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    Association details:
    Biomarker:PML-RARA fusion
    Cancer:Acute Myelogenous Leukemia
    Drug:Venclexta (venetoclax) (Bcl2 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    ASH 2018
    Title:

    Biomarkers Predicting Venetoclax Sensitivity and Strategies for Venetoclax Combination Treatment

    Published date:
    11/01/2018
    Excerpt:
    ...we observed that AML samples harboring PML-RARA translocations, WT1, and FLT3 with IDH1 mutations are more sensitive to venetoclax, and samples with TET2, KRAS, PTPN11 and SF3B1 mutations are more resistant.
    DOI:
    https://doi.org/10.1182/blood-2018-175