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Association details:
| Biomarker: | HER-2 amplification + PD-L1 expression |
|---|---|
| Cancer: | Gastroesophageal Junction Adenocarcinoma |
| Drug: | Keytruda (pembrolizumab) (PD1 inhibitor) + Margenza (margetuximab-cmkb) (HER2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
BIOMARKER-GUIDED ENRICHMENT OF THE ANTITUMOR ACTIVITY OF MARGETUXIMAB (M) PLUS PEMBROLIZUMAB (P) IN PATIENTS WITH ADVANCED HER2+ GASTRIC ADENOCARCINOMA (GEA)
Published date:
10/21/2018
Excerpt:
The presence of ERBB2 amplification by ctDNA and tumor PD-L1 expression by IHC were both associated with increased probability of OR: 33.3% v. 10.5% (p = 0.0948) and 43.8% v. 16.7% (p = 0.0769), respectively. ORR was 5 of 8 (62.5%) in ERBB2 amplified/PD-L1+ pts
DOI:
10.1093/annonc/mdy282
Trial ID:
