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    DRUG:

    conteltinib (SY-707)

    i
    Other names: CT-707, CT 707, SY-707
    Company:
    Centaurus Biopharma, Shouyao Holdings
    Drug class:
    ALK inhibitor, Multi-tyrosine kinase inhibitor, IGF-1R inhibitor, FAK inhibitor, Pyk2 inhibitor
    Related drugs:
    over1year
    Conteltinib (CT-707) in patients with advanced ALK-positive non-small cell lung cancer: a multicenter, open-label, first-in-human phase 1 study. (PubMed, BMC Med)
    In this study, conteltinib showed manageable safety profile, favorable PK properties, and anti-tumor activity in advanced ALK-positive NSCLC patients. The recommended phase 2 dose was determined to be 600 mg QD for ALK TKI-naïve patients and 300 mg bis in die (BID) for patients who received crizotinib previously.
    P1 data • Journal
    |
    ALK (Anaplastic lymphoma kinase)
    |
    ALK positive
    |
    Xalkori (crizotinib) • conteltinib (SY-707)