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DRUG:

ganitumab (AMG 479)

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Company:

ImmunityBio, Takeda

Drug class:

IGF-1R inhibitor

Related drugs:

IGF1 elevation	Pancreatic Cancer	IGF1 elevation	Pancreatic Cancer	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3
IGF2 elevation	Pancreatic Cancer	IGF2 elevation	Pancreatic Cancer	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3
IGFBP2-L	Pancreatic Cancer	IGFBP2-L	Pancreatic Cancer	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3
IGFBP3 elevation	Pancreatic Cancer	IGFBP3 elevation	Pancreatic Cancer	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3
HR negative	HER2 Negative Breast Cancer	HR negative	HER2 Negative Breast Cancer	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3
IGFBP5-L	HER2 Negative Breast Cancer	IGFBP5-L	HER2 Negative Breast Cancer	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3
IRS1-L	HER2 Negative Breast Cancer	IRS1-L	HER2 Negative Breast Cancer	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3	AMG 479 Sensitive: C3 – Early Trials AMG 479 Sensitive : C3
IGF2 elevation	Ovarian Cancer	IGF2 elevation	Ovarian Cancer	AMG 479 Sensitive: D – Preclinical AMG 479 Sensitive : D	AMG 479 Sensitive: D – Preclinical AMG 479 Sensitive : D
PTEN mutation	Ovarian Cancer	PTEN mutation	Ovarian Cancer	AMG 479 Resistant: D – Preclinical AMG 479 Resistant : D	AMG 479 Resistant: D – Preclinical AMG 479 Resistant : D
RAS mutation	Rhabdomyosarcoma	RAS mutation	Rhabdomyosarcoma	trametinib + AMG 479 Sensitive: D – Preclinical trametinib + AMG 479 Sensitive : D	trametinib + AMG 479 Sensitive: D – Preclinical trametinib + AMG 479 Sensitive : D