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    DRUG:

    irinotecan

    i
    Other names: CPT-11, CPT 11, DQ 2805, IHL-305, SN 38B11, U 101440E
    Company:
    Generic mfg.
    Drug class:
    Topoisomerase I inhibitor
    Related drugs:
    1d
    Phase III Study to Compare GFH375 and Chemotherapy in Patients With KRAS G12D-Mutant Metastatic Pancreatic Cancer (clinicaltrials.gov)
    P3, N=320, Not yet recruiting, Genfleet Therapeutics (Shanghai) Inc.
    New P3 trial
    |
    KRAS (KRAS proto-oncogene GTPase)
    |
    gemcitabine • paclitaxel • 5-fluorouracil • irinotecan • leucovorin calcium • Teysuno (gimeracil/oteracil/tegafur)
    1d
    NCI 10211: A Phase II, Single-Arm Study of Berzosertib in Combination with Irinotecan in Patients with Advanced TP53 Mutant Gastroesophageal Cancer. (PubMed, Oncologist)
    This novel combination of ATR inhibitor berzosertib with irinotecan did not lead to objective responses in patients with TP53-mutated, advanced gastroesophageal adenocarcinoma. The combination regimen was well tolerated without unexpected adverse events. This trial was registered with ClinicalTrials.gov (NCT03641313).
    P2 data • Journal
    |
    TP53 (Tumor protein P53)
    |
    TP53 mutation
    |
    irinotecan • berzosertib (M6620)
    2d
    SHOOL: Short Course or Long Course Radiotherapy as Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer (clinicaltrials.gov)
    P=N/A, N=150, Not yet recruiting, Rajiv Gandhi Cancer Institute & Research Center, India
    New trial
    |
    capecitabine • oxaliplatin • irinotecan
    2d
    Safety and Efficacy of Radiotherapy Combined With Immunochemotherapy in Pre-treated SCLC Patients With Liver Metastases (clinicaltrials.gov)
    P2, N=30, Not yet recruiting, Sichuan University
    New P2 trial
    |
    albumin-bound paclitaxel • etoposide IV • irinotecan • Zepzelca (lurbinectedin)
    2d
    Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body (clinicaltrials.gov)
    P2/3, N=437, Active, not recruiting, Children's Oncology Group | Recruiting --> Active, not recruiting | Initiation date: Jul 2026 --> Nov 2025
    Enrollment closed • Trial initiation date
    |
    doxorubicin hydrochloride • cyclophosphamide • Stivarga (regorafenib) • ifosfamide • etoposide IV • irinotecan • vincristine
    3d
    A Clinical Trial Testing the Safety of BNT327 (an Investigational Drug) and How Well it Works When Combined With Chemotherapy for People Who Have Not Been Treated Yet for Pancreatic Cancer (clinicaltrials.gov)
    P2, N=105, Not yet recruiting, BioNTech SE
    New P2 trial
    |
    gemcitabine • albumin-bound paclitaxel • irinotecan • pumitamig (BNT327)
    4d
    Impact of sex on efficacy and safety of 1st-line treatment with FOLFIRI plus cetuximab or bevacizumab in RAS/BRAF wildtype metastatic colorectal cancer - A subgroup analysis of the FIRE-3 (AIO KRK-0306) trial. (PubMed, Eur J Cancer)
    The exploratory analysis of FIRE-3 suggests that the efficacy of cetuximab combined with FOLFIRI in RAS wild-type mCRC is related to sex and primary tumor sidedness. The results support the inclusion of patient sex into the design of future trials.
    Journal
    |
    BRAF (B-raf proto-oncogene) • RAS (Rat Sarcoma Virus)
    |
    BRAF wild-type • RAS wild-type
    |
    Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • irinotecan • leucovorin calcium
    5d
    Inhibition of Small-cell Lung Cancer Angiogenesis by Irinotecan Metronomic Chemotherapy and Irinotecan Plus Everolimus. (PubMed, Anticancer Res)
    Daily administration of CPT-11 may have significant antitumor effects based on its anti-angiogenic effects. Daily administration of CPT-11 may be a novel second-line option for SCLC.
    Journal
    |
    PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)
    |
    everolimus • irinotecan
    6d
    Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Pancreatic Cancer (clinicaltrials.gov)
    P1, N=10, Not yet recruiting, Northwell Health
    New P1 trial
    |
    paclitaxel • doxorubicin hydrochloride • oxaliplatin • irinotecan
    6d
    REACtiVe-2: phase I evaluation of dendritic cell vaccination and agonistic CD40 therapy following (m)FOLFIRINOX in metastatic pancreatic cancer. (PubMed, Nat Commun)
    In conclusion, MesoPher/mitazalimab combination therapy is safe and tolerable in patients with metastatic PDAC and enhances systemic immune activation and local immune responses. Future research should evaluate the efficacy of this promising approach as maintenance therapy shortly after completing chemotherapy.
    P1 data • Journal
    |
    CD40 (CD40 Molecule)
    |
    5-fluorouracil • irinotecan • leucovorin calcium • MesoPher (autologous dendritic cell vaccine) • mitazalimab (ADC-1013)
    6d
    GRACIE: Testing Ivonescimab in Combination With Chemotherapy in Advanced or Metastatic Gastric/Gastroesophageal Adenocarcinoma (clinicaltrials.gov)
    P2, N=88, Recruiting, UNICANCER | Not yet recruiting --> Recruiting
    Enrollment open
    |
    paclitaxel • 5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium • Yidafan (ivonescimab)
    7d
    Perfluorooctanoic acid and perfluorooctanesulfonic acid induce resistance to chemotherapy in colorectal cancer. (PubMed, J Hazard Mater)
    The results indicated that PFOA and PFOS significantly increased the resistance of HCT116 and SW620 cells to Oxaliplatin (OXA), 5-Fluorouracil (5-FU), and Irinotecan (CPT-11). Further studies revealed that PFOA and PFOS reverse the cell cycle arrest effect of chemotherapeutic drugs on CRC cells by regulating the expression of Cyclin A2 and CDK2. Exposure to PFAS may potentially elevate the risk of chemotherapy resistance in CRC, a finding that has significant implications for clinical treatment and chemical risk assessment.
    Journal
    |
    CCNA2 (Cyclin A2) • CDK2 (Cyclin-dependent kinase 2)
    |
    5-fluorouracil • oxaliplatin • irinotecan