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DRUG:

JNJ-63709178

i
Other names: JNJ-63709178, CD123 x CD3 DuoBody, JNJ 63709178, CD123-CD3 DuoBody protein, CNTO 9958, JNJ-9178
Associations
Company:
Genmab, J&J
Drug class:
CD3 agonist, CD123 inhibitor
Related drugs:
Associations
over1year
First-in-Human Study of JNJ-63709178, a CD123/CD3 Targeting Antibody, in Relapsed/Refractory Acute Myeloid Leukemia. (PubMed, Clin Transl Sci)
Minimal clinical activity was observed across all cohorts. IV and SC dosing of JNJ-63709178 was associated with suboptimal drug exposure, unfavorable safety profiles, limited clinical activity, and inability to identify a recommended Phase 2 dose.
P1 data • Journal
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CD123 (Interleukin 3 Receptor Subunit Alpha)
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JNJ-63709178
3years
Dose Escalation Study of JNJ-63709178, a Humanized CD123 x CD3 DuoBody in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) (clinicaltrials.gov)
P1, N=62, Completed, Janssen Research & Development, LLC | Recruiting --> Completed | N=120 --> 62 | Trial completion date: Oct 2022 --> Mar 2021 | Trial primary completion date: May 2022 --> Mar 2021
Clinical • Trial completion • Enrollment change • Trial completion date • Trial primary completion date
|
CD123 (Interleukin 3 Receptor Subunit Alpha)
|
JNJ-63709178
almost4years
Dose Escalation Study of JNJ-63709178, a Humanized CD123 x CD3 DuoBody in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) (clinicaltrials.gov)
P1, N=120, Recruiting, Janssen Research & Development, LLC | Trial primary completion date: Oct 2020 --> May 2022
Clinical • Trial primary completion date
|
CD123 (Interleukin 3 Receptor Subunit Alpha)
|
JNJ-63709178
almost5years
Clinical • Trial completion date
|
CD123 (Interleukin 3 Receptor Subunit Alpha)
|
JNJ-63709178
almost5years
Dose Escalation Study of JNJ-63709178, a Humanized CD123 x CD3 DuoBody in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) (clinicaltrials.gov)
P1, N=120, Recruiting, Janssen Research & Development, LLC | N=60 --> 120 | Trial completion date: Oct 2021 --> May 2022
Clinical • Enrollment change • Trial completion date
|
CD123 (Interleukin 3 Receptor Subunit Alpha)
|
JNJ-63709178
almost6years
Dose Escalation Study of JNJ-63709178, a Humanized CD123 x CD3 DuoBody in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) (clinicaltrials.gov)
P1, N=60, Recruiting, Janssen Research & Development, LLC | Trial completion date: Apr 2021 --> Aug 2021 | Suspended --> Recruiting
Clinical • Enrollment open • Trial completion date
|
CD123 (Interleukin 3 Receptor Subunit Alpha)
|
JNJ-63709178
over6years
Trial completion date
|
CD123 (Interleukin 3 Receptor Subunit Alpha)
|
CD123 expression
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JNJ-63709178