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DRUG:

brenetafusp (IMC-F106C)

i
Other names: IMC-F106C, IMCF106C, IMC F106C
Company:
Immunocore
Drug class:
CD3 agonist, PRAME inhibitor
Related drugs:
25d
IMC-F106C-101: Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors (clinicaltrials.gov)
P1/2, N=727, Recruiting, Immunocore Ltd | Trial primary completion date: Jun 2026 --> Feb 2026
Trial primary completion date
|
HLA-A (Major Histocompatibility Complex, Class I, A) • PRAME (Preferentially Expressed Antigen In Melanoma)
|
HLA-A*02
|
Keytruda (pembrolizumab) • Avastin (bevacizumab) • Kimmtrak (tebentafusp-tebn) • brenetafusp (IMC-F106C)
8ms
Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors (clinicaltrials.gov)
P1/2, N=727, Recruiting, Immunocore Ltd | N=170 --> 727 | Trial completion date: Feb 2026 --> Jun 2026 | Trial primary completion date: Feb 2024 --> Jun 2026
Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Checkpoint inhibition
|
HLA-A (Major Histocompatibility Complex, Class I, A) • PRAME (Preferentially Expressed Antigen In Melanoma)
|
HLA-A*02
|
Keytruda (pembrolizumab) • Avastin (bevacizumab) • Kimmtrak (tebentafusp-tebn) • brenetafusp (IMC-F106C)
9ms
Enrollment open • Metastases
|
BRAF (B-raf proto-oncogene) • HLA-A (Major Histocompatibility Complex, Class I, A)
|
BRAF mutation • BRAF V600 • HLA-A*02
|
Opdualag (nivolumab/relatlimab-rmbw) • brenetafusp (IMC-F106C) • relatlimab (BMS-986016)
1year
New P3 trial • Metastases
|
BRAF (B-raf proto-oncogene) • HLA-A (Major Histocompatibility Complex, Class I, A) • CD163 (CD163 Molecule)
|
BRAF mutation • BRAF V600 • HLA-A*02
|
Opdualag (nivolumab/relatlimab-rmbw) • brenetafusp (IMC-F106C) • relatlimab (BMS-986016)
over2years
Results from phase I dose escalation of IMC-F106C, the first PRAME × CD3 ImmTAC bispecific protein in solid tumors (ESMO 2022)
ImmTAC bispecifics redirect polyclonal T cells to target intra/extracellular cancer proteins, as validated by tebentafusp (tebe; gp100×CD3 ImmTAC) with an overall survival benefit in metastatic uveal melanoma (mUM). Conclusions IMC-F106C, the first PRAME×CD3 ImmTAC, is well tolerated and demonstrated durable RECIST partial responses and ctDNA response in PRAME+ pts across multiple tumor types. Dose escalation and multiple expansions are ongoing.
P1 data • PD(L)-1 Biomarker • IO biomarker
|
HLA-A (Major Histocompatibility Complex, Class I, A) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • PRAME (Preferentially Expressed Antigen In Melanoma)
|
HLA-A*02
|
Kimmtrak (tebentafusp-tebn) • brenetafusp (IMC-F106C)
over2years
Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors (clinicaltrials.gov)
P1/2, N=170, Recruiting, Immunocore Ltd | Trial completion date: Feb 2024 --> Feb 2026 | Trial primary completion date: Feb 2022 --> Feb 2024
Trial completion date • Trial primary completion date • Combination therapy • Checkpoint inhibition
|
HLA-A (Major Histocompatibility Complex, Class I, A) • PRAME (Preferentially Expressed Antigen In Melanoma)
|
HLA-A*02
|
brenetafusp (IMC-F106C)
over4years
[VIRTUAL] IMC-F106C, a novel and potent immunotherapy approach to treat PRAME expressing solid and hematologic tumors (AACR-II 2020)
These data indicate that PRAME is expressed in a number of solid tumors, and is highly prevalent in lung tumours, irrespective of EGFR status, as well as female-oriented cancers. In conjunction, IMC-F106C efficiently redirects T cell activity against tumor cell lines that express PRAME across a range of tumor indications. Taken together, IMC-F106C could prove to be a highly effective immunotherapy option for HLA*02:01 positive patients with PRAME positive tumors.
IO biomarker
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EGFR (Epidermal growth factor receptor) • IFNG (Interferon, gamma) • PRAME (Preferentially Expressed Antigen In Melanoma)
|
PRAME expression
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brenetafusp (IMC-F106C)