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    DRUG:

    IMGN779

    i
    Other names: IMGN779, IMGN 779
    Company:
    AbbVie, Jazz
    Drug class:
    DNA replication inhibitor, CD33-targeted antibody-drug conjugate
    Related drugs:
    4years
    CD33-Targeted Therapies: Beating the Disease or Beaten to Death? (PubMed, J Clin Pharmacol)
    Gemtuzumab ozogamicin was the first and only CD33-directed antibody-drug conjugate to be US Food and Drug Administration approved for AML...Promising new strategies include cellular therapy mechanisms and linker molecules. This is an exciting target that requires a considerable amount of precision to yield clinical benefit.
    Review • Journal
    |
    CD33 (CD33 Molecule)
    |
    Mylotarg (gemtuzumab ozogamicin) • IMGN779 • vadastuximab talirine (SGN-CD33A) • vixtimotamab (AMV564) • AVE9633 • GTB-3550 TRIKE • eluvixtamab (AMG 330)