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GENE:

RARA (Retinoic Acid Receptor Alpha)

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PML-RARA fusion	Acute Promyelocytic Leukemia	PML-RARA fusion	Acute Promyelocytic Leukemia	arsenic trioxide Sensitive: A1 - Approval arsenic trioxide Sensitive : A1	arsenic trioxide Sensitive: A1 - Approval arsenic trioxide Sensitive : A1
PML-RARA fusion	Acute Myelogenous Leukemia	PML-RARA fusion	Acute Myelogenous Leukemia	venetoclax Sensitive: C3 – Early Trials venetoclax Sensitive : C3	venetoclax Sensitive: C3 – Early Trials venetoclax Sensitive : C3
RARA positive	Acute Myelogenous Leukemia	RARA positive	Acute Myelogenous Leukemia	tamibarotene Sensitive: C3 – Early Trials tamibarotene Sensitive : C3	tamibarotene Sensitive: C3 – Early Trials tamibarotene Sensitive : C3
RARA overexpression	Acute Myelogenous Leukemia	RARA overexpression	Acute Myelogenous Leukemia	venetoclax Resistant: C3 – Early Trials venetoclax Resistant : C3	venetoclax Resistant: C3 – Early Trials venetoclax Resistant : C3
Chr t(15;17)/PML-RARA fusion	Acute Myelogenous Leukemia	Chr t(15;17)/PML-RARA fusion	Acute Myelogenous Leukemia	venetoclax + ruxolitinib Resistant: C3 – Early Trials venetoclax + ruxolitinib Resistant : C3	venetoclax + ruxolitinib Resistant: C3 – Early Trials venetoclax + ruxolitinib Resistant : C3
PML-RARA fusion	Acute Promyelocytic Leukemia	PML-RARA fusion	Acute Promyelocytic Leukemia	tretinoin + arsenic trioxide Sensitive: C3 – Early Trials tretinoin + arsenic trioxide Sensitive : C3	tretinoin + arsenic trioxide Sensitive: C3 – Early Trials tretinoin + arsenic trioxide Sensitive : C3
RARA overexpression	Acute Myelogenous Leukemia	RARA overexpression	Acute Myelogenous Leukemia	azacitidine + tamibarotene Sensitive: C3 – Early Trials azacitidine + tamibarotene Sensitive : C3	azacitidine + tamibarotene Sensitive: C3 – Early Trials azacitidine + tamibarotene Sensitive : C3
STAT5b-RARA fusion	Acute Promyelocytic Leukemia	STAT5b-RARA fusion	Acute Promyelocytic Leukemia	DCAG Sensitive: C4 – Case Studies DCAG Sensitive : C4	DCAG Sensitive: C4 – Case Studies DCAG Sensitive : C4
PML-RARA fusion	Acute Promyelocytic Leukemia	PML-RARA fusion	Acute Promyelocytic Leukemia	cytarabine + idarubicin hydrochloride + tretinoin Sensitive: C4 – Case Studies cytarabine + idarubicin hydrochloride + tretinoin Sensitive : C4	cytarabine + idarubicin hydrochloride + tretinoin Sensitive: C4 – Case Studies cytarabine + idarubicin hydrochloride + tretinoin Sensitive : C4
PML-RARA fusion	Acute Myelogenous Leukemia	PML-RARA fusion	Acute Myelogenous Leukemia	tretinoin Sensitive: C4 – Case Studies tretinoin Sensitive : C4	tretinoin Sensitive: C4 – Case Studies tretinoin Sensitive : C4
FLT3-ITD mutation + PML-RARA fusion + WT1 overexpression	Acute Promyelocytic Leukemia	FLT3-ITD mutation + PML-RARA fusion + WT1 overexpression	Acute Promyelocytic Leukemia	cytarabine + idarubicin hydrochloride + arsenic trioxide + hydroxyurea Sensitive: C4 – Case Studies cytarabine + idarubicin hydrochloride + arsenic trioxide + hydroxyurea Sensitive : C4	cytarabine + idarubicin hydrochloride + arsenic trioxide + hydroxyurea Sensitive: C4 – Case Studies cytarabine + idarubicin hydrochloride + arsenic trioxide + hydroxyurea Sensitive : C4
PML-RARA T285I	Acute Promyelocytic Leukemia	PML-RARA T285I	Acute Promyelocytic Leukemia	venetoclax Sensitive: C4 – Case Studies venetoclax Sensitive : C4	venetoclax Sensitive: C4 – Case Studies venetoclax Sensitive : C4