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irinotecan liposomal
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Company:
CSPC Pharma
Drug class:
Topoisomerase I inhibitor
Related drugs:
4ms
Liposomal Irinotecan in Combination With Oxaliplatin and S-1 Versus Gemcitabine Combined With Capecitabine as Postoperative Adjuvant Therapy for Pancreatic Cancer (clinicaltrials.gov)
P3, N=408, Not yet recruiting, CSPC Ouyi Pharmaceutical Co., Ltd.
New P3 trial • Combination therapy
|
gemcitabine • capecitabine • Teysuno (gimeracil/oteracil/tegafur) • irinotecan liposomal
5ms
Study of Irinotecan Liposome Injection in Patients With Advanced Breast Cance (clinicaltrials.gov)
P1, N=119, Completed, CSPC Ouyi Pharmaceutical Co., Ltd. | Not yet recruiting --> Completed
Trial completion • Metastases
|
HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
irinotecan liposomal
5ms
Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer (clinicaltrials.gov)
P2, N=17, Terminated, CSPC Ouyi Pharmaceutical Co., Ltd. | N=66 --> 17 | Not yet recruiting --> Terminated; Internal strategy change. Not related to safety concerns.
Enrollment change • Trial termination • Metastases
|
5-fluorouracil • leucovorin calcium • Enshuxing (enlonstobart) • irinotecan liposomal
5ms
Study of Irinotecan Liposome Injection as Second-line Regimen in Patients With Small Cell Lung Cancer (SCLC) (clinicaltrials.gov)
P2, N=66, Completed, CSPC Ouyi Pharmaceutical Co., Ltd. | Not yet recruiting --> Completed
Trial completion
|
irinotecan liposomal
5ms
Phase I Dose Escalation and Pharmacokinetics Clinical Trial of Mitoxantrone Hydrochloride Liposome in Children With Relapsed and Refractory Lymphoma and Solid Tumors (clinicaltrials.gov)
P1, N=68, Active, not recruiting, Sun Yat-sen University | Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2024 --> Sep 2024
Enrollment closed • Trial primary completion date
|
vincristine • Duoenda (mitoxantrone liposomal) • irinotecan liposomal
8ms
Irinotecan Liposome Combined With Oxaliplatin and Tegafur as Adjuvant Therapy for Pancreatic Cancer (clinicaltrials.gov)
P=N/A, N=53, Recruiting, Kuirong Jiang
New trial
|
irinotecan liposomal
10ms
Efficacy and Safety of Irinotecan Liposome Injection Combined With 5-FU/LV± Immunotherapy in First-line Gemsitabine + Immunoprogressive Patients With Metastatic Biliary Tract Cancer (clinicaltrials.gov)
P=N/A, N=30, Recruiting, Tianjin Medical University Cancer Institute and Hospital
New trial
|
5-fluorouracil • leucovorin calcium • irinotecan liposomal
11ms
Dose Escalation and Expansion Clinical Trial of Irinotecan Liposome Combined With Oxaliplatin and 5-FU/LV Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer (clinicaltrials.gov)
P1, N=78, Recruiting, Shanghai Zhongshan Hospital
New P1 trial • Metastases
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UGT1A1*1*1
|
Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • irinotecan liposomal
3years
Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer (clinicaltrials.gov)
P2, N=66, Not yet recruiting, CSPC Ouyi Pharmaceutical Co., Ltd. | Trial completion date: Aug 2021 --> Aug 2024 | Trial primary completion date: Aug 2021 --> Aug 2023
Clinical • Trial completion date • Trial primary completion date
|
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*1*1
|
5-fluorouracil • leucovorin calcium • Enshuxing (enlonstobart) • irinotecan liposomal
over3years
Study of Irinotecan Liposome Injection-containing Regimens Versus Nab-paclitaxel Plus Gemcitabine in Patients With Previously Untreated, Metastatic Pancreatic Adenocarcinoma (clinicaltrials.gov)
P2, N=153, Not yet recruiting, CSPC Ouyi Pharmaceutical Co., Ltd.
Clinical • New P2 trial
|
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*1*1
|
gemcitabine • 5-fluorouracil • albumin-bound paclitaxel • oxaliplatin • leucovorin calcium • irinotecan liposomal
over3years
Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer (clinicaltrials.gov)
P2, N=66, Not yet recruiting, CSPC Ouyi Pharmaceutical Co., Ltd.
Clinical • New P2 trial
|
UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
|
UGT1A1*1*1
|
5-fluorouracil • leucovorin calcium • Enshuxing (enlonstobart) • irinotecan liposomal
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