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DRUG:

CDR101

i
Other names: CDR101, BCMAxCD3xPD-L1 trispecific antibody , CDR-101, CDR 101
Associations
Trials
Company:
CDR-Life
Drug class:
PD-L1 inhibitor, BCMA inhibitor, T-cell stimulant, CD3 modulator
Related drugs:
Associations
Trials
3years
Preclinical Assessment of CDR101 – a BCMAxCD3xPD-L1 Trispecific Antibody with Superior Anti-Tumor Efficacy (ASH 2021)
In contrast to high-affinity PD-L1 immune checkpoint inhibitors, CDR101 selectively inhibits PD-L1 at the immune synapse preventing on-target off-tumor effects. This is expected to translate into a decreased incidence of immune related adverse events (irAEs) and better efficacy arguing for a high clinical potential and swift translation into the clinic.
Preclinical • PD(L)-1 Biomarker • IO biomarker
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IL2RA (Interleukin 2 receptor, alpha) • SDC1 (Syndecan 1)
|
PD-L1 expression • SDC1 positive
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CDR101