinicaltrials.gov)
P1, N=82, Active, not recruiting, Janssen Research & Development, LLC | Trial primary completion date: Sep 2023 --> Dec 2024
Trial primary completion date • Metastases
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JNJ-8902
over1year
A Study of JNJ-70218902 in Participants With Advanced Stage Solid Tumors (clinicaltrials.gov)
P1, N=82, Active, not recruiting, Janssen Research & Development, LLC | Trial completion date: Jun 2023 --> Sep 2023
Trial completion date • Metastases
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JNJ-8902
2years
Pharmacodynamics of JNJ-70218902, a TMEFF2 × CD3 bispecific antibody, in cynomolgus monkey (SITC 2022)
Ethics Approval The procedures involving the care and use of animals in this study were reviewed and approved by CR-MWN Institutional Animal Care and Use Committee before conduct (Testing Facility Study Number 886-526). During the study, the care and use of animals were conducted with guidance from the guidelines of the USA National Research Council.
PK/PD data • Preclinical • IO biomarker
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CD8 (cluster of differentiation 8) • IL2RA (Interleukin 2 receptor, alpha) • CD4 (CD4 Molecule) • CD69 (CD69 Molecule) • EGF (Epidermal growth factor) • GZMB (Granzyme B) • FOXP3 (Forkhead Box P3) • TMEFF2 (Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2)
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JNJ-8902
over2years
JNJ-70218902 (JNJ-902), a TMEFF2 x CD3 bispecific antibody, in prostate cancer: Initial results from a phase I dose escalation study (ESMO 2022)
Part 1 (dose escalation) is ongoing and Part 2 (dose expansion) of study will initiate once part 2 expansion dose is declared. Selection of part 2 expansion dosage is currently being adjusted and dose information will be presented.
P1 data
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TMEFF2 (Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2)
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AR expression
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JNJ-8902
over2years
Characterization of JNJ-70218902, a TMEFF2 x CD3 bispecific antibody, in prostate cancer models (AACR 2022)
Targeting TMEFF2 with the TMEFF2 × CD3 bispecific antibody JNJ-902 elicited robust T cell-mediated responses in both prostate cancer cells and xenograft models. Based on these data, a phase 1 dose escalation trial of JNJ-902 in patients with mCRPC is currently ongoing (NCT04397276).
Preclinical • Late-breaking abstract
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • IL2RA (Interleukin 2 receptor, alpha) • IL10 (Interleukin 10) • CASP3 (Caspase 3) • EGF (Epidermal growth factor) • GZMB (Granzyme B) • TMEFF2 (Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2)
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CD8 expression • IL2RA expression
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JNJ-8902