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BIOMARKER:
IDH1 R132H
i
Other names:
HEL-216, HEL-S-26, Epididymis Luminal Protein 216, Isocitrate Dehydrogenase 1 (NADP+), Epididymis Secretory Protein Li 26, IDH1, Isocitrate Dehydrogenase (NADP(+)) 1, Isocitrate Dehydrogenase 1 (NADP+), Soluble
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Entrez ID:
3417
Related biomarkers:
Expression
Mutation
Others
‹
IDH1 mutation + Chr del(1p) + Chr del(19q) (10)
IDH1 mutation + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH1 mutation + NTRK1 fusion (2)
IDH1 mutation + NTRK2 fusion (2)
IDH1 mutation + NTRK3 fusion (2)
MYC overexpression + IDH1 mutation (2)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
IDH1 mutation + FGFR2 fusion (1)
IDH1 mutation + FGFR2 rearrangement (1)
IDH1 mutation + MGMT promoter methylation (1)
IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH1 mutation + TMB-L (1)
IDH1 mutation + WT1 overexpression (1)
IDH1 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
IDH1 mutation + Chr del(1p) + Chr del(19q) (10)
IDH1 mutation + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion (2)
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion (2)
IDH1 mutation + NTRK1 fusion (2)
IDH1 mutation + NTRK2 fusion (2)
IDH1 mutation + NTRK3 fusion (2)
MYC overexpression + IDH1 mutation (2)
IDH wild-type + FGFR3 S249C + TP53 V73fs (1)
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)
IDH1 mutation + ATRX deletion + TP53 deletion (1)
IDH1 mutation + FGFR2 fusion (1)
IDH1 mutation + FGFR2 rearrangement (1)
IDH1 mutation + MGMT promoter methylation (1)
IDH1 mutation + MYC amplification + MAPRE1 overexpression (1)
IDH1 mutation + TMB-L (1)
IDH1 mutation + WT1 overexpression (1)
IDH1 mutation + Chr del(1p) + Chr del(19q) + MGMT promoter methylation (0)
›
Related tests:
Abbott RealTime IDH1 (4)
Abbott RealTime IDH1 (4)
Associations
News
Trials
VERI cancer hierarchy
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IDH1 R132H
Anaplastic Astrocytoma
IDH1 R132H
Anaplastic Astrocytoma
temozolomide
Sensitive: B - Late Trials
temozolomide
Sensitive
:
B
temozolomide
Sensitive: B - Late Trials
temozolomide
Sensitive
:
B
IDH1 R132H
Acute Myelogenous Leukemia
IDH1 R132H
Acute Myelogenous Leukemia
dasatinib
Sensitive: C3 – Early Trials
dasatinib
Sensitive
:
C3
dasatinib
Sensitive: C3 – Early Trials
dasatinib
Sensitive
:
C3
IDH1 R132H
Acute Myelogenous Leukemia
IDH1 R132H
Acute Myelogenous Leukemia
midostaurin
Sensitive: C4 – Case Studies
midostaurin
Sensitive
:
C4
midostaurin
Sensitive: C4 – Case Studies
midostaurin
Sensitive
:
C4
IDH1 R132H
Glioma
IDH1 R132H
Glioma
PD-L1 inhibitor + IDH1 inhibitor
Sensitive: D – Preclinical
PD-L1 inhibitor + IDH1 inhibitor
Sensitive
:
D
PD-L1 inhibitor + IDH1 inhibitor
Sensitive: D – Preclinical
PD-L1 inhibitor + IDH1 inhibitor
Sensitive
:
D
IDH1 R132H
Glioma
IDH1 R132H
Glioma
olaparib + AZD6738
Sensitive: D – Preclinical
olaparib + AZD6738
Sensitive
:
D
olaparib + AZD6738
Sensitive: D – Preclinical
olaparib + AZD6738
Sensitive
:
D
IDH1 R132H
Acute Myelogenous Leukemia
IDH1 R132H
Acute Myelogenous Leukemia
venetoclax + midostaurin + LY3410738
Sensitive: D – Preclinical
venetoclax + midostaurin + LY3410738
Sensitive
:
D
venetoclax + midostaurin + LY3410738
Sensitive: D – Preclinical
venetoclax + midostaurin + LY3410738
Sensitive
:
D
IDH1 R132H
Glioma
IDH1 R132H
Glioma
AGI-5198
Sensitive: D – Preclinical
AGI-5198
Sensitive
:
D
AGI-5198
Sensitive: D – Preclinical
AGI-5198
Sensitive
:
D
IDH1 R132H
Acute Myelogenous Leukemia
IDH1 R132H
Acute Myelogenous Leukemia
GSK321
Sensitive: D – Preclinical
GSK321
Sensitive
:
D
GSK321
Sensitive: D – Preclinical
GSK321
Sensitive
:
D
IDH1 R132H
Glioma
IDH1 R132H
Glioma
temozolomide + azacitidine
Sensitive: D – Preclinical
temozolomide + azacitidine
Sensitive
:
D
temozolomide + azacitidine
Sensitive: D – Preclinical
temozolomide + azacitidine
Sensitive
:
D
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