Cometriq (cabozantinib capsule)

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Company:

Exelixis, Ipsen, Takeda

Drug class:

Multi-tyrosine kinase inhibitor

Related drugs:

No biomarker	Thyroid Gland Medullary Carcinoma	No biomarker	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: A1 - Approval cabozantinib capsule Sensitive : A1	cabozantinib capsule Sensitive: A1 - Approval cabozantinib capsule Sensitive : A1
RET M918T	Thyroid Gland Medullary Carcinoma	RET M918T	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: A2 - Guideline cabozantinib capsule Sensitive : A2	cabozantinib capsule Sensitive: A2 - Guideline cabozantinib capsule Sensitive : A2
RAS mutation	Thyroid Gland Medullary Carcinoma	RAS mutation	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: A2 - Guideline cabozantinib capsule Sensitive : A2	cabozantinib capsule Sensitive: A2 - Guideline cabozantinib capsule Sensitive : A2
KRAS mutation	Thyroid Gland Medullary Carcinoma	KRAS mutation	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B
NRAS mutation	Thyroid Gland Medullary Carcinoma	NRAS mutation	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B
KRAS mutation	Thyroid Gland Medullary Carcinoma	KRAS mutation	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B
MET mutation	Renal Cell Carcinoma	MET mutation	Renal Cell Carcinoma	cabozantinib capsule Sensitive: C2 – Inclusion Criteria cabozantinib capsule Sensitive : C2	cabozantinib capsule Sensitive: C2 – Inclusion Criteria cabozantinib capsule Sensitive : C2
RET fusion	Non Small Cell Lung Cancer	RET fusion	Non Small Cell Lung Cancer	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
GNAQ mutation	Uveal Melanoma	GNAQ mutation	Uveal Melanoma	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
GNA11 mutation	Uveal Melanoma	GNA11 mutation	Uveal Melanoma	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
KIF5B-RET fusion	Non Small Cell Lung Cancer	KIF5B-RET fusion	Non Small Cell Lung Cancer	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
CTNNB1 mutation	Non Small Cell Lung Cancer	CTNNB1 mutation	Non Small Cell Lung Cancer	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
CCDC6-RET fusion	Non Small Cell Lung Cancer	CCDC6-RET fusion	Non Small Cell Lung Cancer	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
HR positive	HER2 Negative Breast Cancer	HR positive	HER2 Negative Breast Cancer	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
HLA-DRB1-MET fusion	Non Small Cell Lung Cancer	HLA-DRB1-MET fusion	Non Small Cell Lung Cancer	cabozantinib capsule Sensitive: C4 – Case Studies cabozantinib capsule Sensitive : C4	cabozantinib capsule Sensitive: C4 – Case Studies cabozantinib capsule Sensitive : C4
EGFR exon 19 deletion + MET Amplification + MET D1228V	Lung Adenocarcinoma	EGFR exon 19 deletion + MET Amplification + MET D1228V	Lung Adenocarcinoma	erlotinib + cabozantinib capsule Sensitive: C4 – Case Studies erlotinib + cabozantinib capsule Sensitive : C4	erlotinib + cabozantinib capsule Sensitive: C4 – Case Studies erlotinib + cabozantinib capsule Sensitive : C4
MET D1228V	Non Small Cell Lung Cancer	MET D1228V	Non Small Cell Lung Cancer	erlotinib + cabozantinib capsule Sensitive: C4 – Case Studies erlotinib + cabozantinib capsule Sensitive : C4	erlotinib + cabozantinib capsule Sensitive: C4 – Case Studies erlotinib + cabozantinib capsule Sensitive : C4
MET overexpression	Adrenal Cortex Carcinoma	MET overexpression	Adrenal Cortex Carcinoma	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D
CCDC6-RET fusion	Lung Adenocarcinoma	CCDC6-RET fusion	Lung Adenocarcinoma	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D
GNAS amplification	Renal Cell Carcinoma	GNAS amplification	Renal Cell Carcinoma	cabozantinib capsule Resistant: D – Preclinical cabozantinib capsule Resistant : D	cabozantinib capsule Resistant: D – Preclinical cabozantinib capsule Resistant : D
RET C634W	Thyroid Gland Medullary Carcinoma	RET C634W	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D
RET-PTC1 rearrangement	Thyroid Gland Papillary Carcinoma	RET-PTC1 rearrangement	Thyroid Gland Papillary Carcinoma	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D
ADCYAP1 deletion	Renal Cell Carcinoma	ADCYAP1 deletion	Renal Cell Carcinoma	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D
BCR-ABL1 V299L	Acute Lymphocytic Leukemia	BCR-ABL1 V299L	Acute Lymphocytic Leukemia	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D	cabozantinib capsule Sensitive: D – Preclinical cabozantinib capsule Sensitive : D

Cometriq (cabozantinib capsule)

Associations
(24)

Associations
(24)

Cometriq (cabozantinib capsule)

Associations(24)

Associations(24)

Associations
(24)

Associations
(24)