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DRUG:

GEN3017

i
Other names: GEN3017, DuoBody-CD3xCD30
Associations
Company:
Genmab
Drug class:
CD3 agonist, CD30 inhibitor
Related drugs:
Associations
4d
A First-in-human Trial of GEN3017 in Hodgkin Lymphoma and Non-Hodgkin Lymphoma (clinicaltrials.gov)
P1/2, N=240, Active, not recruiting, Genmab | Recruiting --> Active, not recruiting
Enrollment closed
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TNFRSF8 (TNF Receptor Superfamily Member 8)
|
TNFRSF8 positive
|
GEN3017
12ms
A First-in-human Trial of GEN3017 in Hodgkin Lymphoma and Non-Hodgkin Lymphoma (clinicaltrials.gov)
P1/2, N=240, Recruiting, Genmab | Trial completion date: Jun 2028 --> Dec 2032
Trial completion date
|
TNFRSF8 (TNF Receptor Superfamily Member 8)
|
TNFRSF8 positive
|
GEN3017
1year
A First-in-human Trial of GEN3017 in Hodgkin Lymphoma and Non-Hodgkin Lymphoma (clinicaltrials.gov)
P1/2, N=240, Recruiting, Genmab | Not yet recruiting --> Recruiting
Enrollment open
|
TNFRSF8 (TNF Receptor Superfamily Member 8)
|
TNFRSF8 positive
|
GEN3017
1year
New P1/2 trial
|
TNFRSF8 (TNF Receptor Superfamily Member 8)
|
TNFRSF8 positive
|
GEN3017
2years
Duobody-CD3xCD30 Demonstrates Potent Anti-Tumor Activity in Preclinical Models of CD30+ Hematologic Malignancies (ASH 2022)
In the last decade, treatment regimen including brentuximab vedotin have significantly improved prognosis for patients with CD30-expressing lymphomas...Here, we report preclinical data for the novel DuoBody®-CD3xCD30 (GEN3017), a CD3 bsAb targeting CD30-expressing tumor cells...CD30-expressing HL (L428) and ALCL (KI-JK) tumor cell lines were incubated with purified healthy donor T cells (E:T ratio = 4:1) and DuoBody-CD3xCD30 or bsIgG1-CD3xctrl for 72 hours. T-cell mediated cytotoxicity was measured by flow cytometry and expressed as the percentage viable tumor cells normalized to an untreated control sample.
Preclinical
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CD8 (cluster of differentiation 8) • TNFRSF8 (TNF Receptor Superfamily Member 8) • CD4 (CD4 Molecule)
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TNFRSF8 expression
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Adcetris (brentuximab vedotin) • GEN3017