^
Association details:
| Biomarker: | GNA11 mutation |
|---|---|
| Cancer: | Uveal Melanoma |
| Drug: | sotrastaurin (AEB071) (PKC inhibitor) + AHT956 (PKC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations
Excerpt:
The selective effect of AEB071 and AHT956 on cells with GNAQ or GNA11 mutations was also reflected in the growth curves of the cell lines, with GNAQ-mutant cells revealing a dose-dependent growth inhibition compared to cell lines without GNAQ or GNA11 mutations...
DOI:
10.1038/onc.2013.418
