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YH42946
i
Other names: YH42946, JIN-A04, YH-42946, YH 42946, JIN A04
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Company:
J Ints Bio, Yuhan Corp
Drug class:
HER2 inhibitor, HER2 exon 20 mutation inhibitor
Related drugs:
4d
A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate Safety, Tolerability, PK and Anti-tumor Activity of YH42946 (clinicaltrials.gov)
P1/2, N=161, Recruiting, Yuhan Corporation | Not yet recruiting --> Recruiting
Enrollment open
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YH42946
2ms
A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate Safety, Tolerability, PK and Anti-tumor Activity of YH42946 (clinicaltrials.gov)
P1/2, N=161, Recruiting, Yuhan Corporation
New P1/2 trial • EGFR exon 20 • Metastases
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YH42946
over1year
JIN-A04, highly effective tyrosine kinase inhibitor targeting HER2 exon 20 insertion mutations in NSCLC (AACR 2023)
It was superior to Mobocertinib (IC50 = 27.1 nM for YVMA and IC50 = 3.3 nM for GSP) and comparable with Poziotinib (IC50 = 3.4 nM for YVMA and IC50 = 0.4 nM for GSP). JIN-A04 is highly potent against HER2 exon 20 insertion mutations including YVMA and GSP, while largely sparing HER2 WT activity. Also, JIN-A04 demonstrated effective HER2 pathway inhibition. Based on these robust activities for HER2 exon 20 insertion, JIN-A04 is expected to provide a potent therapeutic opportunity for NSCLC patients with HER2 exon20 insertion mutations.
HER2 exon 20
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HER-2 (Human epidermal growth factor receptor 2)
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EGFR mutation • HER-2 mutation • HER-2 expression • HER-2 exon 20 insertion • HER-2 A775_G776insYVMA • HER-2 exon 20 mutation • HER-2 A775 • HER-2 P780-Y781insGSP • HER-2 YVMA • HER-2 exon 23 mutation
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Pozenveo (poziotinib) • Exkivity (mobocertinib) • YH42946
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