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DRUG:

sotrastaurin (AEB071)

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Company:

Novartis

Drug class:

PKC inhibitor

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GNAQ mutation	Uveal Melanoma	GNAQ mutation	Uveal Melanoma	AEB071 Sensitive: C3 – Early Trials AEB071 Sensitive : C3	AEB071 Sensitive: C3 – Early Trials AEB071 Sensitive : C3
GNA11 mutation	Uveal Melanoma	GNA11 mutation	Uveal Melanoma	AEB071 Sensitive: C3 – Early Trials AEB071 Sensitive : C3	AEB071 Sensitive: C3 – Early Trials AEB071 Sensitive : C3
GNAQ Q209L	Uveal Melanoma	GNAQ Q209L	Uveal Melanoma	AEB071 Sensitive: D – Preclinical AEB071 Sensitive : D	AEB071 Sensitive: D – Preclinical AEB071 Sensitive : D
GNA11 mutation	Uveal Melanoma	GNA11 mutation	Uveal Melanoma	AEB071 + AHT956 Sensitive: D – Preclinical AEB071 + AHT956 Sensitive : D	AEB071 + AHT956 Sensitive: D – Preclinical AEB071 + AHT956 Sensitive : D
GNAQ mutation	Uveal Melanoma	GNAQ mutation	Uveal Melanoma	AEB071 + AHT956 Sensitive: D – Preclinical AEB071 + AHT956 Sensitive : D	AEB071 + AHT956 Sensitive: D – Preclinical AEB071 + AHT956 Sensitive : D
GNAQ Q209P	Uveal Melanoma	GNAQ Q209P	Uveal Melanoma	AEB071 Sensitive: D – Preclinical AEB071 Sensitive : D	AEB071 Sensitive: D – Preclinical AEB071 Sensitive : D
GNAQ Q209L	Uveal Melanoma	GNAQ Q209L	Uveal Melanoma	binimetinib + AEB071 Sensitive: D – Preclinical binimetinib + AEB071 Sensitive : D	binimetinib + AEB071 Sensitive: D – Preclinical binimetinib + AEB071 Sensitive : D
GNAQ mutation	Uveal Melanoma	GNAQ mutation	Uveal Melanoma	AEB071 + CGM097 Sensitive: D – Preclinical AEB071 + CGM097 Sensitive : D	AEB071 + CGM097 Sensitive: D – Preclinical AEB071 + CGM097 Sensitive : D
GNA11 mutation	Uveal Melanoma	GNA11 mutation	Uveal Melanoma	binimetinib + AEB071 Sensitive: D – Preclinical binimetinib + AEB071 Sensitive : D	binimetinib + AEB071 Sensitive: D – Preclinical binimetinib + AEB071 Sensitive : D
GNAQ mutation	Uveal Melanoma	GNAQ mutation	Uveal Melanoma	everolimus + AEB071 Sensitive: D – Preclinical everolimus + AEB071 Sensitive : D	everolimus + AEB071 Sensitive: D – Preclinical everolimus + AEB071 Sensitive : D
GNAQ mutation	Uveal Melanoma	GNAQ mutation	Uveal Melanoma	binimetinib + AEB071 Sensitive: D – Preclinical binimetinib + AEB071 Sensitive : D	binimetinib + AEB071 Sensitive: D – Preclinical binimetinib + AEB071 Sensitive : D
GNA11 mutation	Uveal Melanoma	GNA11 mutation	Uveal Melanoma	AEB071 + CGM097 Sensitive: D – Preclinical AEB071 + CGM097 Sensitive : D	AEB071 + CGM097 Sensitive: D – Preclinical AEB071 + CGM097 Sensitive : D
GNA11 mutation	Uveal Melanoma	GNA11 mutation	Uveal Melanoma	everolimus + AEB071 Sensitive: D – Preclinical everolimus + AEB071 Sensitive : D	everolimus + AEB071 Sensitive: D – Preclinical everolimus + AEB071 Sensitive : D
GNA11 mutation	Uveal Melanoma	GNA11 mutation	Uveal Melanoma	PD-0325901 + AEB071 Sensitive: D – Preclinical PD-0325901 + AEB071 Sensitive : D	PD-0325901 + AEB071 Sensitive: D – Preclinical PD-0325901 + AEB071 Sensitive : D
GNAQ mutation	Uveal Melanoma	GNAQ mutation	Uveal Melanoma	PD-0325901 + AEB071 Sensitive: D – Preclinical PD-0325901 + AEB071 Sensitive : D	PD-0325901 + AEB071 Sensitive: D – Preclinical PD-0325901 + AEB071 Sensitive : D
ER positive	HER2 Positive Breast Cancer	ER positive	HER2 Positive Breast Cancer	AEB071 Sensitive: D – Preclinical AEB071 Sensitive : D	AEB071 Sensitive: D – Preclinical AEB071 Sensitive : D
ER positive	Estrogen Receptor Positive Breast Cancer	ER positive	Estrogen Receptor Positive Breast Cancer	AEB071 Sensitive: D – Preclinical AEB071 Sensitive : D	AEB071 Sensitive: D – Preclinical AEB071 Sensitive : D