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    Association details:
    Biomarker:GNA11 mutation
    Cancer:Uveal Melanoma
    Drug:sotrastaurin (AEB071) (PKC inhibitor) +
    CGM097 (MDM2 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Mol Cell Oncol
    Title:

    YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations

    Excerpt:
    We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells….In a subcutaneous xenograft mouse model, UM cells (92.1, GqQ209L) were able to form solid tumors in immunocompromised mice….YAP inhibition suppresses the growth of uveal melanoma cells bearing GNAQ or GNA11 mutations.
    DOI:
    10.4161/23723548.2014.970957