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Association details:
| Biomarker: | PTCH1 mutation |
|---|---|
| Cancer: | Colorectal Cancer |
| Regimen: | FOLFOX (5-fluorouracil + leucovorin calcium + oxaliplatin) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Role of PTCH1 C-terminal domain mutations in colorectal cancer
Published date:
05/28/2021
Excerpt:
Homozygous PTCH1 CTD indels between S1203 and R1308 were generated in SW620 cells by CRISPR/Cas9...mutant clones showed enhanced sensitivity to FOLFOX , as determined by viability and PARP cleavage...These findings reveal the oncogenic role of mutations in the PTCH1 CTD present in a subset of CRC cases...
