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DRUG:

seribantumab (MM-121)

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Company:

Elevation Oncology, Merrimack

Drug class:

HER3 inhibitor

Related drugs:

NRG1 fusion	Solid Tumor	NRG1 fusion	Solid Tumor	MM-121 Sensitive: B - Late Trials MM-121 Sensitive : B	MM-121 Sensitive: B - Late Trials MM-121 Sensitive : B
NRG1 fusion	Lung Cancer	NRG1 fusion	Lung Cancer	MM-121 Sensitive: C2 – Inclusion Criteria MM-121 Sensitive : C2	MM-121 Sensitive: C2 – Inclusion Criteria MM-121 Sensitive : C2
NRG1 fusion	Ovarian Cancer	NRG1 fusion	Ovarian Cancer	MM-121 Sensitive: C2 – Inclusion Criteria MM-121 Sensitive : C2	MM-121 Sensitive: C2 – Inclusion Criteria MM-121 Sensitive : C2
CLU-NRG1 fusion	Ovarian Cancer	CLU-NRG1 fusion	Ovarian Cancer	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D
SLC3A2-NRG1 fusion	Pancreatic Ductal Adenocarcinoma	SLC3A2-NRG1 fusion	Pancreatic Ductal Adenocarcinoma	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D
ATP1B1-NRG1 fusion	Pancreatic Ductal Adenocarcinoma	ATP1B1-NRG1 fusion	Pancreatic Ductal Adenocarcinoma	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D
CD74-NRG1 fusion	Lung Cancer	CD74-NRG1 fusion	Lung Cancer	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D
SLC3A2-NRG1 fusion	Lung Cancer	SLC3A2-NRG1 fusion	Lung Cancer	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D
TENM4-NRG1 fusion	Breast Cancer	TENM4-NRG1 fusion	Breast Cancer	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D
NRG1 amplification	Lung Cancer	NRG1 amplification	Lung Cancer	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D
KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D
KRAS wild-type	Colorectal Cancer	KRAS wild-type	Colorectal Cancer	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D	MM-121 Sensitive: D – Preclinical MM-121 Sensitive : D