^
Association details:
| Biomarker: | PTCH1 mutation |
|---|---|
| Cancer: | Medulloblastoma |
| Drug: | Erivedge (vismodegib) (Hedgehog cell-signalling pathway inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032
Excerpt:
...PFS for adults with SHH-MB was longer than that of adults with non-SHH–MB (P = .0279...Vismodegib exhibits activity against adult recurrent SHH-MB but not against recurrent non-SHH–MB…
DOI:
10.1200/JCO.2014.60.1591
Trial ID:
