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BIOMARKER:

PTCH1 mutation

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Entrez ID:

Related biomarkers:

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PTCH1-GLI1 fusion (2)

PTCH1-GLI1 fusion (2)

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PTCH1 mutation	Hormone Receptor Positive Breast Cancer	PTCH1 mutation	Hormone Receptor Positive Breast Cancer	lenvatinib Sensitive: C3 – Early Trials lenvatinib Sensitive : C3	lenvatinib Sensitive: C3 – Early Trials lenvatinib Sensitive : C3
PTCH1 mutation	Medulloblastoma	PTCH1 mutation	Medulloblastoma	vismodegib Sensitive: C3 – Early Trials vismodegib Sensitive : C3	vismodegib Sensitive: C3 – Early Trials vismodegib Sensitive : C3
PTCH1 mutation	Colorectal Cancer	PTCH1 mutation	Colorectal Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
PTCH1 mutation	Melanoma	PTCH1 mutation	Melanoma	vismodegib Sensitive: C3 – Early Trials vismodegib Sensitive : C3	vismodegib Sensitive: C3 – Early Trials vismodegib Sensitive : C3
PTCH1 mutation	Salivary Gland Cancer	PTCH1 mutation	Salivary Gland Cancer	vismodegib Sensitive: C3 – Early Trials vismodegib Sensitive : C3	vismodegib Sensitive: C3 – Early Trials vismodegib Sensitive : C3
PTCH1 mutation	Non Small Cell Lung Cancer	PTCH1 mutation	Non Small Cell Lung Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
PTCH1 mutation	Medulloblastoma	PTCH1 mutation	Medulloblastoma	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D	sonidegib Sensitive: D – Preclinical sonidegib Sensitive : D
PTCH1 mutation	Medulloblastoma	PTCH1 mutation	Medulloblastoma	SMO protein inhibitor Sensitive: D – Preclinical SMO protein inhibitor Sensitive : D	SMO protein inhibitor Sensitive: D – Preclinical SMO protein inhibitor Sensitive : D
PTCH1 mutation	Colorectal Cancer	PTCH1 mutation	Colorectal Cancer	Sensitive: D – Preclinical Sensitive : D	Sensitive: D – Preclinical Sensitive : D