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    DRUG:

    AZD8205

    i
    Other names: AZD8205
    Company:
    AstraZeneca
    Drug class:
    Topoisomerase I inhibitor, B7-H4-targeted antibody-drug conjugate
    Related drugs:
    11ms
    Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors. (PubMed, Clin Cancer Res)
    Spatial analysis revealed that ACC subtypes have distinct TMEs, with enrichment of ACC-I immune cells that are restricted to the stroma. B7-H4 is highly expressed in poor-prognosis ACC-I subtype and is a potential therapeutic target.
    Journal
    |
    VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1)
    |
    VTCN1 underexpression
    |
    AZD8205
    1year
    Preclinical evaluation of a novel B7-H4 targeted antibody-drug conjugate AZD8205 as a single agent and in combination with novel PARP inhibitor and checkpoint blockade (AACR 2023)
    To further exploit the DNA damage elicited by the specific delivery of the TOP1i warhead, the combination of AZD8205 with a novel poly-ADP ribose polymerase 1 (PARP1) selective inhibitor, AZD5305, was investigated. These data demonstrate that AZD8205 is a promising therapeutic candidate for the treatment of B7-H4 positive solid tumors. A first in human phase I/IIa study in patients with advanced solid tumors is currently ongoing (NCT05123482).
    Preclinical • Combination therapy • Checkpoint inhibition • PARP Biomarker • PD(L)-1 Biomarker • IO biomarker • Checkpoint block
    |
    HRD (Homologous Recombination Deficiency) • VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1)
    |
    VTCN1 underexpression
    |
    AZD8205 • saruparib (AZD5305)
    2years
    First-in-human study of the B7-H4 antibody-drug conjugate (ADC) AZD8205 in patients with advanced/metastatic solid tumors. (ASCO 2022)
    Secondary objectives include assessing initial activity (objective response and progression-free survival by RECIST v1.1, and overall survival), pharmacodynamics, pharmacokinetics, and immunogenicity. The trial is currently recruiting and will enroll patients globally.
    Clinical • P1 data
    |
    VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1)
    |
    VTCN1 underexpression
    |
    AZD8205
    2years
    Discovery and first disclosure of AZD8205, a B7-H4-targeted antibody-drug conjugate utilizing a novel topoisomerase I linker-warhead (AACR 2022)
    These data suggest that AZD8205 is a promising therapeutic candidate for the treatment of B7-H4 positive solid tumors. A first in human phase 1 study in patients with advanced solid tumors is currently ongoing (NCT05123482).
    BRCA Biomarker • PARP Biomarker
    |
    BRCA (Breast cancer early onset) • VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1)
    |
    BRCA wild-type • VTCN1 underexpression
    |
    AZD8205