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BIOMARKER:
PTCH1 mutation
i
Other names:
PTC1, Patched Homolog 1, Protein Patched Homolog 1
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Entrez ID:
5727
Related biomarkers:
Mutation
CNA
Fusion
Others
‹
›
Associations
(9)
News
Trials
Phase
Status
Apply
Phase
Status
Apply
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors (NCT03434262)
Phase 1
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
Completed
Phase 1
St. Jude Children's Research Hospital
Completed
Last update posted :
05/31/2024
Initiation :
03/05/2018
Primary completion :
09/30/2022
Completion :
05/24/2024
PTCH1
|
PTCH1 mutation
|
Mekinist (trametinib) • gemcitabine • Kisqali (ribociclib) • Odomzo (sonidegib) • Neupogen (filgrastim)
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas (A071401) (NCT02523014)
Phase 2
Alliance for Clinical Trials in Oncology
Alliance for Clinical Trials in Oncology
Recruiting
Phase 2
Alliance for Clinical Trials in Oncology
Recruiting
Last update posted :
05/23/2024
Initiation :
08/01/2015
Primary completion :
10/01/2024
Completion :
10/01/2024
PIK3CA • PTEN • CDKN2A • AKT1 • CCND1 • CCNE1 • PTCH1 • CDK4 • NF2 • SMO • CDK6 • CCND2 • CCND3
|
PIK3CA mutation • PTEN mutation • CDKN2A mutation • PTCH1 mutation • NF2 mutation • AKT1 mutation • SMO mutation • PIK3CA mutation + PTEN mutation • CDK4 mutation
|
Verzenio (abemaciclib) • Truqap (capivasertib) • Erivedge (vismodegib) • GSK2256098
Vitamin D as a Nutritional Neoadjuvant During Photodynamic Therapy of Basal Cell Carcinoma (NCT03467789)
Phase 1
Case Comprehensive Cancer Center
Case Comprehensive Cancer Center
Active, not recruiting
Phase 1
Case Comprehensive Cancer Center
Active, not recruiting
Last update posted :
05/02/2024
Initiation :
10/01/2018
Primary completion :
09/01/2024
Completion :
09/01/2024
PTCH1
|
PTCH1 mutation
Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome (NCT06050122)
Phase 3
Sol-Gel Technologies, Ltd.
Sol-Gel Technologies, Ltd.
Recruiting
Phase 3
Sol-Gel Technologies, Ltd.
Recruiting
Last update posted :
04/19/2024
Initiation :
03/17/2024
Primary completion :
12/01/2025
Completion :
12/01/2025
PTCH1
|
PTCH1 mutation
|
patidegib topical (IPI-926 topical)
A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations (NCT05199584)
Phase 2
Endeavor Biomedicines, Inc.
Endeavor Biomedicines, Inc.
Active, not recruiting
Phase 2
Endeavor Biomedicines, Inc.
Active, not recruiting
Last update posted :
12/18/2023
Initiation :
05/24/2022
Primary completion :
05/01/2024
Completion :
05/01/2024
PTCH1
|
PTCH1 mutation
|
taladegib (ENV 101)
Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects With Basal Cell Nevus Syndrome (Gorlin Syndrome) (NCT03703310)
Phase 3
PellePharm, Inc.
PellePharm, Inc.
Completed
Phase 3
PellePharm, Inc.
Completed
Last update posted :
03/08/2021
Initiation :
02/19/2019
Primary completion :
12/28/2020
Completion :
12/28/2020
PTCH1
|
PTCH1 mutation
|
patidegib topical (IPI-926 topical)
Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Face (NCT00489086)
Phase 2
UCSF Benioff Children's Hospital Oakland
UCSF Benioff Children's Hospital Oakland
Completed
Phase 2
UCSF Benioff Children's Hospital Oakland
Completed
Last update posted :
10/29/2020
Initiation :
07/01/2004
Primary completion :
06/01/2012
Completion :
06/01/2012
PTCH1
|
PTCH1 mutation
Blue vs Red Light During Levulan Based Photodynamic Therapy in Patients With Basal Cell Nevus Syndrome (NCT02157623)
Phase N/A
Edward Maytin, MD, PhD
Edward Maytin, MD, PhD
Completed
Phase N/A
Edward Maytin, MD, PhD
Completed
Last update posted :
07/30/2020
Initiation :
02/01/2016
Primary completion :
09/01/2016
Completion :
12/01/2016
PTCH1
|
PTCH1 mutation
Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell Carcinomas in Gorlin Syndrome Patients (NCT02762084)
Phase 2
PellePharm, Inc.
PellePharm, Inc.
Completed
Phase 2
PellePharm, Inc.
Completed
Last update posted :
07/23/2020
Initiation :
06/06/2016
Primary completion :
04/24/2017
Completion :
04/24/2017
PTCH1 • GLI1
|
PTCH1 mutation
|
patidegib topical (IPI-926 topical)
Photodynamic Therapy Using Blue Light or Red Light in Treating Basal Cell Carcinoma in Patients With Basal Cell Nevus Syndrome (NCT02258243)
Phase 2
Case Comprehensive Cancer Center
Case Comprehensive Cancer Center
Active, not recruiting
Phase 2
Case Comprehensive Cancer Center
Active, not recruiting
Last update posted :
11/07/2016
Initiation :
12/01/2015
Primary completion :
10/01/2016
Completion :
12/01/2017
PTCH1
|
PTCH1 mutation
Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Chest and Back (NCT00783965)
Phase 2
UCSF Benioff Children's Hospital Oakland
UCSF Benioff Children's Hospital Oakland
Completed
Phase 2
UCSF Benioff Children's Hospital Oakland
Completed
Last update posted :
02/11/2016
Initiation :
07/01/2004
Primary completion :
06/01/2012
Completion :
01/01/2014
PTCH1
|
PTCH1 mutation
A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients (NCT00961896)
Phase 2
Novartis Pharmaceuticals
Novartis Pharmaceuticals
Completed
Phase 2
Novartis Pharmaceuticals
Completed
Last update posted :
11/03/2015
Initiation :
07/01/2009
Primary completion :
08/01/2010
PTCH1
|
PTCH1 mutation
|
Odomzo (sonidegib)
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