He subsequently developed liver metastases and was treated with FOLFIRI plus panitumumab...The regimen was switched to FOLFIRI plus bevacizumab, which achieved marked regression of all metastatic lesions...In colorectal cancer, repeat genetic testing of metastatic lesions should be considered, particularly in cases of treatment resistance. Molecular reassessment may reveal actionable alterations that guide therapy selection and optimize patient management.

19 hours ago

Journal

KRAS (KRAS proto-oncogene GTPase)

KRAS mutation • RAS mutation • RAS wild-type

Avastin (bevacizumab) • 5-fluorouracil • Vectibix (panitumumab) • irinotecan • leucovorin calcium

19h

Chemotherapy-induced cell cycle arrest is associated with increased claudin-18 isoform 2 expression and enhanced zolbetuximab-mediated cytotoxicity in gastric cancer. (PubMed, J Gastroenterol)

These results suggest that chemotherapeutic agents upregulate CLDN18.2 in GC cells at least in part through cell cycle arrest, and support combining zolbetuximab with chemotherapy and/or CDK inhibitors for GC treatment.

19 hours ago

Journal

CLDN18 (Claudin 18) • CDK1 (Cyclin-dependent kinase 1)

CLDN18.2 expression

cisplatin • paclitaxel • 5-fluorouracil • irinotecan • Vyloy (zolbetuximab-clzb)

PREOPANC-3: Perioperative or Adjuvant mFOLFIRINOX for Resectable Pancreatic Cancer (clinicaltrials.gov)

P3, N=378, Active, not recruiting, Erasmus Medical Center | Recruiting --> Active, not recruiting | Trial primary completion date: Feb 2026 --> Jan 2027

3 days ago

Enrollment closed • Trial primary completion date

5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium

A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies (clinicaltrials.gov)

P2, N=170, Recruiting, Mirati Therapeutics Inc. | Not yet recruiting --> Recruiting

3 days ago

Enrollment open

Keytruda (pembrolizumab) • Erbitux (cetuximab) • docetaxel • 5-fluorouracil • pemetrexed • oxaliplatin • irinotecan • Krazati (adagrasib) • leucovorin calcium

A Study of HX008 Compared to Chemotherapy in the First-Line Treatment of Subjects With MSI-H/dMMR Metastatic Colorectal Cancer (clinicaltrials.gov)

P3, N=190, Active, not recruiting, Taizhou Hanzhong biomedical co. LTD | Recruiting --> Active, not recruiting

4 days ago

Enrollment closed • Mismatch repair • MSI-H • dMMR

MSI (Microsatellite instability)

MSI-H/dMMR

Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • capecitabine • oxaliplatin • irinotecan • Puyouheng (pucotenlimab)

Clinical Trial of Lurbinectedin as Single-agent or in Combination With Irinotecan Versus Topotecan or Irinotecan in Patients With Relapsed Small-cell Lung Cancer (LAGOON) (clinicaltrials.gov)

P3, N=705, Completed, PharmaMar | Active, not recruiting --> Completed

5 days ago

Trial completion

irinotecan • topotecan • Zepzelca (lurbinectedin)

A Multicenter, Phase 3 Study of IBI343 Monotherapy Versus Treatment of Investigator's Choice in Subjects With Previously Treated, Claudin (CLDN) 18.2-positive, HER2-negative, Gastric or Gastroesophageal Junction Adenocarcinoma (G-HOPE-001) (clinicaltrials.gov)

P3, N=464, Active, not recruiting, Innovent Biologics (Suzhou) Co. Ltd. | Recruiting --> Active, not recruiting

5 days ago

Enrollment closed

CLDN18 (Claudin 18)

CLDN18.2 positive

paclitaxel • irinotecan • Lonsurf (trifluridine/tipiracil) • arcotatug tavatecan (TAK-921)

PHITT: Paediatric Hepatic International Tumour Trial (clinicaltrials.gov)

P3, N=450, Active, not recruiting, University of Birmingham | Trial completion date: Aug 2027 --> Dec 2027 | Trial primary completion date: Aug 2026 --> Dec 2026

5 days ago

Trial completion date • Trial primary completion date

cisplatin • carboplatin • gemcitabine • sorafenib • doxorubicin hydrochloride • oxaliplatin • etoposide IV • irinotecan • vincristine

14395: PREOPANC-6 study: dendritic cell immunotherapy after FOLFIRINOX chemotherapy in patients with resectable pancreatic cancer (2025-523134-28-00)

P2/3, N=143, Not yet recruiting, Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

5 days ago

New P2/3 trial

5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium • MesoPher (autologous dendritic cell vaccine)

Safety and Efficacy of FOLFIRI-3 (Split-Dose Irinotecan) for Unresectable Colorectal Cancer: A Stratified Analysis Based on UGT1A1 Gene Polymorphisms. (PubMed, Cancers (Basel))

For high-risk HCH patients, our findings regarding the tolerability of FOLFIRI-3 are strictly preliminary due to the small sample size and require further validation in larger, multi-institutional cohorts. Despite this limitation, this regimen serves as a valuable alternative for high-risk patients and provides superior survival benefits for single heterozygotes, likely due to optimized pharmacokinetics.

6 days ago

Journal

UGT1A1 (UDP glucuronosyltransferase family 1 member A1)

5-fluorouracil • irinotecan • leucovorin calcium

A Clinical Study of Iparomlimab and Tuvonralimab Combined With Bevacizumab and Alternating Triweekly CAPOX/mCAPIRI Regimen as First-line Treatment for Unresectable Advanced Colorectal Cancer (clinicaltrials.gov)

P2, N=70, Not yet recruiting, Jiangsu Cancer Institute & Hospital | Initiation date: Feb 2026 --> May 2026

6 days ago

Trial initiation date

MSI (Microsatellite instability)

Avastin (bevacizumab) • capecitabine • oxaliplatin • irinotecan • Qibeian (iparomlimab/tuvonralimab)

BEACON: Activity Study of Bevacizumab With Temozolomide ± Irinotecan for Neuroblastoma in Children (clinicaltrials.gov)

P2, N=225, Completed, University of Birmingham | Active, not recruiting --> Completed

6 days ago

Trial completion

Avastin (bevacizumab) • temozolomide • cyclophosphamide • irinotecan • topotecan • Qarziba (dinutuximab beta)