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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations

Excerpt:
We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells….In a subcutaneous xenograft mouse model, UM cells (92.1, GqQ209L) were able to form solid tumors in immunocompromised mice….YAP inhibition suppresses the growth of uveal melanoma cells bearing GNAQ or GNA11 mutations.
DOI:
10.4161/23723548.2014.970957