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GENE:
PDGFRB (Platelet Derived Growth Factor Receptor Beta)
i
Other names:
PDGFRB, Platelet Derived Growth Factor Receptor Beta, Platelet-Derived Growth Factor Receptor, Beta Polypeptide, Beta-Type Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Receptor Beta, Platelet-Derived Growth Factor Receptor 1, CD140 Antigen-Like Family Member B, PDGF-R-Beta, PDGFR-Beta, PDGFR-1, PDGFR1,Beta Platelet-Derived Growth Factor Receptor, Activated Tyrosine Kinase PDGFRB, CD140b Antigen, NDEL1-PDGFRB , CD140B, IBGC4, JTK12, PENTT, IMF1 , KOGS
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Entrez ID:
5159
Related tests:
‹
FoundationOne® Heme CDx (10)
AVENIO Tumor Tissue Expanded Kit
Altera
Archer® FusionPlex® Myeloid Kit
Archer® FusionPlex® Oncology Research Kit
FusionPlex® Dx
FusionPlex® Pan Solid Tumor v2 panel
FusionPlex™ Pan-Heme panel
OncoGuide™ NCC Oncopanel System
PDGFRB FISH Assay
TruSight Tumor 170 Assay
FoundationOne® Heme CDx (10)
AVENIO Tumor Tissue Expanded Kit
Altera
Archer® FusionPlex® Myeloid Kit
Archer® FusionPlex® Oncology Research Kit
FusionPlex® Dx
FusionPlex® Pan Solid Tumor v2 panel
FusionPlex™ Pan-Heme panel
OncoGuide™ NCC Oncopanel System
PDGFRB FISH Assay
TruSight Tumor 170 Assay
›
Associations
(28)
News
Trials
VERI cancer hierarchy
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PDGFRB fusion
Childhood B Acute Lymphoblastic Leukemia
PDGFRB fusion
Childhood B Acute Lymphoblastic Leukemia
dasatinib
Sensitive: C3 – Early Trials
dasatinib
Sensitive
:
C3
dasatinib
Sensitive: C3 – Early Trials
dasatinib
Sensitive
:
C3
PDGFRB overexpression
Colorectal Cancer
PDGFRB overexpression
Colorectal Cancer
ARO-002
Sensitive: C3 – Early Trials
ARO-002
Sensitive
:
C3
ARO-002
Sensitive: C3 – Early Trials
ARO-002
Sensitive
:
C3
PDGFRB mutation
Non Small Cell Lung Cancer
PDGFRB mutation
Non Small Cell Lung Cancer
nintedanib
Sensitive: C3 – Early Trials
nintedanib
Sensitive
:
C3
nintedanib
Sensitive: C3 – Early Trials
nintedanib
Sensitive
:
C3
PDGFRB overexpression
Osteosarcoma
PDGFRB overexpression
Osteosarcoma
anlotinib
Sensitive: C3 – Early Trials
anlotinib
Sensitive
:
C3
anlotinib
Sensitive: C3 – Early Trials
anlotinib
Sensitive
:
C3
KDR overexpression + PDGFRB overexpression
Osteosarcoma
KDR overexpression + PDGFRB overexpression
Osteosarcoma
anlotinib
Sensitive: C3 – Early Trials
anlotinib
Sensitive
:
C3
anlotinib
Sensitive: C3 – Early Trials
anlotinib
Sensitive
:
C3
ALK expression + PDGFRB expression
Lymphoma
ALK expression + PDGFRB expression
Lymphoma
imatinib
Sensitive: C3 – Early Trials
imatinib
Sensitive
:
C3
imatinib
Sensitive: C3 – Early Trials
imatinib
Sensitive
:
C3
PDGFRB underexpression
Sarcoma
PDGFRB underexpression
Sarcoma
pazopanib
Resistant: C4 – Case Studies
pazopanib
Resistant
:
C4
pazopanib
Resistant: C4 – Case Studies
pazopanib
Resistant
:
C4
PDGFRB overexpression
Sarcoma
PDGFRB overexpression
Sarcoma
pazopanib
Sensitive: C4 – Case Studies
pazopanib
Sensitive
:
C4
pazopanib
Sensitive: C4 – Case Studies
pazopanib
Sensitive
:
C4
EBF1-PDGFRB fusion
B Acute Lymphoblastic Leukemia
EBF1-PDGFRB fusion
B Acute Lymphoblastic Leukemia
imatinib
Sensitive: C4 – Case Studies
imatinib
Sensitive
:
C4
imatinib
Sensitive: C4 – Case Studies
imatinib
Sensitive
:
C4
PDGFRB overexpression
Thyroid Gland Papillary Carcinoma
PDGFRB overexpression
Thyroid Gland Papillary Carcinoma
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
larotrectinib
Sensitive: C4 – Case Studies
larotrectinib
Sensitive
:
C4
ATF7IP-PDGFRB fusion
Acute Lymphocytic Leukemia
ATF7IP-PDGFRB fusion
Acute Lymphocytic Leukemia
dasatinib
Sensitive: C4 – Case Studies
dasatinib
Sensitive
:
C4
dasatinib
Sensitive: C4 – Case Studies
dasatinib
Sensitive
:
C4
PCM1-PDGFRB fusion
Myelodysplastic Syndrome
PCM1-PDGFRB fusion
Myelodysplastic Syndrome
imatinib
Sensitive: C4 – Case Studies
imatinib
Sensitive
:
C4
imatinib
Sensitive: C4 – Case Studies
imatinib
Sensitive
:
C4
CCDC88C-PDGFRB fusion
Lymphoma
CCDC88C-PDGFRB fusion
Lymphoma
imatinib
Sensitive: C4 – Case Studies
imatinib
Sensitive
:
C4
imatinib
Sensitive: C4 – Case Studies
imatinib
Sensitive
:
C4
ATF7IP-PDGFRB fusion
B Acute Lymphoblastic Leukemia
ATF7IP-PDGFRB fusion
B Acute Lymphoblastic Leukemia
Tyrosine kinase inhibitor
Sensitive: C4 – Case Studies
Tyrosine kinase inhibitor
Sensitive
:
C4
Tyrosine kinase inhibitor
Sensitive: C4 – Case Studies
Tyrosine kinase inhibitor
Sensitive
:
C4
ATF7IP-PDGFRB translocation
B Acute Lymphoblastic Leukemia
ATF7IP-PDGFRB translocation
B Acute Lymphoblastic Leukemia
dasatinib
Sensitive: C4 – Case Studies
dasatinib
Sensitive
:
C4
dasatinib
Sensitive: C4 – Case Studies
dasatinib
Sensitive
:
C4
PDGFRB overexpression
Hepatocellular Cancer
PDGFRB overexpression
Hepatocellular Cancer
Tyrosine kinase inhibitor
Sensitive: D – Preclinical
Tyrosine kinase inhibitor
Sensitive
:
D
Tyrosine kinase inhibitor
Sensitive: D – Preclinical
Tyrosine kinase inhibitor
Sensitive
:
D
PDGFRB overexpression
Melanoma
PDGFRB overexpression
Melanoma
vemurafenib
Resistant: D – Preclinical
vemurafenib
Resistant
:
D
vemurafenib
Resistant: D – Preclinical
vemurafenib
Resistant
:
D
EBF1-PDGFRB fusion
Childhood B Acute Lymphoblastic Leukemia
EBF1-PDGFRB fusion
Childhood B Acute Lymphoblastic Leukemia
dasatinib
Sensitive: D – Preclinical
dasatinib
Sensitive
:
D
dasatinib
Sensitive: D – Preclinical
dasatinib
Sensitive
:
D
ETV6-PDGFRB fusion
Acute Lymphocytic Leukemia
ETV6-PDGFRB fusion
Acute Lymphocytic Leukemia
YD312
Sensitive: D – Preclinical
YD312
Sensitive
:
D
YD312
Sensitive: D – Preclinical
YD312
Sensitive
:
D
AGGF1-PDGFRB fusion
Acute Lymphocytic Leukemia
AGGF1-PDGFRB fusion
Acute Lymphocytic Leukemia
imatinib
Resistant: D – Preclinical
imatinib
Resistant
:
D
imatinib
Resistant: D – Preclinical
imatinib
Resistant
:
D
AGGF1-PDGFRB fusion
Acute Lymphocytic Leukemia
AGGF1-PDGFRB fusion
Acute Lymphocytic Leukemia
dasatinib
Resistant: D – Preclinical
dasatinib
Resistant
:
D
dasatinib
Resistant: D – Preclinical
dasatinib
Resistant
:
D
AGGF1-PDGFRB fusion
Acute Lymphocytic Leukemia
AGGF1-PDGFRB fusion
Acute Lymphocytic Leukemia
nilotinib
Resistant: D – Preclinical
nilotinib
Resistant
:
D
nilotinib
Resistant: D – Preclinical
nilotinib
Resistant
:
D
PDGFRB C843G
Acute Lymphocytic Leukemia
PDGFRB C843G
Acute Lymphocytic Leukemia
imatinib
Resistant: D – Preclinical
imatinib
Resistant
:
D
imatinib
Resistant: D – Preclinical
imatinib
Resistant
:
D
PDGFRB C843G
Acute Lymphocytic Leukemia
PDGFRB C843G
Acute Lymphocytic Leukemia
dasatinib
Resistant: D – Preclinical
dasatinib
Resistant
:
D
dasatinib
Resistant: D – Preclinical
dasatinib
Resistant
:
D
PDGFRB C843G
Acute Lymphocytic Leukemia
PDGFRB C843G
Acute Lymphocytic Leukemia
ponatinib
Resistant: D – Preclinical
ponatinib
Resistant
:
D
ponatinib
Resistant: D – Preclinical
ponatinib
Resistant
:
D
PDGFRB C843G
Acute Lymphocytic Leukemia
PDGFRB C843G
Acute Lymphocytic Leukemia
nilotinib
Resistant: D – Preclinical
nilotinib
Resistant
:
D
nilotinib
Resistant: D – Preclinical
nilotinib
Resistant
:
D
PDGFRB C843G
Acute Lymphocytic Leukemia
PDGFRB C843G
Acute Lymphocytic Leukemia
CHZ868
Sensitive: D – Preclinical
CHZ868
Sensitive
:
D
CHZ868
Sensitive: D – Preclinical
CHZ868
Sensitive
:
D
ATF7IP-PDGFRB fusion
Acute Lymphocytic Leukemia
ATF7IP-PDGFRB fusion
Acute Lymphocytic Leukemia
imatinib
Sensitive: D – Preclinical
imatinib
Sensitive
:
D
imatinib
Sensitive: D – Preclinical
imatinib
Sensitive
:
D
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