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Association details:
Biomarker:GNAQ mutation
Cancer:Uveal Melanoma
Drug:sotrastaurin (AEB071) (PKC inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Title:

Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071

Excerpt:
Patients with metastatic UM (n = 153) were treated with AEB071 in a phase I, single-arm study. GNAQ/GNA11 mutations were observed at a similar frequency (93%) as previously reported, confirming a therapeutic window for inhibition of the downstream effector PKC in metastatic UM. In conclusion, the protein kinase C inhibitor AEB071 was well tolerated, and modest clinical activity was observed in metastatic UM.
DOI:
10.1158/1535-7163.MCT-19-0098