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Association details:
| Biomarker: | GNAQ Q209P |
|---|---|
| Cancer: | Uveal Melanoma |
| Drug: | sotrastaurin (AEB071) (PKC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-?B pathways
Excerpt:
...while codon 209 of GNAQ is mutated from CAA (glutamine) to CTA (leucine) in cell lines Mel202 and 92.1 and to CCA (proline) in cell line Omm1.3...Along with decreased viability, microscopic examination found morphological alterations in AEB071 treated cells harboring GNAQ mutations but not wild type GNAQ or normal melanocytes (Figure 1D)....These results indicate that AEB071 selectively induced apoptosis in UM cells harboring GNAQ mutations.
DOI:
10.1158/1535-7163.MCT-12-0121
