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BIOMARKER:

KRAS G12C + PD-L1 underexpression

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Entrez ID:

Related biomarkers:

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PD-L1 elevation (15)

TMB-H + PD-L1 expression (15)

EGFR mutation + PD-L1 overexpression (8)

TMB-H + PD-L1 overexpression (7)

STK11 deletion + KRAS mutation (6)

EGFR exon 19 deletion + PD-L1 overexpression (5)

EGFR mutation + PD-L1 expression (5)

KRAS G12C + PD-L1 overexpression (4)

KRAS mutation + PD-L1 expression (4)

MSI-H/dMMR + PD-L1 expression (4)

PD-L1 expression + EGFR mutation (4)

CD74-ROS1 F2004L + PD-L1 expression (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

PD-L1 expression + TMB-H (3)

PD-L1 overexpression + KRAS mutation (3)

CPS1 overexpression + KRAS mutation + STK11 mutation (3)

HER-2 amplification + KRAS G12D (3)

KEAP1 deletion + KRAS mutation (3)

ALK rearrangement + PD-L1 overepxression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

EGFR L858R + PD-L1 overexpression (2)

EGFR exon 19 deletion + PD-L1 expression (2)

HER-2 amplification + PD-L1 expression (2)

KRAS mutation + PD-L1 negative (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

PD-1-L + PD-L1 elevation (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 expression + TMB-H + FANCA deletion (2)

PD-L1 overexpression + BRAF V600E (2)

PD-L1 overexpression + EGFR mutation (2)

PD-L1 overexpression + FGFR3 amplification (2)

PD-L1 overexpression + MET exon 14 mutation (2)

RAD51B promoter methylation + PD-L1 expression (2)

TMB-H + PD-L1 negative (2)

TMB-H + PD-L1 underexpression (2)

TMB-L + PD-L1 expression (2)

EGFR exon 19 deletion + KRAS mutation (2)

MSI-L/dMMR + KRAS G12V (2)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BAP1 R300Gfs*6 + PD-L1 expression (1)

BAP1 deletion + TMB-L + PD-L1 expression (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF mutation + PD-L1 overexpression (1)

BRCA1 mutation + PD-L1 expression (1)

CDKN2A mutation + PD-L1 overexpression (1)

Chr del(9p) + PD-L1 overexpression (1)

DDR + PD-L1 expression (1)

EGFR G719A + EGFR S768I + PD-L1 overexpression (1)

EGFR G719A + PD-L1 overexpression (1)

EGFR L747P + PD-L1 overexpression (1)

EGFR L858R + PD-L1 expression (1)

EGFR L858R + PD-L1 underexpression (1)

EGFR P719A + PD-L1 overexpression (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + EGFR T790M + PD-L1 expression (1)

EGFR exon 19 deletion + PD-L1 underexpression (1)

EGFR exon 20 insertion + PD-L1 overexpression (1)

EGFR fusion + PD-L1 overexpression (1)

EGFR mutation + PD-L1 elevation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + PD-L1 negative (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

FGFR mutation + PD-L1 expression (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HLA-A*02 + PD-L1 expression (1)

HLA-A*02:01 + PD-L1 expression (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

KEAP1 mutation + TMB-H + PD-L1 overexpression (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + PD-L1 expression (1)

KRAS G12C + PD-L1 expression (1)

KRAS G12C + PD-L1 underexpression + STK11 mutation (1)

KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)

KRAS mutation + PD-L1 underexpression (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDHA-L + PD-L1 expression (1)

LDHB-L + PD-L1 expression (1)

MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)

MGAM mutation + PD-L1 overexpression (1)

PAPPA2 mutation + PD-L1 expression (1)

PD-L1 amplification + CD3D overexpression (1)

PD-L1 amplification + HLA-DRA overexpression (1)

PD-L1 amplification + LAG3 overexpression (1)

PD-L1 amplification + PD-L2 amplification + TMB-H (1)

PD-L1 deletion + STK11 mutation (1)

PD-L1 elevation + CXCL10 elevation + TNFA elevation (1)

PD-L1 expression + BRAF negative (1)

PD-L1 expression + JAK2 mutation (1)

PD-L1 expression + KMT2D mutation (1)

PD-L1 expression + MSI-H/dMMR (1)

PD-L1 expression + MSI-L/dMMR (1)

PD-L1 expression + PIK3CA mutation (1)

PD-L1 expression + STK11 mutation (1)

PD-L1 expression + STK11 mutation + JAK2 mutation (1)

PD-L1 expression + T-cell gene signature (1)

PD-L1 negative + KRAS G12C (1)

PD-L1 negative + TMB-L (1)

PD-L1 negative + TMB-L + STING overexpression (1)

PD-L1 overexpression + HER-2 exon 20 insertion (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-CCDC6 fusion (1)

PD-L1 overexpression + RET-KIF5B fusion (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

PD-L1 overexpression + TMB-H (1)

PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)

PD-L1 overexpression + TMB-L (1)

PD-L1 underexpression + EGFR mutation (1)

PIK3CA R88Q + PD-L1 expression (1)

POLE mutation + PD-L1 negative + TMB-H (1)

RB1 mutation + PD-L1 expression (1)

RET amplification + TMB-H + PD-L1 expression (1)

ROS1 rearrangement + PD-L1 overexpression (1)

RYR1 mutation + PD-L1 overexpression (1)

SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + TMB-H + PD-L1 overexpression (1)

TERT positive + PD-L1 expression (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

TMB-H + RB1 mutation + PD-L1 underexpression (1)

TMB-L + PD-L1 underexpression (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)

AXL overexpression + KRAS G12C (1)

CDH2 overexpression + KRAS wild-type (1)

Chr t(11;14) + KRAS mutation (1)

EGFR C797S + KRAS amplification + RB1 deletion (1)

EGFR L858R + KRAS amplification + RB1 deletion (1)

EGFR T790M + KRAS amplification + RB1 deletion (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR expression + KRAS G12C (1)

EGFR overexpression + KRAS 13D (1)

EGFR overexpression + KRAS mutation (1)

FGFR1 overexpression + KRAS G12C (1)

GNA13 deletion + KRAS mutation (1)

GOPC-ROS1 fusion + KRAS Q61H (1)

HER-2 amplification + KRAS exon 2 wild-type (1)

HER-2 amplification + KRAS wild-type (1)

HER-2 overexpression + KRAS wild-type (1)

IGF1R overexpression + KRAS mutation (1)

IR overexpression + KRAS mutation (1)

IRS2 amplification + KRAS mutation (1)

KEAP1 mutation + KRAS wild-type (1)

KRAS A146 + TMB-H (1)

KRAS G12D + Chr del(9)(p21) (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

KRAS G12D + TP53 deletion (1)

KRAS amplification + BRAF wild-type (1)

KRAS amplification + RAS wild-type (1)

KRAS mutation + BCL2A1 overexpression (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + EGFR amplification (1)

KRAS mutation + ER expression (1)

KRAS mutation + HER-2 positive (1)

KRAS mutation + HR positive (1)

KRAS mutation + PIK3CA wild-type (1)

KRAS mutation + PTPN11 overexpression (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + YKL-40 overexpression (1)

KRAS wild-type + BRAF V600E (1)

KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)

KRAS mutation + STK11 mutation + AXL expression (1)

MLL-AFF1 fusion + KRAS mutation (1)

MSI-H/dMMR + KRAS G12D (1)

MSI-H/dMMR + KRAS Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

MTAP deletion + KRAS G12C (1)

POMK-NRG1 fusion + KRAS mutation (1)

POMK‐NRG1 fusion + KRAS G12D (1)

PTEN deletion + KRAS G12C (1)

RET positive + KRAS G12V (1)

ROS1 fusion + KRAS G12C (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

STRN-ALK fusion + KRAS G13D (1)

TP53 S12F + KRAS G12D + TMB-L (1)

ARID1A mutation + PD-L1 expression (0)

DDX3X mutation + PD-L1 overexpression (0)

LDHA-H + PD-L1 negative (0)

LDHB-H + PD-L1 negative (0)

NOTCH4 mutation + PD-L1 expression + TMB-H (0)

PD-L1 overexpression + BRAF mutation (0)

PD-L1 underexpression + ALK wild-type (0)

PD-L1 underexpression + EGFR wild-type (0)

STAT3 mutation + PD-L1 overexpression (0)

HER-2 amplification + KRAS G12C (0)

PRMT5 overexpression + KRAS mutation (0)

PD-L1 elevation (15)

TMB-H + PD-L1 expression (15)

EGFR mutation + PD-L1 overexpression (8)

TMB-H + PD-L1 overexpression (7)

STK11 deletion + KRAS mutation (6)

EGFR exon 19 deletion + PD-L1 overexpression (5)

EGFR mutation + PD-L1 expression (5)

KRAS G12C + PD-L1 overexpression (4)

KRAS mutation + PD-L1 expression (4)

MSI-H/dMMR + PD-L1 expression (4)

PD-L1 expression + EGFR mutation (4)

CD74-ROS1 F2004L + PD-L1 expression (3)

EGFR wild-type + ALK wild-type + PD-L1 expression (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

PD-L1 expression + TMB-H (3)

PD-L1 overexpression + KRAS mutation (3)

CPS1 overexpression + KRAS mutation + STK11 mutation (3)

HER-2 amplification + KRAS G12D (3)

KEAP1 deletion + KRAS mutation (3)

ALK rearrangement + PD-L1 overepxression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

EGFR L858R + PD-L1 overexpression (2)

EGFR exon 19 deletion + PD-L1 expression (2)

HER-2 amplification + PD-L1 expression (2)

KRAS mutation + PD-L1 negative (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

PD-1-L + PD-L1 elevation (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 expression + TMB-H + FANCA deletion (2)

PD-L1 overexpression + BRAF V600E (2)

PD-L1 overexpression + EGFR mutation (2)

PD-L1 overexpression + FGFR3 amplification (2)

PD-L1 overexpression + MET exon 14 mutation (2)

RAD51B promoter methylation + PD-L1 expression (2)

TMB-H + PD-L1 negative (2)

TMB-H + PD-L1 underexpression (2)

TMB-L + PD-L1 expression (2)

EGFR exon 19 deletion + KRAS mutation (2)

MSI-L/dMMR + KRAS G12V (2)

ALK wild-type + NT5E overexpression + PD-L1 expression (1)

ALK-EML4_V3a + PD-L1 overexpression (1)

ALK-EML4_V3b + PD-L1 overexpression (1)

BAP1 R300Gfs*6 + PD-L1 expression (1)

BAP1 deletion + TMB-L + PD-L1 expression (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF mutation + PD-L1 overexpression (1)

BRCA1 mutation + PD-L1 expression (1)

CDKN2A mutation + PD-L1 overexpression (1)

Chr del(9p) + PD-L1 overexpression (1)

DDR + PD-L1 expression (1)

EGFR G719A + EGFR S768I + PD-L1 overexpression (1)

EGFR G719A + PD-L1 overexpression (1)

EGFR L747P + PD-L1 overexpression (1)

EGFR L858R + PD-L1 expression (1)

EGFR L858R + PD-L1 underexpression (1)

EGFR P719A + PD-L1 overexpression (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + EGFR T790M + PD-L1 expression (1)

EGFR exon 19 deletion + PD-L1 underexpression (1)

EGFR exon 20 insertion + PD-L1 overexpression (1)

EGFR fusion + PD-L1 overexpression (1)

EGFR mutation + PD-L1 elevation (1)

EGFR mutation + PD-L1 expression + TP53 mutation (1)

EGFR mutation + PD-L1 negative (1)

EGFR negative + ALK negative + PD-L1 expression (1)

EGFR wild-type + ALK wild-type + NT5E overexpression + PD-L1 expression (1)

FGFR mutation + PD-L1 expression (1)

HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)

HLA-A*02 + PD-L1 expression (1)

HLA-A*02:01 + PD-L1 expression (1)

HRAS Q61R + TP53 P278S + PD-L1 overexpression (1)

KEAP1 mutation + TMB-H + PD-L1 overexpression (1)

KMT2C mutation + BCOR mutation + KDM5C mutation + PD-L1 expression (1)

KRAS G12C + PD-L1 expression (1)

KRAS G12C + PD-L1 underexpression + STK11 mutation (1)

KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)

KRAS mutation + PD-L1 underexpression (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

LDHA-L + PD-L1 expression (1)

LDHB-L + PD-L1 expression (1)

MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)

MGAM mutation + PD-L1 overexpression (1)

PAPPA2 mutation + PD-L1 expression (1)

PD-L1 amplification + CD3D overexpression (1)

PD-L1 amplification + HLA-DRA overexpression (1)

PD-L1 amplification + LAG3 overexpression (1)

PD-L1 amplification + PD-L2 amplification + TMB-H (1)

PD-L1 deletion + STK11 mutation (1)

PD-L1 elevation + CXCL10 elevation + TNFA elevation (1)

PD-L1 expression + BRAF negative (1)

PD-L1 expression + JAK2 mutation (1)

PD-L1 expression + KMT2D mutation (1)

PD-L1 expression + MSI-H/dMMR (1)

PD-L1 expression + MSI-L/dMMR (1)

PD-L1 expression + PIK3CA mutation (1)

PD-L1 expression + STK11 mutation (1)

PD-L1 expression + STK11 mutation + JAK2 mutation (1)

PD-L1 expression + T-cell gene signature (1)

PD-L1 negative + KRAS G12C (1)

PD-L1 negative + TMB-L (1)

PD-L1 negative + TMB-L + STING overexpression (1)

PD-L1 overexpression + HER-2 exon 20 insertion (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

PD-L1 overexpression + RET-CCDC6 fusion (1)

PD-L1 overexpression + RET-KIF5B fusion (1)

PD-L1 overexpression + RET-KIF5B fusion + TP53 mutation + AR mutation + RET rearrangement (1)

PD-L1 overexpression + TMB-H (1)

PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)

PD-L1 overexpression + TMB-L (1)

PD-L1 underexpression + EGFR mutation (1)

PIK3CA R88Q + PD-L1 expression (1)

POLE mutation + PD-L1 negative + TMB-H (1)

RB1 mutation + PD-L1 expression (1)

RET amplification + TMB-H + PD-L1 expression (1)

ROS1 rearrangement + PD-L1 overexpression (1)

RYR1 mutation + PD-L1 overexpression (1)

SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

STK11 mutation + TMB-H + PD-L1 overexpression (1)

TERT positive + PD-L1 expression (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

TMB-H + RB1 mutation + PD-L1 underexpression (1)

TMB-L + PD-L1 underexpression (1)

TP53 mutation + MET amplification + PD-L1 overexpression (1)

TP53 mutation + PD-L1 expression (1)

TP53 mutation + PD-L1 negative (1)

TP53 mutation + TMB-H + PD-L1 overexpression (1)

TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)

AXL overexpression + KRAS G12C (1)

CDH2 overexpression + KRAS wild-type (1)

Chr t(11;14) + KRAS mutation (1)

EGFR C797S + KRAS amplification + RB1 deletion (1)

EGFR L858R + KRAS amplification + RB1 deletion (1)

EGFR T790M + KRAS amplification + RB1 deletion (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR expression + KRAS G12C (1)

EGFR overexpression + KRAS 13D (1)

EGFR overexpression + KRAS mutation (1)

FGFR1 overexpression + KRAS G12C (1)

GNA13 deletion + KRAS mutation (1)

GOPC-ROS1 fusion + KRAS Q61H (1)

HER-2 amplification + KRAS exon 2 wild-type (1)

HER-2 amplification + KRAS wild-type (1)

HER-2 overexpression + KRAS wild-type (1)

IGF1R overexpression + KRAS mutation (1)

IR overexpression + KRAS mutation (1)

IRS2 amplification + KRAS mutation (1)

KEAP1 mutation + KRAS wild-type (1)

KRAS A146 + TMB-H (1)

KRAS G12D + Chr del(9)(p21) (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

KRAS G12D + TP53 deletion (1)

KRAS amplification + BRAF wild-type (1)

KRAS amplification + RAS wild-type (1)

KRAS mutation + BCL2A1 overexpression (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + EGFR amplification (1)

KRAS mutation + ER expression (1)

KRAS mutation + HER-2 positive (1)

KRAS mutation + HR positive (1)

KRAS mutation + PIK3CA wild-type (1)

KRAS mutation + PTPN11 overexpression (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + YKL-40 overexpression (1)

KRAS wild-type + BRAF V600E (1)

KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)

KRAS mutation + STK11 mutation + AXL expression (1)

MLL-AFF1 fusion + KRAS mutation (1)

MSI-H/dMMR + KRAS G12D (1)

MSI-H/dMMR + KRAS Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

MTAP deletion + KRAS G12C (1)

POMK-NRG1 fusion + KRAS mutation (1)

POMK‐NRG1 fusion + KRAS G12D (1)

PTEN deletion + KRAS G12C (1)

RET positive + KRAS G12V (1)

ROS1 fusion + KRAS G12C (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

STRN-ALK fusion + KRAS G13D (1)

TP53 S12F + KRAS G12D + TMB-L (1)

ARID1A mutation + PD-L1 expression (0)

DDX3X mutation + PD-L1 overexpression (0)

LDHA-H + PD-L1 negative (0)

LDHB-H + PD-L1 negative (0)

NOTCH4 mutation + PD-L1 expression + TMB-H (0)

PD-L1 overexpression + BRAF mutation (0)

PD-L1 underexpression + ALK wild-type (0)

PD-L1 underexpression + EGFR wild-type (0)

STAT3 mutation + PD-L1 overexpression (0)

HER-2 amplification + KRAS G12C (0)

PRMT5 overexpression + KRAS mutation (0)

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KRAS G12C + PD-L1 underexpression	Non Small Cell Lung Cancer	KRAS G12C + PD-L1 underexpression	Non Small Cell Lung Cancer	sotorasib Sensitive: C3 – Early Trials sotorasib Sensitive : C3	sotorasib Sensitive: C3 – Early Trials sotorasib Sensitive : C3
KRAS G12C + PD-L1 underexpression	Non Small Cell Lung Cancer	KRAS G12C + PD-L1 underexpression	Non Small Cell Lung Cancer	pembrolizumab Sensitive: C3 – Early Trials pembrolizumab Sensitive : C3	pembrolizumab Sensitive: C3 – Early Trials pembrolizumab Sensitive : C3